PMID- 30018546
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230928
IS  - 1662-5188 (Print)
IS  - 1662-5188 (Electronic)
IS  - 1662-5188 (Linking)
VI  - 12
DP  - 2018
TI  - Modulation of Spike-Timing Dependent Plasticity: Towards the Inclusion of a Third 
      Factor in Computational Models.
PG  - 49
LID - 10.3389/fncom.2018.00049 [doi]
LID - 49
AB  - In spike-timing dependent plasticity (STDP) change in synaptic strength depends 
      on the timing of pre- vs. postsynaptic spiking activity. Since STDP is in 
      compliance with Hebb's postulate, it is considered one of the major mechanisms of 
      memory storage and recall. STDP comprises a system of two coincidence detectors 
      with N-methyl-D-aspartate receptor (NMDAR) activation often posited as one of the 
      main components. Numerous studies have unveiled a third component of this 
      coincidence detection system, namely neuromodulation and glia activity shaping 
      STDP. Even though dopaminergic control of STDP has most often been reported, 
      acetylcholine, noradrenaline, nitric oxide (NO), brain-derived neurotrophic 
      factor (BDNF) or gamma-aminobutyric acid (GABA) also has been shown to 
      effectively modulate STDP. Furthermore, it has been demonstrated that astrocytes, 
      via the release or uptake of glutamate, gate STDP expression. At the most 
      fundamental level, the timing properties of STDP are expected to depend on the 
      spatiotemporal dynamics of the underlying signaling pathways. However in most 
      cases, due to technical limitations experiments grant only indirect access to 
      these pathways. Computational models carefully constrained by experiments, allow 
      for a better qualitative understanding of the molecular basis of STDP and its 
      regulation by neuromodulators. Recently, computational models of calcium dynamics 
      and signaling pathway molecules have started to explore STDP emergence in ex and 
      in vivo-like conditions. These models are expected to reproduce better at least 
      part of the complex modulation of STDP as an emergent property of the underlying 
      molecular pathways. Elucidation of the mechanisms underlying STDP modulation and 
      its consequences on network dynamics is of critical importance and will allow 
      better understanding of the major mechanisms of memory storage and recall both in 
      health and disease.
FAU - Foncelle, Alexandre
AU  - Foncelle A
AD  - INRIA, Villeurbanne, France.
AD  - LIRIS UMR 5205 CNRS-INSA, University of Lyon, Villeurbanne, France.
FAU - Mendes, Alexandre
AU  - Mendes A
AD  - Dynamic and Pathophysiology of Neuronal Networks, Center for Interdisciplinary 
      Research in Biology (CIRB), College de France, INSERM U1050, CNRS UMR7241, Labex 
      Memolife, Paris, France.
AD  - University Pierre et Marie Curie, ED 158, Paris, France.
FAU - Jedrzejewska-Szmek, Joanna
AU  - Jedrzejewska-Szmek J
AD  - The Krasnow Institute for Advanced Studies, George Mason University, Fairfax, VA, 
      United States.
FAU - Valtcheva, Silvana
AU  - Valtcheva S
AD  - Dynamic and Pathophysiology of Neuronal Networks, Center for Interdisciplinary 
      Research in Biology (CIRB), College de France, INSERM U1050, CNRS UMR7241, Labex 
      Memolife, Paris, France.
AD  - University Pierre et Marie Curie, ED 158, Paris, France.
FAU - Berry, Hugues
AU  - Berry H
AD  - INRIA, Villeurbanne, France.
AD  - LIRIS UMR 5205 CNRS-INSA, University of Lyon, Villeurbanne, France.
FAU - Blackwell, Kim T
AU  - Blackwell KT
AD  - The Krasnow Institute for Advanced Studies, George Mason University, Fairfax, VA, 
      United States.
FAU - Venance, Laurent
AU  - Venance L
AD  - Dynamic and Pathophysiology of Neuronal Networks, Center for Interdisciplinary 
      Research in Biology (CIRB), College de France, INSERM U1050, CNRS UMR7241, Labex 
      Memolife, Paris, France.
AD  - University Pierre et Marie Curie, ED 158, Paris, France.
LA  - eng
GR  - R01 DA003889/DA/NIDA NIH HHS/United States
GR  - R01 DA038890/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20180703
PL  - Switzerland
TA  - Front Comput Neurosci
JT  - Frontiers in computational neuroscience
JID - 101477956
PMC - PMC6037788
OTO - NOTNLM
OT  - Hebbian plasticity
OT  - STDP
OT  - acetylcholine
OT  - astrocytes
OT  - dopamine
OT  - eligibility traces
OT  - noradrenaline
OT  - third factor
EDAT- 2018/07/19 06:00
MHDA- 2018/07/19 06:01
PMCR- 2018/01/01
CRDT- 2018/07/19 06:00
PHST- 2018/03/15 00:00 [received]
PHST- 2018/06/06 00:00 [accepted]
PHST- 2018/07/19 06:00 [entrez]
PHST- 2018/07/19 06:00 [pubmed]
PHST- 2018/07/19 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fncom.2018.00049 [doi]
PST - epublish
SO  - Front Comput Neurosci. 2018 Jul 3;12:49. doi: 10.3389/fncom.2018.00049. 
      eCollection 2018.