PMID- 30022827
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 14
DP  - 2018
TI  - Relation of high neuroticism with increased methylation of the BDNF gene.
PG  - 1787-1793
LID - 10.2147/NDT.S169787 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has 
      an important function in neuroplasticity and neuronal development. It is 
      suggested that increased methylation of the BDNF gene resulting in decreased BDNF 
      activity is associated with depression. Meanwhile, neuroticism is a well-known 
      risk factor for developing depression. In the present study, the relationship 
      between methylation of the BDNF gene and personality traits including neuroticism 
      was examined. SUBJECTS AND METHODS: The subjects were 98 healthy Japanese. 
      Methylation levels of the BDNF gene were determined by the 
      bisulfite-pyrosequencing method. Personality traits including neuroticism were 
      assessed by the NEO Personality Inventory-Revised. RESULTS: There was a positive 
      correlation between neuroticism scores and methylation levels of the BDNF gene. 
      The subjects with higher neuroticism scores had higher levels of BDNF gene 
      methylation compared with those with lower neuroticism scores. Meanwhile, other 
      personality traits were not associated with BDNF gene methylation. CONCLUSION: 
      The present study suggests that high neuroticism is related to increased 
      methylation of the BDNF gene.
FAU - Shirata, Toshinori
AU  - Shirata T
AD  - Department of Psychiatry, Yamagata University School of Medicine, Yamagata, 
      Japan, suzukiakihito@hotmail.com.
FAU - Suzuki, Akihito
AU  - Suzuki A
AD  - Department of Psychiatry, Yamagata University School of Medicine, Yamagata, 
      Japan, suzukiakihito@hotmail.com.
FAU - Matsumoto, Yoshihiko
AU  - Matsumoto Y
AD  - Department of Psychiatry, Yamagata University School of Medicine, Yamagata, 
      Japan, suzukiakihito@hotmail.com.
FAU - Takahashi, Nana
AU  - Takahashi N
AD  - Department of Psychiatry, Yamagata University School of Medicine, Yamagata, 
      Japan, suzukiakihito@hotmail.com.
FAU - Noto, Keisuke
AU  - Noto K
AD  - Department of Psychiatry, Yamagata University School of Medicine, Yamagata, 
      Japan, suzukiakihito@hotmail.com.
FAU - Goto, Kaoru
AU  - Goto K
AD  - Department of Anatomy and Cell Biology, Yamagata University School of Medicine, 
      Yamagata, Japan.
FAU - Otani, Koichi
AU  - Otani K
AD  - Department of Psychiatry, Yamagata University School of Medicine, Yamagata, 
      Japan, suzukiakihito@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20180709
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC6042484
OTO - NOTNLM
OT  - BDNF
OT  - depression
OT  - epigenetics
OT  - methylation
OT  - neuroticism
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2018/07/20 06:00
MHDA- 2018/07/20 06:01
PMCR- 2018/07/09
CRDT- 2018/07/20 06:00
PHST- 2018/07/20 06:00 [entrez]
PHST- 2018/07/20 06:00 [pubmed]
PHST- 2018/07/20 06:01 [medline]
PHST- 2018/07/09 00:00 [pmc-release]
AID - ndt-14-1787 [pii]
AID - 10.2147/NDT.S169787 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2018 Jul 9;14:1787-1793. doi: 10.2147/NDT.S169787. 
      eCollection 2018.