PMID- 3001465
OWN - NLM
STAT- MEDLINE
DCOM- 19860218
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 38
IP  - 3
DP  - 1986 Jan 20
TI  - Dexamethasone suppresses pituitary-adrenal but not behavioral effects of 
      centrally administered CRF.
PG  - 211-6
AB  - Intracerebral ventricular (icv) administration of corticotropin-releasing factor 
      (CRF) significantly enhances the expression of stress-related behaviors in the 
      rat and also activates the pituitary-adrenal system. The pituitary-adrenal 
      response can be blocked by pretreatment of animals with dexamethasone. The 
      behavioral effects (motor activation, increased grooming and decreased eating) on 
      the other hand are resistant to suppression by dexamethasone. The independence of 
      the behavioral effects from activation of the pituitary-adrenal axis suggests 
      that stress-induced release of CRF could contribute to behavioral alterations 
      even in the presence of high concentrations of endogenous steroids.
FAU - Britton, D R
AU  - Britton DR
FAU - Varela, M
AU  - Varela M
FAU - Garcia, A
AU  - Garcia A
FAU - Rosenthal, M
AU  - Rosenthal M
LA  - eng
GR  - RR08139-10/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Endorphins)
RN  - 60617-12-1 (beta-Endorphin)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenocorticotropic Hormone/metabolism
MH  - Animals
MH  - Corticosterone/blood
MH  - Corticotropin-Releasing Hormone/*antagonists & inhibitors/pharmacology
MH  - Dexamethasone/administration & dosage/*pharmacology
MH  - Endorphins/metabolism
MH  - Feeding Behavior/drug effects
MH  - Grooming/drug effects
MH  - Injections, Intraventricular
MH  - Motor Activity/drug effects
MH  - Pituitary Gland, Anterior/metabolism
MH  - Pituitary-Adrenal System/*drug effects
MH  - Rats
MH  - Stress, Physiological/physiopathology
MH  - beta-Endorphin
EDAT- 1986/01/20 00:00
MHDA- 1986/01/20 00:01
CRDT- 1986/01/20 00:00
PHST- 1986/01/20 00:00 [pubmed]
PHST- 1986/01/20 00:01 [medline]
PHST- 1986/01/20 00:00 [entrez]
AID - 0024-3205(86)90305-X [pii]
AID - 10.1016/0024-3205(86)90305-x [doi]
PST - ppublish
SO  - Life Sci. 1986 Jan 20;38(3):211-6. doi: 10.1016/0024-3205(86)90305-x.