PMID- 30013602
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1734-1922 (Print)
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 14
IP  - 4
DP  - 2018 Jun
TI  - Glycoprotein Ibalpha Kozak polymorphism in patients presenting with early-onset acute 
      coronary syndrome.
PG  - 788-793
LID - 10.5114/aoms.2016.63278 [doi]
AB  - INTRODUCTION: Glycoprotein Ibalpha (GPIbalpha) receptor is the chief molecule responsible 
      for initial platelet adhesion to the subendothelium. A thymidine to cytosine 
      single nucleotide substitution at position -5 from the ATG start codon 
      characterizes the Kozak sequence polymorphism. The Kozak sequence polymorphism 
      may increase the surface expression of GPIbalpha and contribute to thrombogenesis. We 
      evaluated the allele frequencies of GPIbalpha Kozak sequence polymorphism in the 
      Turkish population and examined the relationship between GPIbalpha Kozak sequence 
      polymorphism and early-onset acute coronary syndrome (ACS). MATERIAL AND METHODS: 
      This study enrolled 200 patients (122 male, 78 female, mean age: 39 +/-5 years) and 
      200 healthy control subjects (110 male, 90 female, 41 +/-4 years). The patient 
      group was composed of patients admitted to our coronary care unit with 
      early-onset ACS and patients who attended to our cardiology outpatient clinic 
      after hospital discharge with a diagnosis of early-onset ACS. RESULTS: Kozak 
      polymorphism frequencies in patients and control subjects did not differ 
      significantly (23% versus 22.5%, p = 0.812, respectively). In patients who 
      presented with non-ST elevation myocardial infarction (NSTEMI), the frequency of 
      GPIbalpha Kozak polymorphism was borderline significantly higher when compared with 
      patients who presented with ST elevation myocardial infarction (STEMI) (35% vs. 
      20%, p = 0.05, respectively). Allele frequencies of T and C were calculated to be 
      0.873 and 0.128. CONCLUSIONS: Although the frequency of GPIbalpha Kozak polymorphism 
      did not differ significantly in early-onset ACS patients versus control subjects, 
      Kozak polymorphism frequency was borderline significantly higher in patients who 
      presented with NSTEMI when compared to patients with STEMI.
FAU - Golcuk, Ebru
AU  - Golcuk E
AD  - Department of Cardiology, Bayrampasa Kolan Hospital, Istanbul, Turkey.
FAU - Yalin, Kivanc
AU  - Yalin K
AD  - Department of Cardiology, Bayrampasa Kolan Hospital, Istanbul, Turkey.
FAU - Akdeniz, Cansu Selcan
AU  - Akdeniz CS
AD  - Department of Cardiology, Faculty of Medicine, Istanbul Bilim University, 
      Istanbul, Turkey.
FAU - Teker, Erhan
AU  - Teker E
AD  - Cardiology Clinic, Giresun State Hospital, Giresun, Turkey.
FAU - Teker, Basak
AU  - Teker B
AD  - Department of Molecular Genetics, Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Hancer, Veysel Sabri
AU  - Hancer VS
AD  - Department of Molecular Genetics, Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Altun, Ibrahim
AU  - Altun I
AD  - Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, 
      Mugla, Turkey.
FAU - Sezer, Murat
AU  - Sezer M
AD  - Department of Cardiology, Faculty of Medicine, Istanbul University, Istanbul, 
      Turkey.
FAU - Kucukkaya, Reyhan Diz
AU  - Kucukkaya RD
AD  - Department of Internal Medicine-Hematology, Faculty of Medicine, Istanbul Bilim 
      University, Istanbul, Turkey.
FAU - Oncul, Aytac
AU  - Oncul A
AD  - Department of Cardiology, Faculty of Medicine, Istanbul University, Istanbul, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20161026
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC6040121
OTO - NOTNLM
OT  - Turkish population
OT  - acute coronary syndrome
OT  - glycoprotein Ibalpha Kozak polymorphism
EDAT- 2018/07/18 06:00
MHDA- 2018/07/18 06:01
PMCR- 2018/06/01
CRDT- 2018/07/18 06:00
PHST- 2016/04/01 00:00 [received]
PHST- 2016/07/19 00:00 [accepted]
PHST- 2018/07/18 06:00 [entrez]
PHST- 2018/07/18 06:00 [pubmed]
PHST- 2018/07/18 06:01 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - 28613 [pii]
AID - 10.5114/aoms.2016.63278 [doi]
PST - ppublish
SO  - Arch Med Sci. 2018 Jun;14(4):788-793. doi: 10.5114/aoms.2016.63278. Epub 2016 Oct 
      26.