PMID- 30022251
OWN - NLM
STAT- MEDLINE
DCOM- 20190125
LR  - 20190125
IS  - 1863-2661 (Electronic)
IS  - 1863-2653 (Linking)
VI  - 223
IP  - 8
DP  - 2018 Nov
TI  - Cell type-specific effects of BDNF in modulating dendritic architecture of 
      hippocampal neurons.
PG  - 3689-3709
LID - 10.1007/s00429-018-1715-0 [doi]
AB  - Brain-derived neurotrophin factor (BDNF) has been implicated in neuronal 
      survival, differentiation and activity-dependent synaptic plasticity in the 
      central nervous system. It was suggested that during postnatal development BDNF 
      regulates neuronal architecture and spine morphology of neurons within certain 
      brain areas but not others. Particularly striking are the differences between 
      striatum, cortex and hippocampus. Whether this is due to region- or cell 
      type-specific effects is so far not known. We address this question using 
      conditional bdnf knock-out mice to analyze neuronal architecture and spine 
      morphology of pyramidal cortical and hippocampal neurons as well as inhibitory 
      neurons from these brain areas and excitatory granule neurons from the dentate 
      gyrus. While hippocampal and cortical inhibitory neurons and granule cells of the 
      dentate gyrus are strongly impaired in their architecture, pyramidal neurons 
      within the same brain regions only show a mild phenotype. We found a reduced TrkB 
      phosphorylation within hippocampal interneurons and granule cells of the dentate 
      gyrus, accompanied by a significant decrease in dendritic complexity. In 
      contrast, in pyramidal neurons both TrkB phosphorylation and neuronal 
      architecture are not altered. The results suggest diverse levels of 
      responsiveness to BDNF for different hippocampal and cortical neuronal 
      populations within the same brain area. Among the possible mechanisms mediating 
      these differences in BDNF function, we tested whether zinc might be involved in 
      TrkB transactivation specifically in pyramidal neurons. We propose that a 
      BDNF-independent transactivation of TrkB receptor may be able to compensate the 
      lack of BDNF signaling to modulate neuronal morphology in a cell type-specific 
      manner.
FAU - Zagrebelsky, Marta
AU  - Zagrebelsky M
AD  - Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig, 
      Spielmannstr. 7, 38106, Brunswick, Germany. m.zagrebelsky@tu-bs.de.
FAU - Godecke, N
AU  - Godecke N
AD  - Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig, 
      Spielmannstr. 7, 38106, Brunswick, Germany.
FAU - Remus, A
AU  - Remus A
AD  - Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig, 
      Spielmannstr. 7, 38106, Brunswick, Germany.
AD  - Helmholtz Centre for Infection Research, AG NIND, Inhoffenstr. 7, 38124, 
      Brunswick, Germany.
FAU - Korte, Martin
AU  - Korte M
AUID- ORCID: 0000-0001-6956-5913
AD  - Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig, 
      Spielmannstr. 7, 38106, Brunswick, Germany. m.korte@tu-bs.de.
AD  - Helmholtz Centre for Infection Research, AG NIND, Inhoffenstr. 7, 38124, 
      Brunswick, Germany. m.korte@tu-bs.de.
LA  - eng
GR  - KO 1674/5-1/Deutsche Forschungsgemeinschaft/
PT  - Journal Article
DEP - 20180718
PL  - Germany
TA  - Brain Struct Funct
JT  - Brain structure & function
JID - 101282001
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Nerve Growth Factors)
RN  - 145172-44-7 (neurotrophin 5)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Cerebral Cortex/cytology/physiology
MH  - Dendrites/*physiology
MH  - GABAergic Neurons/cytology/physiology
MH  - Hippocampus/*cytology/physiology
MH  - Interneurons/cytology/physiology
MH  - Membrane Glycoproteins/physiology
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Nerve Growth Factors/physiology
MH  - Phosphorylation
MH  - Primary Cell Culture
MH  - Protein-Tyrosine Kinases/physiology
MH  - Transcriptional Activation
OTO - NOTNLM
OT  - Dendrites
OT  - Hippocampus
OT  - Spines
OT  - Structural plasticity
OT  - TrkB
OT  - Zinc
EDAT- 2018/07/20 06:00
MHDA- 2019/01/27 06:00
CRDT- 2018/07/20 06:00
PHST- 2018/01/16 00:00 [received]
PHST- 2018/07/09 00:00 [accepted]
PHST- 2018/07/20 06:00 [pubmed]
PHST- 2019/01/27 06:00 [medline]
PHST- 2018/07/20 06:00 [entrez]
AID - 10.1007/s00429-018-1715-0 [pii]
AID - 10.1007/s00429-018-1715-0 [doi]
PST - ppublish
SO  - Brain Struct Funct. 2018 Nov;223(8):3689-3709. doi: 10.1007/s00429-018-1715-0. 
      Epub 2018 Jul 18.