PMID- 30015149
OWN - NLM
STAT- MEDLINE
DCOM- 20181015
LR  - 20221207
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 60
DP  - 2018 Aug
TI  - Association between HLA alleles and lamotrigine-induced cutaneous adverse drug 
      reactions in Asian populations: A meta-analysis.
PG  - 163-171
LID - S1059-1311(18)30248-6 [pii]
LID - 10.1016/j.seizure.2018.06.024 [doi]
AB  - PURPOSE: The aim of this study was to assess the association between human 
      leukocyte antigen (HLA) variants and lamotrigine (LTG)-induced cutaneous adverse 
      drug reactions (cARDs). METHODS: A comprehensive literature search was conducted 
      on the relationship of HLA alleles with LTG-induced cADRs in Asian populations, 
      through PubMed, Embase, and Cochrane Library. The last search was in February 
      2018. The pooled odds ratio (OR) with 95% confidence interval (95% CI) was used 
      to access the strength of the association between an HLA allele and LTG-induced 
      cADRs. RESULTS: A total of 11 studies met the inclusion criteria and were 
      enrolled in our meta- analysis, which were based on Chinese, Korean, and Thai 
      populations. Among these populations, we observed that HLA-B*1502 is a risk 
      allele for LTG-induced Stevens-Johnson syndrome/toxic epidermal necrolysis 
      (SJS/TEN) in Chinese populations (pooled OR 2.4, 95% CI: 1.20-4.78, P = 0.01), 
      HLA-A*2402 was found to be a significant risk allele for both SJS/TEN (pooled OR 
      3.50, 95% CI: 1.61-7.59, P = 0.002) and maculopapular eruption (MPE) (pooled OR 
      2.14, 95% CI: 1.10-4.16, P = 0.03), and HLA-B*3303 was considered to be a 
      protective marker for MPE in Chinese and Korean populations (pooled OR 0.2, 95% 
      CI 0.06-0.64, P = 0.007). CONCLUSIONS: In Asian populations, HLA-B*1502 is a risk 
      factor for LTG-induced bullous lesions such as SJS/TEN in Chinese populations, 
      and HLA-A*2402 is associated with the susceptibility to either SJS/TEN or MPE. 
      HLA-A*3303 is a protective allele against LTG-induced MPE in Chinese and Korean 
      populations.
CI  - Copyright (c) 2018 British Epilepsy Association. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Deng, Yilun
AU  - Deng Y
AD  - Department of Neurology, West China Hospital of Sichuan University Chengdu, 
      Sichuan 610041, China.
FAU - Li, Shaoping
AU  - Li S
AD  - Department of Neurology, West China Hospital of Sichuan University Chengdu, 
      Sichuan 610041, China.
FAU - Zhang, Lin
AU  - Zhang L
AD  - Department of Neurology, West China Hospital of Sichuan University Chengdu, 
      Sichuan 610041, China.
FAU - Jin, Hou
AU  - Jin H
AD  - Department of Neurology, West China Hospital of Sichuan University Chengdu, 
      Sichuan 610041, China.
FAU - Zou, Xiaoyi
AU  - Zou X
AD  - Department of Neurology, West China Hospital of Sichuan University Chengdu, 
      Sichuan 610041, China. Electronic address: xiaoyizou@scu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20180707
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA Antigens)
RN  - 0 (Triazines)
RN  - U3H27498KS (Lamotrigine)
SB  - IM
MH  - Anticonvulsants/*adverse effects
MH  - Asian People/*genetics
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Lamotrigine
MH  - Pharmacogenomic Variants
MH  - Skin Diseases/*chemically induced/*genetics
MH  - Triazines/*adverse effects
OTO - NOTNLM
OT  - HLA
OT  - Lamotrigine
OT  - Maculopapular eruption
OT  - Stevens-Johnson syndrome
OT  - Toxic epidermal necrolysis
EDAT- 2018/07/18 06:00
MHDA- 2018/10/16 06:00
CRDT- 2018/07/18 06:00
PHST- 2018/04/18 00:00 [received]
PHST- 2018/06/06 00:00 [revised]
PHST- 2018/06/30 00:00 [accepted]
PHST- 2018/07/18 06:00 [pubmed]
PHST- 2018/10/16 06:00 [medline]
PHST- 2018/07/18 06:00 [entrez]
AID - S1059-1311(18)30248-6 [pii]
AID - 10.1016/j.seizure.2018.06.024 [doi]
PST - ppublish
SO  - Seizure. 2018 Aug;60:163-171. doi: 10.1016/j.seizure.2018.06.024. Epub 2018 Jul 
      7.