PMID- 30014470
OWN - NLM
STAT- MEDLINE
DCOM- 20190102
LR  - 20190102
IS  - 1097-0010 (Electronic)
IS  - 0022-5142 (Linking)
VI  - 99
IP  - 1
DP  - 2019 Jan 15
TI  - Fermented goat milk consumption improves cardiovascular health during anemia 
      recovery.
PG  - 473-481
LID - 10.1002/jsfa.9210 [doi]
AB  - BACKGROUND: Iron (Fe) plays a crucial role in several fundamental processes, 
      including erythropoiesis, cellular metabolism, and in cardiovascular disease. The 
      aim of this work was to contribute to a better understanding of the physiology of 
      and recovery from Fe deficiency by studying how fermented milk consumption 
      affects vascular biomarkers during Fe repletion. RESULTS: The deleterious 
      cardiovascular biomarkers cytokine-induced neutrophil chemoattractant 1, 
      connective tissue growth factor (CTGF), interleukin-6, monocyte chemoattractant 
      protein-1 (MCP-1), inhibitor of tissue plasminogen activator 1 total, 
      metallopeptidase inhibitor 1 (TIMP-1), tumor necrosis factor alpha, vascular 
      endothelial growth factor (VEGF), sE-selectin, and soluble intercellular adhesion 
      molecule 1 (sICAM-1) decreased after fermented goat milk consumption in groups of 
      fed animals either with normal Fe or Fe overload with respect to rats fed with 
      fermented cow milk. The beneficial cardiovascular biomarkers caveolin-1 and 
      adiponectin were higher in both control and anemic rats fed fermented goat milk 
      either with normal Fe or Fe overload with respect to fermented cow milk. Anemia 
      decreased TIMP-1 in rats fed fermented goat milk with Fe overload, whereas there 
      was increased CTGF and MCP-1 in animals fed fermented cow milk with either normal 
      or Fe overload. In addition, Fe overload increased VEGF. CONCLUSION: Fermented 
      goat milk consumption improves hematological status and promotes beneficial 
      metabolic responses, which may attenuate cardiovascular risk factors during 
      anemia recovery and iron overload to lessen the inflammatory response, 
      macrophages activation and atherosclerosis development. (c) 2018 Society of 
      Chemical Industry.
CI  - (c) 2018 Society of Chemical Industry.
FAU - Munoz Alferez, M feminine Jose
AU  - Munoz Alferez MJ
AD  - Department of Physiology, University of Granada, Granada, Spain.
AD  - Institute of Nutrition and Food Technology "Jose Mataix Verdu", University of 
      Granada, Granada, Spain.
FAU - Munoz-Garcia, Alberto
AU  - Munoz-Garcia A
AUID- ORCID: 0000-0001-6475-6972
AD  - Department of Physiology, University of Granada, Granada, Spain.
AD  - Institute of Nutrition and Food Technology "Jose Mataix Verdu", University of 
      Granada, Granada, Spain.
FAU - Moreno-Fernandez, Jorge
AU  - Moreno-Fernandez J
AD  - Department of Physiology, University of Granada, Granada, Spain.
AD  - Institute of Nutrition and Food Technology "Jose Mataix Verdu", University of 
      Granada, Granada, Spain.
FAU - Lopez-Aliaga, Inmaculada
AU  - Lopez-Aliaga I
AUID- ORCID: 0000-0001-7627-8760
AD  - Department of Physiology, University of Granada, Granada, Spain.
AD  - Institute of Nutrition and Food Technology "Jose Mataix Verdu", University of 
      Granada, Granada, Spain.
FAU - Diaz-Castro, Javier
AU  - Diaz-Castro J
AUID- ORCID: 0000-0003-3659-1757
AD  - Department of Physiology, University of Granada, Granada, Spain.
AD  - Institute of Nutrition and Food Technology "Jose Mataix Verdu", University of 
      Granada, Granada, Spain.
LA  - eng
GR  - Consejeria de Economia, Innovacion, Ciencia y Empleo, Junta de Andalucia/
GR  - P11-AGR-7648/Andalusian Government, Excellence Research/
GR  - Ministry of Education, Culture and Sport (Spain)/
GR  - University of Granada/
PT  - Journal Article
DEP - 20180902
PL  - England
TA  - J Sci Food Agric
JT  - Journal of the science of food and agriculture
JID - 0376334
RN  - 0 (Chemokine CXCL1)
RN  - 0 (Cxcl1 protein, rat)
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 139568-91-5 (Connective Tissue Growth Factor)
SB  - IM
MH  - Anemia/*diet therapy/genetics/metabolism/physiopathology
MH  - Animals
MH  - Cardiovascular System/*metabolism/physiopathology
MH  - Chemokine CXCL1/genetics/metabolism
MH  - Connective Tissue Growth Factor/genetics/metabolism
MH  - Cultured Milk Products/*analysis/microbiology
MH  - Fermentation
MH  - Goats
MH  - Humans
MH  - Interleukin-6/genetics/metabolism
MH  - Lactobacillus delbrueckii/metabolism
MH  - Male
MH  - Milk/chemistry/*metabolism/microbiology
MH  - Rats, Wistar
MH  - Streptococcus thermophilus/metabolism
MH  - Vascular Endothelial Growth Factor A/genetics/metabolism
OTO - NOTNLM
OT  - cardiovascular cytokines
OT  - fermented milks
OT  - ferropenic anemia
OT  - iron overload
EDAT- 2018/07/18 06:00
MHDA- 2019/01/03 06:00
CRDT- 2018/07/18 06:00
PHST- 2018/04/03 00:00 [received]
PHST- 2018/06/18 00:00 [revised]
PHST- 2018/06/18 00:00 [accepted]
PHST- 2018/07/18 06:00 [pubmed]
PHST- 2019/01/03 06:00 [medline]
PHST- 2018/07/18 06:00 [entrez]
AID - 10.1002/jsfa.9210 [doi]
PST - ppublish
SO  - J Sci Food Agric. 2019 Jan 15;99(1):473-481. doi: 10.1002/jsfa.9210. Epub 2018 
      Sep 2.