PMID- 30017710
OWN - NLM
STAT- MEDLINE
DCOM- 20190307
LR  - 20190307
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 685
DP  - 2018 Oct 15
TI  - Childhood trauma and emotion regulation: The moderator role of BDNF Val66Met.
PG  - 7-11
LID - S0304-3940(18)30487-7 [pii]
LID - 10.1016/j.neulet.2018.07.018 [doi]
AB  - Emotion regulation difficulties have been involved in multiple forms of 
      psychopathology and may represent an important focus for current efforts to 
      understand the biological mechanisms underlying transdiagnostic symptoms. The 
      present study investigated a gene-environment interaction (G x E) in reappraisal, 
      a form of emotion regulation that has been extensively linked to psychopathology. 
      In light of recent meta-analytic evidence of its consistent role in depression 
      and anxiety disorders, this study focused on the Val66Met (rs6265) 
      single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) 
      gene and examined its moderator role in the relation between childhood trauma and 
      reappraisal. A sample of N = 266 participants were genotyped for BDNF Val66Met, 
      filled in a self-report measure of childhood trauma, and underwent a cognitive 
      task designed to assess reappraisal ability. The results indicated that, as 
      expected, BDNF Val66Met was a significant moderator in the relation between 
      childhood trauma and reappraisal. There was a negative relation between the 
      number of childhood traumatic events and reappraisal ability in BDNF Met 
      carriers, but not Val homozygotes. This finding suggests that BDNF Val66Met 
      contributes to susceptibility to childhood stress, with long term impact on 
      emotion regulation.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Bilc, Mirela I
AU  - Bilc MI
AD  - Cognitive Neuroscience Laboratory, Department of Psychology, Babes-Bolyai 
      University, Cluj-Napoca, Cluj, Romania.
FAU - Vulturar, Romana
AU  - Vulturar R
AD  - Cognitive Neuroscience Laboratory, Department of Psychology, Babes-Bolyai 
      University, Cluj-Napoca, Cluj, Romania; Department of Molecular Sciences, Iuliu 
      Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Cluj, Romania.
FAU - Chis, Adina
AU  - Chis A
AD  - Cognitive Neuroscience Laboratory, Department of Psychology, Babes-Bolyai 
      University, Cluj-Napoca, Cluj, Romania; Department of Molecular Sciences, Iuliu 
      Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Cluj, Romania.
FAU - Buciuman, Madalina
AU  - Buciuman M
AD  - Cognitive Neuroscience Laboratory, Department of Psychology, Babes-Bolyai 
      University, Cluj-Napoca, Cluj, Romania.
FAU - Nutu, Daria
AU  - Nutu D
AD  - Cognitive Neuroscience Laboratory, Department of Psychology, Babes-Bolyai 
      University, Cluj-Napoca, Cluj, Romania.
FAU - Bunea, Ioana
AU  - Bunea I
AD  - Cognitive Neuroscience Laboratory, Department of Psychology, Babes-Bolyai 
      University, Cluj-Napoca, Cluj, Romania.
FAU - Szentagotai-Tatar, Aurora
AU  - Szentagotai-Tatar A
AD  - Department of Clinical Psychology and Psychotherapy, Babes-Bolyai University, 
      Cluj-Napoca, Cluj, Romania.
FAU - Miu, Andrei C
AU  - Miu AC
AD  - Cognitive Neuroscience Laboratory, Department of Psychology, Babes-Bolyai 
      University, Cluj-Napoca, Cluj, Romania. Electronic address: 
      andreimiu@psychology.ro.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180711
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child Abuse/psychology
MH  - Depression/*genetics/psychology
MH  - Depressive Disorder/genetics
MH  - Emotions/physiology
MH  - Female
MH  - *Gene-Environment Interaction
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Childhood trauma
OT  - Emotion regulation
OT  - Gene-environment interaction
OT  - Psychopathology
EDAT- 2018/07/19 06:00
MHDA- 2019/03/08 06:00
CRDT- 2018/07/19 06:00
PHST- 2018/01/29 00:00 [received]
PHST- 2018/07/09 00:00 [revised]
PHST- 2018/07/10 00:00 [accepted]
PHST- 2018/07/19 06:00 [pubmed]
PHST- 2019/03/08 06:00 [medline]
PHST- 2018/07/19 06:00 [entrez]
AID - S0304-3940(18)30487-7 [pii]
AID - 10.1016/j.neulet.2018.07.018 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 Oct 15;685:7-11. doi: 10.1016/j.neulet.2018.07.018. Epub 2018 
      Jul 11.