PMID- 30010844
OWN - NLM
STAT- MEDLINE
DCOM- 20190305
LR  - 20230928
IS  - 1945-7170 (Electronic)
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 159
IP  - 9
DP  - 2018 Sep 1
TI  - KNDy Cells Revisited.
PG  - 3219-3234
LID - 10.1210/en.2018-00389 [doi]
AB  - In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were 
      first identified in the mammalian hypothalamus, a plethora of new research has 
      emerged adding insights into the role of this neuronal population in reproductive 
      neuroendocrine function, including the basis for GnRH pulse generation and the 
      mechanisms underlying the steroid feedback control of GnRH secretion. In this 
      mini-review, we provide an update of evidence regarding the roles of KNDy 
      peptides and their postsynaptic receptors in producing episodic GnRH release and 
      assess the relative contribution of KNDy neurons to the "GnRH pulse generator." 
      In addition, we examine recent work investigating the role of KNDy neurons as 
      mediators of steroid hormone negative feedback and review evidence for their 
      involvement in the preovulatory GnRH/LH surge, taking into account species 
      differences that exist among rodents, ruminants, and primates. Finally, we 
      summarize emerging roles of KNDy neurons in other aspects of reproductive 
      function and in nonreproductive functions and discuss critical unresolved 
      questions in our understanding of KNDy neurobiology.
FAU - Moore, Aleisha M
AU  - Moore AM
AD  - Department of Neurobiology and Anatomical Sciences, University of Mississippi 
      Medical Center, Jackson, Mississippi.
FAU - Coolen, Lique M
AU  - Coolen LM
AD  - Department of Neurobiology and Anatomical Sciences, University of Mississippi 
      Medical Center, Jackson, Mississippi.
AD  - Department of Physics and Biophysics, University of Mississippi Medical Center, 
      Jackson, Mississippi.
FAU - Porter, Danielle T
AU  - Porter DT
AD  - Department of Neurobiology and Anatomical Sciences, University of Mississippi 
      Medical Center, Jackson, Mississippi.
FAU - Goodman, Robert L
AU  - Goodman RL
AD  - Department of Physiology, Pharmacology, and Neuroscience, West Virginia 
      University, Morgantown, West Virginia.
FAU - Lehman, Michael N
AU  - Lehman MN
AD  - Department of Neurobiology and Anatomical Sciences, University of Mississippi 
      Medical Center, Jackson, Mississippi.
LA  - eng
GR  - R01 HD039916/HD/NICHD NIH HHS/United States
GR  - R01 HD082135/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Estrogens)
RN  - 0 (Kisspeptins)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 3XMK78S47O (Testosterone)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 74913-18-1 (Dynorphins)
RN  - 86933-75-7 (Neurokinin B)
SB  - IM
MH  - Animals
MH  - Dynorphins/*metabolism
MH  - Estrogens/metabolism
MH  - Female
MH  - Gonadotropin-Releasing Hormone/*metabolism
MH  - Humans
MH  - Hypothalamus/cytology/*metabolism/physiology
MH  - Kisspeptins/*metabolism
MH  - Neurokinin B/*metabolism
MH  - Neurons/*metabolism/physiology
MH  - Progesterone/metabolism
MH  - Reproduction/physiology
MH  - Testosterone/metabolism
PMC - PMC6098225
EDAT- 2018/07/17 06:00
MHDA- 2019/03/06 06:00
PMCR- 2019/09/01
CRDT- 2018/07/17 06:00
PHST- 2018/04/27 00:00 [received]
PHST- 2018/07/05 00:00 [accepted]
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2019/03/06 06:00 [medline]
PHST- 2018/07/17 06:00 [entrez]
PHST- 2019/09/01 00:00 [pmc-release]
AID - 5051603 [pii]
AID - endo_201800389 [pii]
AID - 10.1210/en.2018-00389 [doi]
PST - ppublish
SO  - Endocrinology. 2018 Sep 1;159(9):3219-3234. doi: 10.1210/en.2018-00389.