PMID- 30025100
OWN - NLM
STAT- MEDLINE
DCOM- 20190318
LR  - 20190318
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 59
IP  - 8
DP  - 2018 Jul 2
TI  - Significant Relationship of Visual Field Sensitivity in Central 10 degrees  to Thickness 
      of Retinal Layers in Retinitis Pigmentosa.
PG  - 3469-3475
LID - 10.1167/iovs.18-24635 [doi]
AB  - PURPOSE: To determine the relationship between the sensitivity of the retina in 
      the central 10 degrees  and the thickness of the retinal layers in patients with 
      retinitis pigmentosa (RP). METHODS: Fifty-two RP patients were studied. All of 
      the patients had been examined by the Humphrey Field Analyzer 10-2 program 
      (HFA10-2) and spectral-domain optical coherence tomography (SD-OCT). The 
      thicknesses of the photoreceptor outer segment (OS), outer nuclear layer (ONL), 
      inner nuclear layer (INL), and the retinal nerve fiber layer (RNFL) were measured 
      at 1 degrees , 3 degrees , 5 degrees , 7 degrees , and 9 degrees  from the fovea. The same measurements were made on the 
      SD-OCT images of 40 healthy subjects and used as controls. The relationships 
      between the retinal sensitivities and retinal layer thicknesses were determined. 
      RESULTS: The thicknesses of the OS and ONL and their product were significantly 
      and positively correlated with the retinal sensitivities. The thickness of the 
      INL was significantly and negatively correlated with the sensitivity. The 
      strongest correlation with the sensitivity was with the OS thickness (marginal R2 
      [mR2] = 0.525, P < 0.001), followed by the product of the OS and ONL thicknesses 
      (mR2 = 0.420, P < 0.001), ONL thickness (mR2 = 0.416, P < 0.001), and the INL 
      thickness (mR2 = 0.014, P = 0.044). The thickness of the RNFL was not correlated 
      with the sensitivity (mR2 = 0.005, P = 0.331). CONCLUSIONS: In contrast to 
      previous reports, the thickness of the OS reflected the retinal sensitivity 
      better than the product of OS and ONL.
FAU - Sayo, Akira
AU  - Sayo A
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Ueno, Shinji
AU  - Ueno S
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Kominami, Taro
AU  - Kominami T
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Okado, Satoshi
AU  - Okado S
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Inooka, Daiki
AU  - Inooka D
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Komori, Shiori
AU  - Komori S
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Terasaki, Hiroko
AU  - Terasaki H
AD  - Department of Ophthalmology, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Electroretinography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retina/diagnostic imaging/*pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Retinitis Pigmentosa/diagnostic imaging/*physiopathology
MH  - Tomography, Optical Coherence/methods
MH  - Visual Acuity/physiology
MH  - Visual Field Tests
MH  - Visual Fields/*physiology
MH  - Young Adult
EDAT- 2018/07/20 06:00
MHDA- 2019/03/19 06:00
CRDT- 2018/07/20 06:00
PHST- 2018/07/20 06:00 [entrez]
PHST- 2018/07/20 06:00 [pubmed]
PHST- 2019/03/19 06:00 [medline]
AID - 2688227 [pii]
AID - 10.1167/iovs.18-24635 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2018 Jul 2;59(8):3469-3475. doi: 
      10.1167/iovs.18-24635.