PMID- 30009939
OWN - NLM
STAT- MEDLINE
DCOM- 20181105
LR  - 20181105
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 143
DP  - 2018 Sep
TI  - Lower alpha fetoprotein and higher risk of hepatocellular carcinoma, study from 
      the type 2 diabetes mellitus patients.
PG  - 239-244
LID - S0168-8227(18)30729-0 [pii]
LID - 10.1016/j.diabres.2018.07.018 [doi]
AB  - AIMS: To explore the association of type 2 diabetes mellitus (T2DM) with 
      hepatocellular carcinoma (HCC) and alpha fetoprotein (AFP). METHODS: 750 patients 
      with T2DM (T2DM group), 800 healthy people (control group) and 501 patients newly 
      diagnosed with HCC were recruited from 2010 to 2016. The HCC patients were 
      further divided into a HCC with T2DM (HCC+DM) group and a HCC without diabetes 
      mellitus (HCC+NDM) group. RESULTS: The T2DM group had a 12.61% lower geometric 
      mean AFP level than the healthy control group (2.08 vs. 2.38 mug/L, P < 0.001). Of 
      501 HCC patients, 230 (45.91%) had T2DM. When compared to the HCC+NDM group, the 
      HCC+DM group had a higher negative rate of AFP (55.22% vs. 37.26%, P < 0.001), 
      worse liver function (P = 0.011) and a 64.87% lower geometric mean AFP level 
      (25.71 vs. 73.18 mug/L, P < 0.001). T2DM was significantly associated with the 
      risk of high-grade (grade 3 and 4) HCC (OR = 2.02, 95% CI 1.18-3.44, P = 0.010). 
      CONCLUSIONS: T2DM was associated with lower AFP level, worse liver function and 
      higher risk of high-grade HCC. We speculated that low AFP levels in diabetics 
      might delay and interfere with HCC diagnosis, leading to higher degree of 
      malignant HCC.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Yang, Shaoling
AU  - Yang S
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Liu, Lu
AU  - Liu L
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Luo, Yili
AU  - Luo Y
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Chen, Ming
AU  - Chen M
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Li, Nan
AU  - Li N
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Xu, Lu
AU  - Xu L
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Wang, Yanru
AU  - Wang Y
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Lin, Ziwei
AU  - Lin Z
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai 200072, China.
FAU - Li, Hong
AU  - Li H
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai 200072, China. Electronic address: 
      lihong_endo@tongji.edu.cn.
FAU - Qu, Shen
AU  - Qu S
AD  - Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, 
      Tongji University School of Medicine, Shanghai 200072, China.
LA  - eng
PT  - Journal Article
DEP - 20180731
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (alpha-Fetoproteins)
SB  - IM
MH  - Aged
MH  - Carcinoma, Hepatocellular/*diagnosis/pathology
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/*diagnosis/pathology
MH  - Male
MH  - Middle Aged
MH  - alpha-Fetoproteins/*metabolism
OTO - NOTNLM
OT  - Alpha-fetoprotein
OT  - Hepatocellular carcinoma
OT  - Type 2 diabetes mellitus
EDAT- 2018/07/17 06:00
MHDA- 2018/11/06 06:00
CRDT- 2018/07/17 06:00
PHST- 2018/05/05 00:00 [received]
PHST- 2018/06/15 00:00 [revised]
PHST- 2018/07/09 00:00 [accepted]
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2018/07/17 06:00 [entrez]
AID - S0168-8227(18)30729-0 [pii]
AID - 10.1016/j.diabres.2018.07.018 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2018 Sep;143:239-244. doi: 
      10.1016/j.diabres.2018.07.018. Epub 2018 Jul 31.