PMID- 3001880
OWN - NLM
STAT- MEDLINE
DCOM- 19860213
LR  - 20191029
IS  - 0181-1916 (Print)
IS  - 0181-1916 (Linking)
VI  - 25
IP  - 5
DP  - 1985
TI  - Biochemical modifications involved in the maturation of the ovine fetal adrenal 
      gland in late gestation: their modalities and regulation.
PG  - 963-76
AB  - During the last month of intra-uterine life, the steroidogenic response of the 
      ovine fetal adrenal glands to ACTH increases and becomes maximal at the time of 
      birth. This development involves modifications at different steps of the 
      adrenocorticotropic hormone (ACTH) action mechanism. It has been shown that the 
      enhanced capacity of the cells to produce cAMP is related to at least three 
      factors: an increased number of ACTH receptors, increased activity of the Ns 
      subunit of adenylate cyclase, and enhancement of guanosine 5'-triphosphate (GTP) 
      availability. The ability to produce pregnenolone and the activity of both 3 
      beta-hydroxy steroid dehydrogenase/isomerase and 17 alpha-hydroxylase are mainly 
      enhanced in the steroidogenic pathway. The infusion of ACTH for 5 days into 115 
      to 120-day old fetuses results in the development of most of these biochemical 
      process. Similarly, ACTH can induce maturation of cultured fetal adrenal cells 
      and some other proopiomelamocortin (POMC)-derived peptides can potentiate its 
      acute steroidogenic activity in vitro. However, even in the absence of ACTH, the 
      adenylate cyclase system and the steroidogenic potency of cultured cells increase 
      but to a lesser extent than when ACTH is present in the culture medium. It is 
      suggested that ACTH is the main trophic hormone of the ovine fetal adrenal during 
      the last month of gestation, even if other stimulatory factors may also be 
      important. The in vivo maturation of ovine fetal adrenal is blocked by the 
      presence of some unknown inhibitory factors in the fetal circulation which are of 
      likely extrapituitary origin.
FAU - Durand, P
AU  - Durand P
FAU - Cathiard, A M
AU  - Cathiard AM
FAU - Locatelli, A
AU  - Locatelli A
FAU - Saez, J M
AU  - Saez JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Reprod Nutr Dev (1980)
JT  - Reproduction, nutrition, developpement
JID - 8005903
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Receptors, Cell Surface)
RN  - 16960-16-0 (Cosyntropin)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - EC 4.6.1.1 (Adenylyl Cyclases)
SB  - IM
MH  - Adenylyl Cyclases/metabolism
MH  - Adrenal Cortex Hormones/biosynthesis
MH  - Adrenal Glands/drug effects/*embryology/enzymology/metabolism
MH  - Adrenocorticotropic Hormone/*analogs & derivatives/metabolism
MH  - Animals
MH  - Cells, Cultured
MH  - Cosyntropin/*pharmacology
MH  - Fetus/*physiology
MH  - Hypophysectomy
MH  - Pro-Opiomelanocortin/pharmacology
MH  - Receptors, Cell Surface/drug effects
MH  - Sheep
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.1051/rnd:19850711 [doi]
PST - ppublish
SO  - Reprod Nutr Dev (1980). 1985;25(5):963-76. doi: 10.1051/rnd:19850711.