PMID- 30021040
OWN - NLM
STAT- MEDLINE
DCOM- 20190312
LR  - 20190312
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 49
IP  - 7
DP  - 2018 Jul 1
TI  - Normal Variation of Photoreceptor Outer Segment Volume With Age, Gender, 
      Refractive Error, and Vitreomacular Adhesion.
PG  - 523-527
LID - 10.3928/23258160-20180628-09 [doi]
AB  - BACKGROUND AND OBJECTIVE: Thickness and volume changes of the photoreceptor outer 
      segment (PROS) layer on spectral-domain optical coherence tomography (SD-OCT) 
      images are associated with various disease states. However, there are limited 
      data on normal anatomical variation. This study evaluates the correlation of PROS 
      volume with age, gender, refractive error, and presence of vitreomacular adhesion 
      (VMA) in healthy subjects. PATIENTS AND METHODS: SD-OCT scans of 68 normal eyes 
      were analyzed. The ellipsoid zone and the apical retinal pigment epithelium 
      boundary were segmented using an automated algorithm. The PROS volume was 
      calculated as the region bounded by these two layers within a 6-mm diameter 
      circle centered at the fovea. A general linear model was used for statistical 
      analysis. RESULTS: PROS volume increased with age to a significant degree (P = 
      .013). Gender, refractive error, and presence of VMA were insignificant factors. 
      CONCLUSION: PROS volume, as measured on routine SD-OCT, increases with age in 
      healthy subjects, after adjusting for gender, refractive error, and VMA. 
      [Ophthalmic Surg Lasers Imaging Retina. 2018;49:523-527.].
CI  - Copyright 2018, SLACK Incorporated.
FAU - Pakdel, Amir Reza
AU  - Pakdel AR
FAU - Mammo, Zaid
AU  - Mammo Z
FAU - Lee, Sieun
AU  - Lee S
FAU - Forooghian, Farzin
AU  - Forooghian F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Normal Distribution
MH  - Prospective Studies
MH  - Refractive Errors/*physiopathology
MH  - Retinal Diseases/*physiopathology
MH  - Retinal Photoreceptor Cell Outer Segment/*physiology
MH  - *Sex Factors
MH  - Tissue Adhesions
MH  - Tomography, Optical Coherence/methods
MH  - Vitreous Body/*physiopathology
MH  - Young Adult
EDAT- 2018/07/19 06:00
MHDA- 2019/03/13 06:00
CRDT- 2018/07/19 06:00
PHST- 2017/08/11 00:00 [received]
PHST- 2017/12/04 00:00 [accepted]
PHST- 2018/07/19 06:00 [entrez]
PHST- 2018/07/19 06:00 [pubmed]
PHST- 2019/03/13 06:00 [medline]
AID - 10.3928/23258160-20180628-09 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2018 Jul 1;49(7):523-527. doi: 
      10.3928/23258160-20180628-09.