PMID- 30023064
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 2050-6406 (Print)
IS  - 2050-6414 (Electronic)
IS  - 2050-6406 (Linking)
VI  - 6
IP  - 6
DP  - 2018 Jul
TI  - The distribution of HLA DQ2 and DQ8 haplotypes and their association with health 
      indicators in a general Danish population.
PG  - 866-878
LID - 10.1177/2050640618765506 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) DQ2 and DQ8 are important risk factors 
      for some autoimmune diseases such as celiac disease (CD), but their possible role 
      in other diseases and health conditions is not fully explored. OBJECTIVES: The 
      objective of this article is to examine the distribution of HLA DQ2 and HLA DQ8 
      in an adult general population, and their association with health indicators 
      (diseases, symptoms and biomarkers). METHODS: In this cross-sectional, 
      population-based study, 2293 individuals were screened for HLA DQ2 and DQ8; 
      CD-associated alleles (DQA*0201*03*05/DQB*02*0301/0304*0302/0305) and DQB1*02 
      homozygosity were determined for screen-positive participants. The National 
      Patient Registry provided diagnosis information. RESULTS: A total of 47.7% 
      (1093/2293) individuals were positive for DQ2 and/or DQ8: 31.2% (716/2293) only 
      DQ2, 11.9% (273/2293) only DQ8, 4.1% (93/2293) both DQ2 and DQ8. Among nine 
      individuals diagnosed with CD, 89.9% (8/9) had DQ2.5cis, 22.2% (2/9) DQ8 and 
      22.2% (2/9) DQ2.2 (two both DQ2 and DQ8). HLA DQ2.5 was associated with higher 
      thyroid-stimulating hormone levels, while DQ2/DQ8-positive participants had 
      significantly lower prevalence of irritable bowel syndrome (IBS). DQ2/DQ8 were 
      strongly associated with CD, but no other registry-based diagnoses. CONCLUSION: 
      In this general Danish population, 47.7% were HLA DQ2/DQ8 positive and thus 
      potentially at risk for CD. All individuals with CD were DQ2/DQ8 positive; the 
      majority DQ2.5. Surprisingly, DQ2/DQ8-positivity was associated with lower IBS 
      prevalence.
FAU - Karhus, Line Lund
AU  - Karhus LL
AD  - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg 
      Hospital, Capital Region, Copenhagen, Denmark.
AD  - Research Centre for Prevention and Health, The Capital Region, Copenhagen, 
      Denmark.
FAU - Thuesen, Betina H
AU  - Thuesen BH
AD  - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg 
      Hospital, Capital Region, Copenhagen, Denmark.
AD  - Research Centre for Prevention and Health, The Capital Region, Copenhagen, 
      Denmark.
FAU - Skaaby, Tea
AU  - Skaaby T
AD  - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg 
      Hospital, Capital Region, Copenhagen, Denmark.
AD  - Research Centre for Prevention and Health, The Capital Region, Copenhagen, 
      Denmark.
FAU - Rumessen, Juri J
AU  - Rumessen JJ
AD  - Q&D-Research Unit and Department of Gastroenterology, Herlev and Gentofte 
      Hospital, University of Copenhagen, Copenhagen, Denmark.
FAU - Linneberg, Allan
AU  - Linneberg A
AD  - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg 
      Hospital, Capital Region, Copenhagen, Denmark.
AD  - Research Centre for Prevention and Health, The Capital Region, Copenhagen, 
      Denmark.
AD  - Department of Clinical Medicine, Faculty of Health and Medical Sciences, 
      University of Copenhagen, Copenhagen, Denmark.
AD  - Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, 
      Denmark.
LA  - eng
PT  - Journal Article
DEP - 20180308
PL  - England
TA  - United European Gastroenterol J
JT  - United European gastroenterology journal
JID - 101606807
PMC - PMC6047278
OTO - NOTNLM
OT  - Celiac disease
OT  - HLA DQ2
OT  - HLA DQ8
OT  - epidemiology
EDAT- 2018/07/20 06:00
MHDA- 2018/07/20 06:01
PMCR- 2018/07/01
CRDT- 2018/07/20 06:00
PHST- 2017/12/29 00:00 [received]
PHST- 2018/02/21 00:00 [accepted]
PHST- 2018/07/20 06:00 [entrez]
PHST- 2018/07/20 06:00 [pubmed]
PHST- 2018/07/20 06:01 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - 10.1177_2050640618765506 [pii]
AID - 10.1177/2050640618765506 [doi]
PST - ppublish
SO  - United European Gastroenterol J. 2018 Jul;6(6):866-878. doi: 
      10.1177/2050640618765506. Epub 2018 Mar 8.