PMID- 30022870
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1226-2560 (Print)
IS  - 2093-8144 (Electronic)
IS  - 1226-2560 (Linking)
VI  - 27
IP  - 3
DP  - 2018 Jun
TI  - Antidepressant-like Effects of p-Coumaric Acid on LPS-induced Depressive and 
      Inflammatory Changes in Rats.
PG  - 189-199
LID - 10.5607/en.2018.27.3.189 [doi]
AB  - Depression causes mental and physical changes which affect quality of life. It is 
      estimated to become the second most prevalent disease, but despite its 
      commonness, the pathophysiology of depression remains unclear and medicine is not 
      sufficiently protective. p-Coumaric acid (p-CA) is a dietary phenolic acid which 
      has been proven to have antifungal, anti-HIV, anti-melanogenic, antioxidant and 
      anti-inflammatory effects. Considering these effects, we investigated whether 
      p-CA can prevent depressive symptoms by reducing inflammatory cytokines in 
      animals injected with lipopolysaccharide (LPS). Changes in despair-related 
      behaviors, inflammatory cytokines, neurotrophic factors and synaptic activity 
      were measured. In these animals, p-CA improved despair-related behavioral 
      symptoms induced by LPS in the forced swim test (FST), tail suspension test (TST) 
      and sucrose splash test (SST). p-CA also prevented the increase of inflammatory 
      cytokines in the hippocampus such as cycloxigenase-2 and tumor necrosis factor-alpha 
      due to LPS. Similarly, it prevented the reduction of brain-derived neurotrophic 
      factor (BDNF) by LPS. Electrophysiologically, p-CA blocked the reduction of 
      long-term depression in LPS-treated organotypic tissue slices. In conclusion, 
      p-CA prevented LPS-induced depressive symptoms in animals, as determined by 
      behavioral, biochemical and electrophysiological measures. These findings suggest 
      the potential use of p-CA as a preventive and therapeutic medicine for 
      depression.
FAU - Lee, Seok
AU  - Lee S
AD  - Department of East-West Medical Science, Graduate School of East-West Medical 
      Science, Kyung Hee University, Yongin 17104, Korea.
FAU - Kim, Hyun-Bum
AU  - Kim HB
AD  - Department of East-West Medical Science, Graduate School of East-West Medical 
      Science, Kyung Hee University, Yongin 17104, Korea.
FAU - Hwang, Eun-Sang
AU  - Hwang ES
AD  - Department of Gerontology, Graduate School of East-West Medical Science, Kyung 
      Hee University, Yongin 17104, Korea.
FAU - Kim, Eun-Seok
AU  - Kim ES
AD  - Department of East-West Medicine, Graduate School of East-West Medical Science, 
      Kyung Hee University, Yongin 17104, Korea.
FAU - Kim, Sung-Soo
AU  - Kim SS
AD  - Department of East-West Medicine, Graduate School of East-West Medical Science, 
      Kyung Hee University, Yongin 17104, Korea.
FAU - Jeon, Tae-Dong
AU  - Jeon TD
AD  - Department of East-West Medicine, Graduate School of East-West Medical Science, 
      Kyung Hee University, Yongin 17104, Korea.
FAU - Song, Min-Cheol
AU  - Song MC
AD  - Department of East-West Medical Science, Graduate School of East-West Medical 
      Science, Kyung Hee University, Yongin 17104, Korea.
FAU - Lee, Ji-Seung
AU  - Lee JS
AD  - Department of East-West Medical Science, Graduate School of East-West Medical 
      Science, Kyung Hee University, Yongin 17104, Korea.
FAU - Chung, Min-Chan
AU  - Chung MC
AD  - Department of East-West Medicine, Graduate School of East-West Medical Science, 
      Kyung Hee University, Yongin 17104, Korea.
FAU - Maeng, Sungho
AU  - Maeng S
AD  - Department of Gerontology, Graduate School of East-West Medical Science, Kyung 
      Hee University, Yongin 17104, Korea.
FAU - Park, Ji-Ho
AU  - Park JH
AD  - Department of East-West Medical Science, Graduate School of East-West Medical 
      Science, Kyung Hee University, Yongin 17104, Korea.
AD  - Research Institute of Medical Nutrition, Kyung Hee University, Yongin 17104, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20180630
PL  - Korea (South)
TA  - Exp Neurobiol
JT  - Experimental neurobiology
JID - 101278187
PMC - PMC6050412
OTO - NOTNLM
OT  - Cytokines
OT  - Depression
OT  - Lipopolysaccharide (LPS)
OT  - Long-term synaptic depression (LTD)
OT  - p-coumaric acid (p-CA)
EDAT- 2018/07/20 06:00
MHDA- 2018/07/20 06:01
PMCR- 2018/06/01
CRDT- 2018/07/20 06:00
PHST- 2018/05/18 00:00 [received]
PHST- 2018/06/17 00:00 [revised]
PHST- 2018/06/21 00:00 [accepted]
PHST- 2018/07/20 06:00 [entrez]
PHST- 2018/07/20 06:00 [pubmed]
PHST- 2018/07/20 06:01 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - 10.5607/en.2018.27.3.189 [doi]
PST - ppublish
SO  - Exp Neurobiol. 2018 Jun;27(3):189-199. doi: 10.5607/en.2018.27.3.189. Epub 2018 
      Jun 30.