PMID- 30021375
OWN - NLM
STAT- MEDLINE
DCOM- 20181102
LR  - 20181102
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 105
DP  - 2018 Sep
TI  - Synergistic effect of glucosamine and vitamin E against experimental rheumatoid 
      arthritis in neonatal rats.
PG  - 835-840
LID - S0753-3322(18)30884-9 [pii]
LID - 10.1016/j.biopha.2018.05.136 [doi]
AB  - The effect of glucosamine and vitamin E against rheumatoid arthritis (RA) in a 
      neonatal rat model was investigated. Lipid peroxidation, superoxide dismutase 
      (SOD), catalase, reduced glutathione (GSH), glutathione peroxidase (Gpx), matrix 
      metalloproteinase-3 (MMP-3), prostaglandin E(2) (PGE(2)), ceruloplasmin, copper, 
      zinc, nitric oxide (NO), uric acid, inducible nitric oxide synthase (iNOS), and 
      nuclear factor-kappaB (NF-kappaB) levels were determined in control and rheumatoid 
      arthritis neonatal rats. Glucosamine plus vitamin E supplementation reduced the 
      MDA level by 61.9% and increased the SOD, catalase, GSH, Gpx, and zinc levels. 
      MMP-3, PGE(2), ceruloplasmin, copper, NO and uric acid levels were significantly 
      reduced by supplementation of glucosamine plus vitamin E. NF-kappaB, and iNOS protein 
      levels were decreased by 47.7% and 39.5%, respectively, by glucosamine plus 
      vitamin E supplementation. Thus, supplementation with glucosamine plus vitamin E 
      exerted a synergistic effect against RA.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Dai, Wei
AU  - Dai W
AD  - Department of Pediatric Rheumatic Immunology, Wuhan Children's Hospital 
      Affiliated to Tongji Medical College, Huazhong University of Science and 
      Technology, Wuhan, Hubei 430000, China. Electronic address: 
      WandanCampbellmk@yahoo.com.
FAU - Qi, Chang
AU  - Qi C
AD  - Department of Nephrology, Wuhan Children's Hospital Affiliated to Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, 
      China.
FAU - Wang, Shasha
AU  - Wang S
AD  - Department of Pediatric Rheumatic Immunology, Wuhan Children's Hospital 
      Affiliated to Tongji Medical College, Huazhong University of Science and 
      Technology, Wuhan, Hubei 430000, China.
LA  - eng
PT  - Journal Article
DEP - 20180618
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Antioxidants)
RN  - 1406-18-4 (Vitamin E)
RN  - 9007-81-2 (Freund's Adjuvant)
RN  - N08U5BOQ1K (Glucosamine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antioxidants/*administration & dosage
MH  - Arthritis, Rheumatoid/chemically induced/*drug therapy/*metabolism
MH  - Cells, Cultured
MH  - Drug Synergism
MH  - Drug Therapy, Combination
MH  - Freund's Adjuvant/toxicity
MH  - Glucosamine/*administration & dosage
MH  - Lipid Peroxidation/drug effects/physiology
MH  - Male
MH  - Oxidative Stress/*drug effects/physiology
MH  - Rats
MH  - Treatment Outcome
MH  - Vitamin E/*administration & dosage
OTO - NOTNLM
OT  - Glucosamine
OT  - Neonatal rats
OT  - Rheumatoid arthritis
OT  - Synergistic effect
OT  - Vitamin E
EDAT- 2018/07/20 06:00
MHDA- 2018/11/06 06:00
CRDT- 2018/07/20 06:00
PHST- 2018/02/07 00:00 [received]
PHST- 2018/05/28 00:00 [revised]
PHST- 2018/05/28 00:00 [accepted]
PHST- 2018/07/20 06:00 [entrez]
PHST- 2018/07/20 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
AID - S0753-3322(18)30884-9 [pii]
AID - 10.1016/j.biopha.2018.05.136 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Sep;105:835-840. doi: 10.1016/j.biopha.2018.05.136. 
      Epub 2018 Jun 18.