PMID- 30017781
OWN - NLM
STAT- MEDLINE
DCOM- 20190318
LR  - 20190318
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 88
DP  - 2019 Jan 10
TI  - Serum level of brain-derived neurotrophic factor in Parkinson's disease: a 
      meta-analysis.
PG  - 168-174
LID - S0278-5846(18)30126-X [pii]
LID - 10.1016/j.pnpbp.2018.07.010 [doi]
AB  - Brain-derived neurotrophic factor (BDNF), a critical modulator in the 
      neurodevelopment and maintenance of both central and peripheral nervous systems, 
      is regarded as a potential therapeutic target of Parkinson's disease (PD). 
      However, its association with PD remains unclear and the data are inconsistent. 
      To explore the correlation, studies reporting BDNF levels in PD patients and 
      healthy controls are searched and a sample of 1496 participants are pooled in the 
      meta-analysis, demonstrating significantly decreased serum levels of BDNF in PD 
      patients when compared with the healthy controls (SMD = -1.03; 95% CI [-1.83, 
      -0.23]; P = .012). Meta-regression analysis indicates gender is an important 
      confounding factor (Adj R(2) = 69.20%, p = .004, I(2) res = 90.64%), whereas age 
      (Adj R(2) = 11.91%, P = .95, I(2) res = 96.86%), H-Y stages of PD progression 
      (Adj R(2) = -30.18%, P = .612, I(2) res = 96.62%) and MoCA score assessed 
      cognitive impairment (Adj R(2) = 2.18%, P = .517, I(2) res = 64.41%) show few 
      moderating effects. The research provides evidence of moderate quality that blood 
      levels of BDNF are decreased in PD patients despite various influencing factors, 
      supporting an association between decreased level of peripheral BDNF and PD.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Jiang, Lina
AU  - Jiang L
AD  - Department of Neurology, The Second Xiangya Hospital, Central South University, 
      139 Middle Renmin Road, Changsha 410011, Hunan, China.
FAU - Zhang, Hainan
AU  - Zhang H
AD  - Department of Neurology, The Second Xiangya Hospital, Central South University, 
      139 Middle Renmin Road, Changsha 410011, Hunan, China.
FAU - Wang, Chunyu
AU  - Wang C
AD  - Department of Neurology, The Second Xiangya Hospital, Central South University, 
      139 Middle Renmin Road, Changsha 410011, Hunan, China.
FAU - Ming, Fengyu
AU  - Ming F
AD  - Department of Neurology, The Second Xiangya Hospital, Central South University, 
      139 Middle Renmin Road, Changsha 410011, Hunan, China.
FAU - Shi, Xiaoliu
AU  - Shi X
AD  - Department of Medical Genetics, The Second Xiangya Hospital, Central South 
      University, 139 Middle Renmin Road, Changsha 410011, Hunan, China.
FAU - Yang, Mei
AU  - Yang M
AD  - Department of Medical Genetics, The Second Xiangya Hospital, Central South 
      University, 139 Middle Renmin Road, Changsha 410011, Hunan, China. Electronic 
      address: yangmei23@csu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180711
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognition Disorders/*etiology
MH  - Humans
MH  - Parkinson Disease/*blood/complications
OTO - NOTNLM
OT  - BDNF
OT  - Parkinson's disease
OT  - Serum
EDAT- 2018/07/19 06:00
MHDA- 2019/03/19 06:00
CRDT- 2018/07/19 06:00
PHST- 2018/03/09 00:00 [received]
PHST- 2018/06/13 00:00 [revised]
PHST- 2018/07/10 00:00 [accepted]
PHST- 2018/07/19 06:00 [pubmed]
PHST- 2019/03/19 06:00 [medline]
PHST- 2018/07/19 06:00 [entrez]
AID - S0278-5846(18)30126-X [pii]
AID - 10.1016/j.pnpbp.2018.07.010 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jan 10;88:168-174. doi: 
      10.1016/j.pnpbp.2018.07.010. Epub 2018 Jul 11.