PMID- 30018565
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 9
DP  - 2018
TI  - Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to 
      Neurodegenerative Events.
PG  - 806
LID - 10.3389/fphys.2018.00806 [doi]
LID - 806
AB  - The brain is one of the most exquisite organs in the body with high metabolic 
      demands, and requires a tight regulation of the surrounding environment. This 
      tight control is exerted by the neurovascular unit (NVU) comprising different 
      cell types, where endothelial cells play the commander-in-chief role. Thus, it is 
      assumable that even slight perturbations in NVU might affect, in some cases 
      irreversibly, brain homeostasis and health. In this line, recent findings support 
      the two-hit vascular hypothesis for neurodegenerative conditions, where vascular 
      dysfunction underlies the development of neurodegenerative diseases, such as 
      Alzheimer's disease (AD). Knowing that endothelial cells are rich in mitochondria 
      and nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, two major 
      reactive oxygen species (ROS) sources, this review aims to gather information on 
      how oxidative stress is in the front line of vascular alterations observed in 
      brain aging and neurodegenerative conditions, particularly AD. Also, a brief 
      discussion about the therapeutic strategies aimed to protect against 
      cerebrovascular diseases is included.
FAU - Carvalho, Cristina
AU  - Carvalho C
AD  - CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, 
      Portugal.
AD  - Institute for Interdisciplinary Research, University of Coimbra, Coimbra, 
      Portugal.
FAU - Moreira, Paula I
AU  - Moreira PI
AD  - CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, 
      Portugal.
AD  - Laboratory of Physiology, Faculty of Medicine, University of Coimbra, Coimbra, 
      Portugal.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180703
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6037979
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - NADPH oxidases
OT  - endothelial cells
OT  - mitochondria
OT  - neurovascular unit
OT  - oxidative stress
EDAT- 2018/07/19 06:00
MHDA- 2018/07/19 06:01
PMCR- 2018/07/03
CRDT- 2018/07/19 06:00
PHST- 2018/02/19 00:00 [received]
PHST- 2018/06/08 00:00 [accepted]
PHST- 2018/07/19 06:00 [entrez]
PHST- 2018/07/19 06:00 [pubmed]
PHST- 2018/07/19 06:01 [medline]
PHST- 2018/07/03 00:00 [pmc-release]
AID - 10.3389/fphys.2018.00806 [doi]
PST - epublish
SO  - Front Physiol. 2018 Jul 3;9:806. doi: 10.3389/fphys.2018.00806. eCollection 2018.