PMID- 30013647
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230926
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 16
IP  - 2
DP  - 2018 Aug
TI  - Delayed cognitive deficits can be alleviated by calcium antagonist nimodipine by 
      downregulation of apoptosis following whole brain radiotherapy.
PG  - 2525-2532
LID - 10.3892/ol.2018.8968 [doi]
AB  - Radiation therapy is important for the comprehensive treatment of intracranial 
      tumors. However, the molecular mechanisms underlying the pathogenesis of delayed 
      cognitive dysfunction are not well-defined and effective treatments or prevention 
      measures remain insufficient. In the present study, 60 adult male Wistar rats 
      were randomly divided into three groups, which included a control, whole brain 
      radiotherapy (WBRT) (single dose of 30 Gy of WBRT) and nimodipine (single dose of 
      30 Gy of WBRT followed by nimodipine injection intraperitoneally) groups. The 
      rats were sacrificed 7 days or 3 months following irradiation. At 3 months, the 
      Morris water maze test was used to assess spatial learning and memory function in 
      rats. The results demonstrated that the WBRT group demonstrated a significantly 
      impaired cognitive performance, decreased numbers of hippocampal Cornu Ammonis 
      (CA)1 neurons and upregulated expression of caspase-3 in the dentate gyrus 
      compared with those in the control and nimodipine groups. Reverse 
      transcription-quantitative polymerase chain reaction analysis demonstrated that 
      the WBRT group exhibited increased ratio of B-cell lymphoma 2 (Bcl-2)-associated 
      X protein (Bax)/Bcl-2 compared with that in control and nimodipine groups on day 
      7 following irradiation. However, the WBRT group exhibited decreased levels of 
      brain-derived neurotrophic factor (BDNF) compared with that in control and 
      nimodipine groups at 3 months following brain irradiation. The levels of 
      growth-associated protein 43 and amyloid precursor protein between the nimodipine 
      group and WBRT group were not statistically significant. The present study 
      demonstrated that neuron apoptosis may lead to delayed cognitive deficits in the 
      hippocampus, in response to radiotherapy. The cognitive impairment may be 
      alleviated in response to a calcium antagonist nimodipine. The molecular 
      mechanisms involved in nimodipine-mediated protection against cognitive decline 
      may involve the regulation of Bax/Bcl-2 and BDNF in the hippocampus.
FAU - Tong, Jing
AU  - Tong J
AD  - Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050011, P.R. China.
FAU - Li, Juan
AU  - Li J
AD  - Department of Radiotherapy, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050011, P.R. China.
FAU - Zhang, Qiu-Shi
AU  - Zhang QS
AD  - Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050011, P.R. China.
FAU - Yang, Jian-Kai
AU  - Yang JK
AD  - Department of Neurosurgery, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050011, P.R. China.
FAU - Liu, Hai-Ying
AU  - Liu HY
AD  - Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050011, P.R. China.
FAU - Liu, Ying-Zi
AU  - Liu YZ
AD  - Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050011, P.R. China.
FAU - Yuan, Jiang-Wei
AU  - Yuan JW
AD  - Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050011, P.R. China.
FAU - Su, Xu-Ming
AU  - Su XM
AD  - Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050011, P.R. China.
FAU - Zhang, Xue-Xin
AU  - Zhang XX
AD  - Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050011, P.R. China.
FAU - Jiao, Bao-Hua
AU  - Jiao BH
AD  - Department of Neurosurgery, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180613
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6036595
OTO - NOTNLM
OT  - calcium antagonist
OT  - cognitive deficit
OT  - hippocampus
OT  - neuron apoptosis
OT  - rat
OT  - whole brain radiation therapy
EDAT- 2018/07/18 06:00
MHDA- 2018/07/18 06:01
PMCR- 2018/06/13
CRDT- 2018/07/18 06:00
PHST- 2017/02/20 00:00 [received]
PHST- 2018/01/29 00:00 [accepted]
PHST- 2018/07/18 06:00 [entrez]
PHST- 2018/07/18 06:00 [pubmed]
PHST- 2018/07/18 06:01 [medline]
PHST- 2018/06/13 00:00 [pmc-release]
AID - OL-0-0-8968 [pii]
AID - 10.3892/ol.2018.8968 [doi]
PST - ppublish
SO  - Oncol Lett. 2018 Aug;16(2):2525-2532. doi: 10.3892/ol.2018.8968. Epub 2018 Jun 
      13.