PMID- 30018728
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 10
IP  - 6
DP  - 2018
TI  - Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces 
      neuronal apoptosis in experimental traumatic brain injury possibly via the 
      Nrf2-ARE pathway.
PG  - 1887-1899
AB  - Mitoquinone (MitoQ) is a powerful mitochondrial-targeted antioxidant whose 
      neuroprotective effects have been shown in a variety of animal models of 
      neurological diseases. However, its roles in traumatic brain injury (TBI) remain 
      unexplored. The primary objective of this study was to investigate the 
      neuroprotection afforded by MitoQ in a mouse model of TBI, and the involvement of 
      the Nrf2-ARE signaling pathway in the putative neuroprotective mechanism. Mice 
      were randomly divided into four groups: sham group, TBI group, TBI + vehicle 
      group, and TBI + MitoQ group. MitoQ (4 mg/kg, administered intraperitoneally) or 
      an equal volume of vehicle was given at 30 min after TBI. After 24 h, brain 
      samples were harvested for analysis. The results demonstrated that treatment with 
      MitoQ significantly improved neurological deficits, alleviated brain edema and 
      inhibited cortical neuronal apoptosis. Furthermore, MitoQ administration 
      increased the activity of antioxidant enzymes, including superoxide dismutase 
      (SOD) and glutathione peroxidase (GPx), whereas it decreased the malondialdehyde 
      (MDA) content. In addition, MitoQ treatment reduced Bax protein translocation to 
      mitochondria and cytochrome c release into the cytosol. Moreover, MitoQ greatly 
      accelerated the Nrf2 nuclear translocation and subsequently upregulated the 
      expression of Nrf2 downstream proteins, including heme oxygenase-1 (HO-1) and 
      quinone oxidoreductase 1 (Nqo1). In conclusion, the results in the study 
      demonstrate that MitoQ exerts neuroprotective effects in the mouse model of TBI, 
      possibly by activating the Nrf2-ARE pathway.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Department of Neurosurgery, Jinling Hospital, Jinling Clinical Medical College, 
      Nanjing Medical University Nanjing 210002, Jiangsu Province, China.
AD  - Department of Neurosurgery, The First Affiliated Hospital of Hainan Medical 
      College Haikou 570102, Hainan Province, China.
FAU - Wang, Handong
AU  - Wang H
AD  - Department of Neurosurgery, Jinling Hospital, Jinling Clinical Medical College, 
      Nanjing Medical University Nanjing 210002, Jiangsu Province, China.
FAU - Shen, Ruiming
AU  - Shen R
AD  - Department of Rheumatology, The First Affiliated Hospital of Hainan Medical 
      College Haikou 570102, Hainan Province, China.
FAU - Fang, Jiang
AU  - Fang J
AD  - Department of Neurosurgery, Jinling Hospital, Medical College of Southeast 
      University Nanjing 210002, Jiangsu Province, China.
FAU - Yang, Youqin
AU  - Yang Y
AD  - Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical 
      University Xinxiang 453100, Henan Province, China.
FAU - Dai, Wei
AU  - Dai W
AD  - Department of Neurosurgery, Jinling Hospital, Jinling Clinical Medical College, 
      Nanjing Medical University Nanjing 210002, Jiangsu Province, China.
FAU - Zhu, Yihao
AU  - Zhu Y
AD  - Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing 
      University Nanjing 210002, Jiangsu Province, China.
FAU - Zhou, Mengliang
AU  - Zhou M
AD  - Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing 
      University Nanjing 210002, Jiangsu Province, China.
LA  - eng
PT  - Journal Article
DEP - 20180615
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC6038061
OTO - NOTNLM
OT  - Mitoquinone (MitoQ)
OT  - apoptosis
OT  - neuroprotection
OT  - nuclear factor erythroid 2-related factor 2
OT  - oxidative stress
OT  - traumatic brain injury
COIS- None.
EDAT- 2018/07/19 06:00
MHDA- 2018/07/19 06:01
PMCR- 2018/06/15
CRDT- 2018/07/19 06:00
PHST- 2018/01/21 00:00 [received]
PHST- 2018/05/03 00:00 [accepted]
PHST- 2018/07/19 06:00 [entrez]
PHST- 2018/07/19 06:00 [pubmed]
PHST- 2018/07/19 06:01 [medline]
PHST- 2018/06/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2018 Jun 15;10(6):1887-1899. eCollection 2018.