PMID- 30011792
OWN - NLM
STAT- MEDLINE
DCOM- 20181106
LR  - 20181114
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 7
DP  - 2018 Jul 13
TI  - Role of Damage Associated Molecular Pattern Molecules (DAMPs) in Aneurysmal 
      Subarachnoid Hemorrhage (aSAH).
LID - 10.3390/ijms19072035 [doi]
LID - 2035
AB  - Aneurysmal subarachnoid hemorrhage (aSAH) represents only a small portion of all 
      strokes, but accounts for almost half of the deaths caused by stroke worldwide. 
      Neurosurgical clipping and endovascular coiling can successfully obliterate the 
      bleeding aneurysms, but ensuing complications such as cerebral vasospasm, acute 
      and chronic hydrocephalus, seizures, cortical spreading depression, delayed 
      ischemic neurological deficits, and delayed cerebral ischemia lead to poor 
      clinical outcomes. The mechanisms leading to these complications are complex and 
      poorly understood. Early brain injury resulting from transient global ischemia 
      can release molecules that may be critical to initiate and sustain inflammatory 
      response. Hence, the events during early brain injury can influence the 
      occurrence of delayed brain injury. Since the damage associated molecular pattern 
      molecules (DAMPs) might be the initiators of inflammation in the pathophysiology 
      of aSAH, so the aim of this review is to highlight their role in the context of 
      aSAH from diagnostic, prognostic, therapeutic, and drug therapy monitoring 
      perspectives. DAMPs represent a diverse and a heterogenous group of molecules 
      derived from different compartments of cells upon injury. Here, we have reviewed 
      the most important DAMPs molecules including high mobility group box-1 (HMGB1), 
      S100B, hemoglobin and its derivatives, extracellular matrix components, IL-1alpha, 
      IL-33, and mitochondrial DNA in the context of aSAH and their role in post-aSAH 
      complications and clinical outcome after aSAH.
FAU - Chaudhry, Shafqat Rasul
AU  - Chaudhry SR
AD  - Department of Neurosurgery, University Hospital Bonn, University of Bonn, 
      Sigmund-Freud Str. 25, D-53105 Bonn, Germany. shafqatrasul@yahoo.com.
AD  - Department of Pharmaceutics, Institute of Pharmacy, University of Bonn, 
      Gerhard-Domagk-Strasse 3, D-53121 Bonn, Germany. shafqatrasul@yahoo.com.
FAU - Hafez, Ahmad
AU  - Hafez A
AD  - Department of Neurosurgery, University of Helsinki and Helsinki University 
      Hospital, 266, FI-00029 Helsinki, Finland. ext-ahmad.hafez@hus.fi.
FAU - Rezai Jahromi, Behnam
AU  - Rezai Jahromi B
AUID- ORCID: 0000-0003-3937-2816
AD  - Department of Neurosurgery, University of Helsinki and Helsinki University 
      Hospital, 266, FI-00029 Helsinki, Finland. behnam.rezai-jahromi@hus.fi.
FAU - Kinfe, Thomas Mehari
AU  - Kinfe TM
AD  - Department of Neurosurgery, University Hospital Bonn, University of Bonn, 
      Sigmund-Freud Str. 25, D-53105 Bonn, Germany. Thomas.Kinfe@ukb.uni-bonn.de.
FAU - Lamprecht, Alf
AU  - Lamprecht A
AD  - Department of Pharmaceutics, Institute of Pharmacy, University of Bonn, 
      Gerhard-Domagk-Strasse 3, D-53121 Bonn, Germany. alf.lamprecht@uni-bonn.de.
FAU - Niemela, Mika
AU  - Niemela M
AD  - Department of Neurosurgery, University of Helsinki and Helsinki University 
      Hospital, 266, FI-00029 Helsinki, Finland. mika.niemela@hus.fi.
FAU - Muhammad, Sajjad
AU  - Muhammad S
AUID- ORCID: 0000-0002-6734-7979
AD  - Department of Neurosurgery, University Hospital Bonn, University of Bonn, 
      Sigmund-Freud Str. 25, D-53105 Bonn, Germany. ext-sajjad.muhammad@hus.fi.
AD  - Department of Neurosurgery, University of Helsinki and Helsinki University 
      Hospital, 266, FI-00029 Helsinki, Finland. ext-sajjad.muhammad@hus.fi.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180713
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Alarmins)
RN  - 0 (Cytokines)
SB  - IM
MH  - Alarmins/*metabolism
MH  - Brain Diseases/complications/metabolism
MH  - Cytokines/metabolism
MH  - Humans
MH  - Inflammation/complications/*metabolism
MH  - Models, Biological
MH  - Prognosis
MH  - Stroke/complications/*metabolism
MH  - Subarachnoid Hemorrhage/complications/diagnosis/*metabolism
PMC - PMC6073937
OTO - NOTNLM
OT  - IL-1alpha
OT  - S100B
OT  - alarmins
OT  - danger associated molecular pattern molecules (DAMPs)
OT  - heat shock proteins
OT  - hemoglobin
OT  - high mobility group box-1 (HMGB1)
OT  - interleukin (IL)-33
OT  - mitochondrial DNA
OT  - subarachnoid hemorrhage
COIS- The authors declare no conflicts of interest.
EDAT- 2018/07/18 06:00
MHDA- 2018/11/07 06:00
PMCR- 2018/07/01
CRDT- 2018/07/18 06:00
PHST- 2018/06/21 00:00 [received]
PHST- 2018/07/01 00:00 [revised]
PHST- 2018/07/09 00:00 [accepted]
PHST- 2018/07/18 06:00 [entrez]
PHST- 2018/07/18 06:00 [pubmed]
PHST- 2018/11/07 06:00 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - ijms19072035 [pii]
AID - ijms-19-02035 [pii]
AID - 10.3390/ijms19072035 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Jul 13;19(7):2035. doi: 10.3390/ijms19072035.