PMID- 30017425
OWN - NLM
STAT- MEDLINE
DCOM- 20190322
LR  - 20240229
IS  - 1872-9711 (Electronic)
IS  - 0161-813X (Linking)
VI  - 68
DP  - 2018 Sep
TI  - Molecular mechanisms of neuroprotective effect of adjuvant therapy with phenytoin 
      in pentylenetetrazole-induced seizures: Impact on Sirt1/NRF2 signaling pathways.
PG  - 47-65
LID - S0161-813X(18)30109-8 [pii]
LID - 10.1016/j.neuro.2018.07.006 [doi]
AB  - Current anticonvulsant therapies are principally aimed at suppressing neuronal 
      hyperexcitability to prevent or control the incidence of seizures. However, the 
      role of oxidative stress processes in seizures led to the proposition that 
      antioxidant compounds may be considered as promising candidates for limiting the 
      progression of epilepsy. Accordingly, the aim of this study is to determine if 
      coenzyme Q10 (CoQ10) and alpha-tocopherol (alpha-Toc) have a neuroprotective effect 
      in rats against the observed oxidative stress and inflammation during seizures 
      induced by pentylenetetrazole (PTZ) in rats, and to study their interactions with 
      the conventional antiseizure drug phenytoin (PHT), either alone or in 
      combination. Overall, the data revealed that alpha-Toc and CoQ10 supplementation can 
      ameliorate PTZ-induced seizures and recommended that nuclear factor erythroid 
      2-related factor 2 (NRF2) and silencing information regulator 1 (Sirt1) signaling 
      pathways may exemplify strategic molecular targets for seizure therapies. The 
      results of the present study provide novel mechanistic insights regarding the 
      protective effects of antioxidants and suggest an efficient therapeutic strategy 
      to attenuate seizures. Additionally, concurrent supplementation of CoQ10 and 
      alpha-Toc may be more effective than either antioxidant alone in decreasing 
      inflammation and oxidative stress in both cortical and hippocampal tissues. Also, 
      CoQ10 and alpha-Toc effectively reverse the PHT-mediated alterations in the brain 
      antioxidant status when compared to PHT only.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Nagib, Marwa M
AU  - Nagib MM
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Misr 
      International University, Cairo, Egypt. Electronic address: 
      marwa.naguib@miuegypt.edu.eg.
FAU - Tadros, Mariane G
AU  - Tadros MG
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams 
      University, Cairo, Egypt.
FAU - Al-Khalek, Hadwa Ali Abd
AU  - Al-Khalek HAA
AD  - Department of Histology and Cell biology, Faculty of Medicine, Ain Shams 
      University, Cairo, Egypt.
FAU - Rahmo, Rania M
AU  - Rahmo RM
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Misr 
      International University, Cairo, Egypt.
FAU - Sabri, Nagwa Ali
AU  - Sabri NA
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, 
      Cairo, Egypt.
FAU - Khalifa, Amani E
AU  - Khalifa AE
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams 
      University seconded to 57357 Children Cancer Hospital as the Scientific 
      Consultant for Pharmacy Affairs, Cairo, Egypt.
FAU - Masoud, Somaia I
AU  - Masoud SI
AD  - Former Head of Department of Clinical Pharmacology, Faculty of Medicine, Ain 
      Shams University, Cairo, Egypt.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20180711
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - H4N855PNZ1 (alpha-Tocopherol)
RN  - 0 (Anticonvulsants)
RN  - 0 (Antioxidants)
RN  - EJ27X76M46 (coenzyme Q10)
RN  - 0 (Neuroprotective Agents)
RN  - WM5Z385K7T (Pentylenetetrazole)
RN  - 6158TKW0C5 (Phenytoin)
RN  - EC 3.5.1.- (Sirt1 protein, rat)
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - 1339-63-5 (Ubiquinone)
RN  - 0 (NF-E2-Related Factor 2)
SB  - IM
RIN - Neurotoxicology. 2023 Jul;97:157. PMID: 37316402
MH  - Animals
MH  - Male
MH  - *alpha-Tocopherol/administration & dosage
MH  - *Anticonvulsants/administration & dosage
MH  - *Antioxidants/administration & dosage
MH  - Brain/drug effects/metabolism/pathology
MH  - Inflammation/chemically induced/metabolism
MH  - Neurons/drug effects/metabolism/pathology
MH  - *Neuroprotective Agents/administration & dosage
MH  - Oxidative Stress
MH  - *Pentylenetetrazole/administration & dosage
MH  - *Phenytoin/administration & dosage
MH  - Rats, Wistar
MH  - *Seizures/chemically induced/metabolism/prevention & control
MH  - Signal Transduction
MH  - Sirtuin 1/metabolism
MH  - *Ubiquinone/administration & dosage/analogs & derivatives
MH  - NF-E2-Related Factor 2/metabolism
OTO - NOTNLM
OT  - Alpha-tocopherol
OT  - Coenzyme Q10
OT  - Nuclear factor erythroid 2-related factor
OT  - Pentylenetetrazole
OT  - Sirt1
EDAT- 2018/07/19 06:00
MHDA- 2019/03/22 06:00
CRDT- 2018/07/19 06:00
PHST- 2018/04/06 00:00 [received]
PHST- 2018/06/22 00:00 [revised]
PHST- 2018/07/07 00:00 [accepted]
PHST- 2018/07/19 06:00 [pubmed]
PHST- 2019/03/22 06:00 [medline]
PHST- 2018/07/19 06:00 [entrez]
AID - S0161-813X(18)30109-8 [pii]
AID - 10.1016/j.neuro.2018.07.006 [doi]
PST - ppublish
SO  - Neurotoxicology. 2018 Sep;68:47-65. doi: 10.1016/j.neuro.2018.07.006. Epub 2018 
      Jul 11.