PMID- 30011110
OWN - NLM
STAT- MEDLINE
DCOM- 20190225
LR  - 20190225
IS  - 1099-1492 (Electronic)
IS  - 0952-3480 (Linking)
VI  - 31
IP  - 9
DP  - 2018 Sep
TI  - Intragastric balloon therapy leads to normalization of brain magnetic resonance 
      spectroscopic markers of diabetes in morbidly obese patients.
PG  - e3957
LID - 10.1002/nbm.3957 [doi]
AB  - Elevated brain myo-inositol (m-Ins) concentration (a putative marker of 
      neuroinflammation) has been reported in patients suffering from type 2 diabetes 
      mellitus (T2DM). Obesity alone and T2DM have been found to be associated with a 
      lower concentration of N-acetyloaspartate and N-acetylaspartylglutamate (tNAA, a 
      marker of neuronal integrity, reflecting neuronal loss or metabolic derangement). 
      It is not clear if these changes reverse with weight loss. The intra-gastric 
      balloon (IGB) is an endoscopic bariatric therapy that leads to massive weight 
      loss and improvement of glycemic control. In this study we evaluated if tNAA/tCr 
      and m-Ins/tCr metabolite ratios are affected by weight loss, where tCr is the 
      signal of creatine containing compounds. Twenty-three morbidly obese patients, 12 
      of them with T2DM (OD) and 11 without T2DM (OB), as well as 11 healthy controls 
      of normal weight (CON), underwent single voxel spectroscopy at 3 T. Spectra were 
      obtained within a region in the left parietal white matter one month before IGB 
      insertion, three months after IGB insertion, and one month after IGB removal. 
      Before IGB insertion, m-Ins/tCr was 15% higher in OD than in OB (p = 0.005) and 
      12% higher in OD than in CON (p = 0.03). m-Ins/tCr decreased significantly by 8% 
      over the first three months after IGB insertion (p = 0.01) and remained normal 
      after IGB removal. tNAA/tCr was normal in all groups throughout the study, 
      pointing to normal brain metabolism. Normalization of m-Ins/tCr is consistent 
      with remission of neuroinflammation in patients with T2DM. An evaluation of 
      long-term effects of IGB treatment is necessary.
CI  - (c) 2018 John Wiley & Sons, Ltd.
FAU - Gazdzinski, Stefan P
AU  - Gazdzinski SP
AUID- ORCID: 0000-0003-0740-8765
AD  - CNS Lab, Military Institute of Aviation Medicine, Warsaw, Poland.
FAU - Gazdzinska, Agata P
AU  - Gazdzinska AP
AD  - Department of Nutrition and Obesity, Military Institute of Aviation Medicine, 
      Warsaw, Poland.
FAU - Orzel, Jaroslaw
AU  - Orzel J
AD  - Department of Radioelectronics, Warsaw University of Technology, Warsaw, Poland.
FAU - Redlisz-Redlicki, Grzegorz
AU  - Redlisz-Redlicki G
AD  - Department of Surgery, Military Institute of Aviation Medicine, Warsaw, Poland.
FAU - Pietruszka, Maciej
AU  - Pietruszka M
AD  - Department of Surgery, Military Institute of Aviation Medicine, Warsaw, Poland.
FAU - Mojkowska, Aleksandra
AU  - Mojkowska A
AD  - Department of Surgery, Military Institute of Aviation Medicine, Warsaw, Poland.
FAU - Pacho, Ryszard A
AU  - Pacho RA
AD  - Department of Radiology, Military Institute of Aviation Medicine, Warsaw, Poland.
FAU - Wylezol, Mariusz
AU  - Wylezol M
AD  - Department of Surgery, Military Institute of Aviation Medicine, Warsaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180716
PL  - England
TA  - NMR Biomed
JT  - NMR in biomedicine
JID - 8915233
RN  - 4L6452S749 (Inositol)
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Body Mass Index
MH  - Body Weight
MH  - Brain/*diagnostic imaging
MH  - Creatine/metabolism
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - *Gastric Balloon
MH  - Humans
MH  - Inositol/metabolism
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Metabolome
MH  - Middle Aged
MH  - Obesity, Morbid/*complications/*therapy
OTO - NOTNLM
OT  - bariatric therapy
OT  - brain
OT  - intra-gastric balloon
OT  - morbid obesity
OT  - myo-inositol
OT  - type 2 diabetes mellitus
EDAT- 2018/07/17 06:00
MHDA- 2019/02/26 06:00
CRDT- 2018/07/17 06:00
PHST- 2017/12/18 00:00 [received]
PHST- 2018/05/11 00:00 [revised]
PHST- 2018/05/16 00:00 [accepted]
PHST- 2018/07/17 06:00 [pubmed]
PHST- 2019/02/26 06:00 [medline]
PHST- 2018/07/17 06:00 [entrez]
AID - 10.1002/nbm.3957 [doi]
PST - ppublish
SO  - NMR Biomed. 2018 Sep;31(9):e3957. doi: 10.1002/nbm.3957. Epub 2018 Jul 16.