PMID- 30021335 OWN - NLM STAT- MEDLINE DCOM- 20181102 LR - 20181102 IS - 1950-6007 (Electronic) IS - 0753-3322 (Linking) VI - 105 DP - 2018 Sep TI - Current advances of pharmacological properties of 7-chloro-4-(phenylselanyl) quinoline: Prevention of cognitive deficit and anxiety in Alzheimer's disease model. PG - 1006-1014 LID - S0753-3322(18)31293-9 [pii] LID - 10.1016/j.biopha.2018.06.049 [doi] AB - This study investigated the effect of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) at a dose of 1 mg/kg in memory impairment and anxiety in an Alzheimer's disease (AD) model induced by amyloid beta-peptide (Abeta) (fragment 25-35) in mice. The involvement of acetylcholinesterase (AChE) activity and lipid peroxidation in hippocampus and cerebral cortex was evaluated. Male Swiss mice were pretreated with 4-PSQ (1 mg/kg, intragastrically (i.g.), daily) for fourteen days. Thirty minutes after the first treatment with 4-PSQ, the animals received a single injection of Abeta (3 nmol/3 mul/per site, intracerebroventricular (i.c.v.)). Mice were submitted to the behavioral tasks (open-field, elevated plus maze, Barnes maze, object recognition and location, and step-down inhibitory avoidance tests) from the fifth day onwards. On the fifteenth day, blood was removed for analysis of biochemical markers (glucose, triglycerides, urea, aspartate (AST) and alanine (ALT) aminotrasferases), and cerebral cortex and hippocampus for determination of AChE activity and thiobarbituric acid reactive species (TBARS) levels. Abeta caused memory impairment, anxiogenic behavior, increased AChE activity in the cerebral structures and TBARS levels in the cerebral cortex. 4-PSQ was effective to protect against behavioral changes, AChE activity and TBARS levels. In conclusion, 4-PSQ protected against learning and memory impairment and anxiety in a mouse model of AD induced by Abeta, and anticholinesterase and antioxidant actions are involved in the pharmacological effect of the compound. CI - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved. FAU - Pinz, Mikaela P AU - Pinz MP AD - Programa de Pos-graduacao em Bioquimica e Bioprospeccao, Laboratorio de Pesquisa em Farmacologia Bioquimica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), CEP 96010-900, Pelotas, RS, Brazil. FAU - Dos Reis, Angelica S AU - Dos Reis AS AD - Programa de Pos-graduacao em Bioquimica e Bioprospeccao, Laboratorio de Pesquisa em Farmacologia Bioquimica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), CEP 96010-900, Pelotas, RS, Brazil. FAU - Vogt, Ane G AU - Vogt AG AD - Programa de Pos-graduacao em Bioquimica e Bioprospeccao, Laboratorio de Pesquisa em Farmacologia Bioquimica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), CEP 96010-900, Pelotas, RS, Brazil. FAU - Kruger, Roberta AU - Kruger R AD - Programa de Pos-Graduacao em Quimica, Laboratorio de Sintese Organica Limpa - LASOL, Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), P.O. Box 354, 96010-900, Pelotas, RS, Brazil. FAU - Alves, Diego AU - Alves D AD - Programa de Pos-Graduacao em Quimica, Laboratorio de Sintese Organica Limpa - LASOL, Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), P.O. Box 354, 96010-900, Pelotas, RS, Brazil. FAU - Jesse, Cristiano R AU - Jesse CR AD - Laboratorio de Avaliacoes Farmacologicas e Toxicologicas Aplicadas as Moleculas Bioativas, LaftamBio Pampa, Universidade Federal do Pampa, CEP 97650-000, Itaqui, RS, Brazil. FAU - Roman, Silvane S AU - Roman SS AD - Universidade Regional Integrada, Campus Erechim, CEP 99700-000, RS, Brazil. FAU - Soares, Mauro P AU - Soares MP AD - Laboratorio Regional de Diagnostico Faculdade de Veterinaria, Universidade Federal de Pelotas, Capao do Leao, CEP: 96010-900, RS, Brazil. FAU - Wilhelm, Ethel A AU - Wilhelm EA AD - Programa de Pos-graduacao em Bioquimica e Bioprospeccao, Laboratorio de Pesquisa em Farmacologia Bioquimica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), CEP 96010-900, Pelotas, RS, Brazil. Electronic address: ethelwilhelm@yahoo.com.br. FAU - Luchese, Cristiane AU - Luchese C AD - Programa de Pos-graduacao em Bioquimica e Bioprospeccao, Laboratorio de Pesquisa em Farmacologia Bioquimica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Universidade Federal de Pelotas (UFPel), CEP 96010-900, Pelotas, RS, Brazil. Electronic address: cristiane_luchese@yahoo.com.br. LA - eng PT - Journal Article DEP - 20180619 PL - France TA - Biomed Pharmacother JT - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JID - 8213295 RN - 0 (7-chloro-4-phenylsulfonyl quinoline) RN - 0 (Amyloid beta-Peptides) RN - 0 (Peptide Fragments) RN - 0 (Quinolines) RN - 0 (amyloid beta-protein (25-35)) SB - IM MH - Alzheimer Disease/chemically induced/*drug therapy/metabolism MH - Amyloid beta-Peptides/*toxicity MH - Animals MH - Anxiety/chemically induced/metabolism/*prevention & control MH - Cognitive Dysfunction/chemically induced/metabolism/*prevention & control MH - *Disease Models, Animal MH - Locomotion/drug effects/physiology MH - Male MH - Maze Learning/drug effects/physiology MH - Mice MH - Peptide Fragments/*toxicity MH - Quinolines/pharmacology/*therapeutic use MH - Random Allocation OTO - NOTNLM OT - Anticholinesterase OT - Antioxidant OT - Anxiety OT - Memory OT - Quinoline OT - Selenium EDAT- 2018/07/20 06:00 MHDA- 2018/11/06 06:00 CRDT- 2018/07/20 06:00 PHST- 2018/02/26 00:00 [received] PHST- 2018/06/11 00:00 [revised] PHST- 2018/06/12 00:00 [accepted] PHST- 2018/07/20 06:00 [entrez] PHST- 2018/07/20 06:00 [pubmed] PHST- 2018/11/06 06:00 [medline] AID - S0753-3322(18)31293-9 [pii] AID - 10.1016/j.biopha.2018.06.049 [doi] PST - ppublish SO - Biomed Pharmacother. 2018 Sep;105:1006-1014. doi: 10.1016/j.biopha.2018.06.049. Epub 2018 Jun 19.