PMID- 30021358
OWN - NLM
STAT- MEDLINE
DCOM- 20181102
LR  - 20181102
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 105
DP  - 2018 Sep
TI  - Therapeutic effect of vitamin B(3) on hyperglycemia, oxidative stress and DNA 
      damage in alloxan induced diabetic rat model.
PG  - 1223-1231
LID - S0753-3322(18)32878-6 [pii]
LID - 10.1016/j.biopha.2018.06.085 [doi]
AB  - Evidences in the form of experimental analysis and scientific investigations 
      suggest that oxidative stress embody an imperative role in the onset and 
      progression of type-2 diabetes mellitus (T2DM). Aberrant elevation in levels of 
      free radicals, as observed upon disease onset, and the subsequent reduction in 
      anti-oxidant defenses is pernicious to metabolic enzymes and cellular organelles. 
      Niacin (Vitamin B(3)) is an essential nutrient for humans and is considered to be 
      an important food additive for animals too. This research was conducted to 
      examine the effect of nutraceutical antioxidant on diabetic environment. This 
      important member of Vitamin B complex is a forerunner of nicotinamide adenine 
      dinucleotide (NAD) and also nicotinamide adenine dinucleotide phosphate (NADP), 
      both of them serving as coenzymes for several metabolic enzymes. This study 
      reports the effects of niacin supplementation in alloxan induced diabetic rats 
      divided into five groups. Diabetes induced rats were further treated with niacin 
      at two doses (10 and 15 mg /kg body weight) and compared with a control set of 
      diabetes without treatment. Niacin treatment showed recovery in almost all 
      parameters in a dose reliant pattern. A notable decline in oxidative stress 
      parameters with reductions in fasting blood glucose levels was observed. 
      Histological studies reveal damage recovery in the liver as well as kidney 
      tissues. A notable amount of recovery was observed in cellular DNA damage. As a 
      deduction, it is advocated that dietary niacin supplementation might help in 
      reducing problems associated with diabetes. A probable mechanism pertaining to 
      the action of niacin is proposed as well.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Abdullah, K M
AU  - Abdullah KM
AD  - Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, 
      Aligarh 202002, India.
FAU - Alam, Md Maroof
AU  - Alam MM
AD  - Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, 
      Aligarh 202002, India.
FAU - Iqbal, Zarmin
AU  - Iqbal Z
AD  - Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, 
      Aligarh 202002, India.
FAU - Naseem, Imrana
AU  - Naseem I
AD  - Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, 
      Aligarh 202002, India. Electronic address: imrananaseem2009@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20180622
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 25X51I8RD4 (Niacinamide)
RN  - 6SW5YHA5NG (Alloxan)
SB  - IM
MH  - Alloxan/*pharmacology
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Blood Glucose/drug effects
MH  - DNA Damage/*drug effects
MH  - Diabetes Mellitus, Experimental/blood/*chemically induced/*drug therapy
MH  - Diabetes Mellitus, Type 2/blood/chemically induced/drug therapy
MH  - Dietary Supplements
MH  - Hyperglycemia/*drug therapy
MH  - Liver/drug effects
MH  - Male
MH  - Niacinamide/*pharmacology
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Alloxan
OT  - Diabetes
OT  - Hyperglycemia
OT  - Vitamin B3
EDAT- 2018/07/20 06:00
MHDA- 2018/11/06 06:00
CRDT- 2018/07/20 06:00
PHST- 2018/04/30 00:00 [received]
PHST- 2018/06/14 00:00 [revised]
PHST- 2018/06/14 00:00 [accepted]
PHST- 2018/07/20 06:00 [entrez]
PHST- 2018/07/20 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
AID - S0753-3322(18)32878-6 [pii]
AID - 10.1016/j.biopha.2018.06.085 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Sep;105:1223-1231. doi: 10.1016/j.biopha.2018.06.085. 
      Epub 2018 Jun 22.