PMID- 30020454
OWN - NLM
STAT- MEDLINE
DCOM- 20190528
LR  - 20190528
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 103
IP  - 9
DP  - 2018 Sep 1
TI  - One-Hour Postload Hyperglycemia: Implications for Prediction and Prevention of 
      Type 2 Diabetes.
PG  - 3131-3143
LID - 10.1210/jc.2018-00468 [doi]
AB  - CONTEXT: Recently, a value of 1-hour postload glucose concentration (1-h-PG) >/=155 
      mg/dL (8.6 mmol/L) in individuals with normal glucose tolerance (NGT) has been 
      found to be associated with an increased risk for future type 2 diabetes mellitus 
      (T2DM). In this review, we analyze the implication of 1-h-PG determination in 
      prediction of T2DM and cardiovascular disease. DESIGN: A literature search was 
      performed using MEDLINE. We included all English studies published up to February 
      2018 in peer-reviewed journals that examined the relationship between 1-h-PG and 
      diabetes, cardiometabolic alterations, organ damage, and cardiovascular disease. 
      RESULTS: Several longitudinal studies have consistently shown that 1-h-PG >/=155 
      mg/dL can recognize individuals at increased risk for future T2DM among subjects 
      with NGT. Additionally, we describe the pathophysiological abnormalities 
      associated with 1-h-PG >/=155 mg/dL including impaired insulin sensitivity, beta-cell 
      dysfunction, and increased glucose intestinal absorption, which are known to be 
      involved in T2DM pathogenesis. Importantly, numerous studies have demonstrated 
      that a value of 1-h-PG >/=155 mg/dL in individuals with NGT is not only linked to 
      an increased risk for future T2DM, but also able to identify those having a worse 
      cardiovascular phenotype and an increased risk of adverse cardiovascular 
      outcomes. CONCLUSIONS: Although 1-h-PG determination is not currently recommended 
      by the American Diabetes Association for identifying high-risk individuals, the 
      available evidence indicates that a value of 1-h-PG >/=155 mg/dL may be a useful 
      tool to recognize, among subjects with NGT, those at increased risk of T2DM and 
      cardiovascular disease.
FAU - Fiorentino, Teresa Vanessa
AU  - Fiorentino TV
AD  - Department of Medical and Surgical Sciences, University Magna Graecia of 
      Catanzaro, Viale Europa, Catanzaro, Italy.
FAU - Marini, Maria Adelaide
AU  - Marini MA
AD  - Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
FAU - Succurro, Elena
AU  - Succurro E
AD  - Department of Medical and Surgical Sciences, University Magna Graecia of 
      Catanzaro, Viale Europa, Catanzaro, Italy.
FAU - Andreozzi, Francesco
AU  - Andreozzi F
AD  - Department of Medical and Surgical Sciences, University Magna Graecia of 
      Catanzaro, Viale Europa, Catanzaro, Italy.
FAU - Perticone, Maria
AU  - Perticone M
AD  - Department of Experimental and Clinical Medicine, University Magna Graecia of 
      Catanzaro, Viale Europa, Catanzaro, Italy.
FAU - Hribal, Marta Letizia
AU  - Hribal ML
AD  - Department of Medical and Surgical Sciences, University Magna Graecia of 
      Catanzaro, Viale Europa, Catanzaro, Italy.
FAU - Sciacqua, Angela
AU  - Sciacqua A
AD  - Department of Medical and Surgical Sciences, University Magna Graecia of 
      Catanzaro, Viale Europa, Catanzaro, Italy.
FAU - Perticone, Francesco
AU  - Perticone F
AD  - Department of Medical and Surgical Sciences, University Magna Graecia of 
      Catanzaro, Viale Europa, Catanzaro, Italy.
FAU - Sesti, Giorgio
AU  - Sesti G
AD  - Department of Medical and Surgical Sciences, University Magna Graecia of 
      Catanzaro, Viale Europa, Catanzaro, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Blood Glucose)
SB  - IM
CIN - J Clin Endocrinol Metab. 2019 Mar 1;104(3):674-675. PMID: 30239758
CIN - J Clin Endocrinol Metab. 2019 Mar 1;104(3):676-677. PMID: 30239916
MH  - Blood Glucose/analysis
MH  - Cardiovascular Diseases/blood/etiology
MH  - Diabetes Mellitus, Type 2/blood/*diagnosis/prevention & control
MH  - Glucose Tolerance Test/methods
MH  - Humans
MH  - Hyperglycemia/*blood/complications
MH  - Insulin Resistance/physiology
MH  - Prediabetic State/blood/diagnosis
MH  - Prognosis
EDAT- 2018/07/19 06:00
MHDA- 2019/05/29 06:00
CRDT- 2018/07/19 06:00
PHST- 2018/02/26 00:00 [received]
PHST- 2018/07/12 00:00 [accepted]
PHST- 2018/07/19 06:00 [pubmed]
PHST- 2019/05/29 06:00 [medline]
PHST- 2018/07/19 06:00 [entrez]
AID - 5055108 [pii]
AID - 10.1210/jc.2018-00468 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2018 Sep 1;103(9):3131-3143. doi: 10.1210/jc.2018-00468.