PMID- 30025408
OWN - NLM
STAT- MEDLINE
DCOM- 20190930
LR  - 20200306
IS  - 1661-7819 (Electronic)
IS  - 1661-7800 (Print)
IS  - 1661-7800 (Linking)
VI  - 114
IP  - 4
DP  - 2018
TI  - Perinatal Anemia is Associated with Neonatal and Neurodevelopmental Outcomes in 
      Infants with Moderate to Severe Perinatal Asphyxia.
PG  - 315-322
LID - 10.1159/000490369 [doi]
AB  - BACKGROUND: Perinatal anemia may cause perinatal asphyxia. Its pathophysiology 
      and neurodevelopmental effects are theoretically different from other causes of 
      perinatal asphyxia. OBJECTIVE: The study aimed to determine whether perinatal 
      anemia results in different short-term and long-term outcomes than other causes 
      of perinatal asphyxia treated with therapeutic hypothermia. METHODS: We 
      retrospectively included infants with moderate to severe hypoxic-ischemic 
      encephalopathy, born between May 2009 and October 2015. During follow-up, we 
      assessed cognitive and motor development at 2-3 years of age, using the Bayley 
      Scales of Infant and Toddler Development, third edition (BSID-III). 
      Neurodevelopmental outcome (NDO) was classified as abnormal in case of cerebral 
      palsy with Gross Motor Function Classification System >/=III and/or a BSID-III 
      composite score < 85. Outcomes of infants with perinatal anemia (initial 
      hemoglobin < 7 mmol/L) were compared to infants born with perinatal asphyxia due 
      to other causes. RESULTS: In total, 111 infants were included of whom 30 infants 
      (27%) died during the neonatal period. Infants with anemia (n = 23) had a higher 
      mortality risk, OR 3.33, 95% CI 1.27-8.72, p = 0.01. None of the surviving 
      infants with anemia (n = 12) had an abnormal NDO, in contrast to 26/69 (38%) with 
      neurodevelopmental impairments, particularly motor problems, in the non-anemic 
      group, p < 0.01. CONCLUSIONS: Perinatal anemia causing moderate to severe 
      perinatal asphyxia is associated with a higher risk for neonatal mortality. All 
      survivors with perinatal anemia, however, showed a normal NDO in contrast to 
      children who were born asphyxiated due to other causes. The underlying 
      pathophysiological mechanism for the favorable NDO in the perinatal anemia group 
      needs further elucidation.
CI  - (c) 2018 The Author(s) Published by S. Karger AG, Basel.
FAU - Kalteren, Willemien S
AU  - Kalteren WS
FAU - Ter Horst, Hendrik J
AU  - Ter Horst HJ
FAU - den Heijer, Anne E
AU  - den Heijer AE
FAU - de Vetten, Leanne
AU  - de Vetten L
FAU - Kooi, Elisabeth M W
AU  - Kooi EMW
FAU - Bos, Arend F
AU  - Bos AF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180719
PL  - Switzerland
TA  - Neonatology
JT  - Neonatology
JID - 101286577
SB  - IM
MH  - Anemia, Neonatal/mortality/*physiopathology
MH  - Asphyxia Neonatorum/mortality/*physiopathology/therapy
MH  - *Child Development
MH  - Child, Preschool
MH  - Developmental Disabilities/epidemiology/*etiology
MH  - Female
MH  - Humans
MH  - Hypothermia, Induced
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Parturition
MH  - Regression Analysis
MH  - Retrospective Studies
PMC - PMC6390452
OTO - NOTNLM
OT  - Hypoxic-ischemic encephalopathy
OT  - Mortality
OT  - Neurodevelopmental outcome
OT  - Perinatal anemia
EDAT- 2018/07/20 06:00
MHDA- 2019/10/01 06:00
PMCR- 2018/07/19
CRDT- 2018/07/20 06:00
PHST- 2018/01/31 00:00 [received]
PHST- 2018/05/24 00:00 [accepted]
PHST- 2018/07/20 06:00 [pubmed]
PHST- 2019/10/01 06:00 [medline]
PHST- 2018/07/20 06:00 [entrez]
PHST- 2018/07/19 00:00 [pmc-release]
AID - 000490369 [pii]
AID - neo-0114-0315 [pii]
AID - 10.1159/000490369 [doi]
PST - ppublish
SO  - Neonatology. 2018;114(4):315-322. doi: 10.1159/000490369. Epub 2018 Jul 19.