PMID- 30010095
OWN - NLM
STAT- MEDLINE
DCOM- 20190531
LR  - 20190531
IS  - 1878-5034 (Electronic)
IS  - 0006-355X (Linking)
VI  - 1
IP  - 0
DP  - 2018 Jul 10
TI  - Depletion-model-based numerical simulation of the kinetics of red blood cell 
      aggregation under sinusoidal pulsatile flow.
PG  - 1-14
LID - 10.3233/BIR-170147 [doi]
AB  - BACKGROUND: Previous numerical modeling studies on red blood cell (RBC) 
      aggregation have elucidated the inverse relationship between shear rate and RBC 
      aggregation under steady flow. However, information on the cyclic variation in 
      RBC aggregation under pulsatile flow remains lacking. OBJECTIVE: RBC aggregation 
      was simulated to investigate the complex interrelationships among the parameters 
      of RBC motion under pulsatile flow. METHODS: A two-dimensional particle model was 
      used to simulate RBC motion driven by hydrodynamic, aggregation, and elastic 
      forces in a sinusoidal pulsatile flow field. The kinetics of RBCs motion was 
      simulated on the basis of the depletion model. RESULTS: The simulation results 
      corresponded with previously obtained experimental results for the formation and 
      destruction of RBC aggregates with a parabolic radial distribution during a 
      pulsatile cycle. In addition, the results demonstrated that the cyclic variation 
      in the mean aggregate size of RBCs increased as velocity amplitude increased from 
      1 cm/s to 3 cm/s under a mean steady flow of 2 cm/s, as mean steady flow velocity 
      decreased from 6 cm/s to 2 cm/s under a velocity amplitude of 1.5 cm/s, and as 
      stroke rate decreased from 180 beats per minute (bpm) to 60 bpm. CONCLUSIONS: The 
      present simulation results verified previous experimental results and improved 
      the current understanding of the complex spatiotemporal changes experienced by 
      RBC aggregates during a sinusoidal pulsatile cycle.
FAU - Lee, Cheong-Ah
AU  - Lee CA
AD  - Department of Ocean System Engineering, Jeju National University, Jeju, Korea.
FAU - Kong, Qi
AU  - Kong Q
AD  - Department of Ocean System Engineering, Jeju National University, Jeju, Korea.
FAU - Paeng, Dong-Guk
AU  - Paeng DG
AD  - Department of Ocean System Engineering, Jeju National University, Jeju, Korea.
AD  - Department of Radiation Oncology, University of Virginia, Charlottesville, VA, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biorheology
JT  - Biorheology
JID - 0372526
SB  - IM
MH  - *Erythrocyte Aggregation
MH  - Kinetics
MH  - *Models, Biological
MH  - *Pulsatile Flow
OTO - NOTNLM
OT  - Poiseuille flow
OT  - Red blood cell aggregation
OT  - hemodynamics
OT  - mean aggregate size
OT  - rouleaux
OT  - sinusoidal pulsatile cycle
EDAT- 2018/07/17 06:00
MHDA- 2019/06/01 06:00
CRDT- 2018/07/17 06:00
PHST- 2018/07/17 06:00 [entrez]
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2019/06/01 06:00 [medline]
AID - BIR170147 [pii]
AID - 10.3233/BIR-170147 [doi]
PST - ppublish
SO  - Biorheology. 2018 Jul 10;1(0):1-14. doi: 10.3233/BIR-170147.