PMID- 30022843
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 11
DP  - 2018
TI  - Depression in people with type 2 diabetes: current perspectives.
PG  - 333-343
LID - 10.2147/DMSO.S106797 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is associated with depressive symptoms, and 
      comorbid depression in those with T2DM has been associated with adverse clinical 
      profiles. Recognizing and addressing psychological symptoms remain significant 
      clinical challenges in T2DM. Possible mediators of the reciprocal relationship 
      between T2DM and depression may include physical activity levels, effectiveness 
      of self-management, distress associated with a new T2DM diagnosis, and frailty 
      associated with advanced diabetes duration. The latter considerations contribute 
      to a "J-shaped" trajectory from the time of diagnosis. There remain significant 
      challenges to screening for clinical risks associated with psychological symptoms 
      in T2DM; poorer outcomes may be associated with major depressive episodes, 
      isolated (eg, anhedonic), or subsyndromal depressive symptoms, depressive-like 
      symptoms more specific to T2DM (eg, diabetes-related distress), apathy or 
      fatigue. In this review, we discuss current perspectives on depression in the 
      context of T2DM with implications for screening and management of these highly 
      comorbid conditions.
FAU - Darwish, Lina
AU  - Darwish L
AD  - Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, 
      Canada, w.swardfager@utoronto.ca.
AD  - Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, 
      Canada, w.swardfager@utoronto.ca.
AD  - Cardiac Rehabilitation Program, University Health Network Toronto Rehabilitation 
      Institute, Toronto, ON, Canada, w.swardfager@utoronto.ca.
AD  - Canadian Partnership for Stroke Recovery, Toronto, ON, Canada, 
      w.swardfager@utoronto.ca.
FAU - Beroncal, Erika
AU  - Beroncal E
AD  - Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, 
      Canada, w.swardfager@utoronto.ca.
AD  - Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, 
      Canada, w.swardfager@utoronto.ca.
AD  - Cardiac Rehabilitation Program, University Health Network Toronto Rehabilitation 
      Institute, Toronto, ON, Canada, w.swardfager@utoronto.ca.
FAU - Sison, Ma Veronica
AU  - Sison MV
AD  - Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, 
      Canada, w.swardfager@utoronto.ca.
AD  - Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, 
      Canada, w.swardfager@utoronto.ca.
AD  - Cardiac Rehabilitation Program, University Health Network Toronto Rehabilitation 
      Institute, Toronto, ON, Canada, w.swardfager@utoronto.ca.
FAU - Swardfager, Walter
AU  - Swardfager W
AD  - Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, 
      Canada, w.swardfager@utoronto.ca.
AD  - Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, 
      Canada, w.swardfager@utoronto.ca.
AD  - Cardiac Rehabilitation Program, University Health Network Toronto Rehabilitation 
      Institute, Toronto, ON, Canada, w.swardfager@utoronto.ca.
AD  - Canadian Partnership for Stroke Recovery, Toronto, ON, Canada, 
      w.swardfager@utoronto.ca.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180710
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC6044353
OTO - NOTNLM
OT  - complications
OT  - depression
OT  - mood
OT  - type 2 diabetes
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2018/07/20 06:00
MHDA- 2018/07/20 06:01
PMCR- 2018/07/10
CRDT- 2018/07/20 06:00
PHST- 2018/07/20 06:00 [entrez]
PHST- 2018/07/20 06:00 [pubmed]
PHST- 2018/07/20 06:01 [medline]
PHST- 2018/07/10 00:00 [pmc-release]
AID - dmso-11-333 [pii]
AID - 10.2147/DMSO.S106797 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2018 Jul 10;11:333-343. doi: 10.2147/DMSO.S106797. 
      eCollection 2018.