PMID- 30025860
OWN - NLM
STAT- MEDLINE
DCOM- 20190329
LR  - 20190329
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 388
DP  - 2018 Sep 15
TI  - Maternal High-fat Diet Programs Offspring Emotional Behavior in Adulthood.
PG  - 87-101
LID - S0306-4522(18)30489-5 [pii]
LID - 10.1016/j.neuroscience.2018.07.014 [doi]
AB  - Prenatal exposure to high-fat diet (HFD) might predispose offspring to develop 
      metabolic and mental disorders later in life. Insight into the molecular and 
      behavioral consequences of maternal HFD on offspring is sparse but may involve 
      both neuroinflammation and a dysregulated neuroendocrine stress axis. Thus, the 
      aim of this work was to: (i) investigate the influence of maternal HFD on memory, 
      anxiety and depression-like behavior in adult offspring and (ii) identify 
      possible biological biomarkers related to neuroinflammation and stress responses. 
      Seven-week-old, female Sprague-Dawley rats received a control diet or a HFD eight 
      weeks prior to conception and during gestation and lactation. We investigated the 
      phenotype of the offspring in the in elevated plus maze, forced swim test, novel 
      object recognition and open field test. Furthermore, hippocampal gene expression 
      related to neuroinflammation and the stress axis was quantitated by real-time 
      qPCR. We found that maternal HFD led to an anxiogenic offspring phenotype in the 
      elevated plus maze, independent of sex. This behavioral alteration was 
      accompanied by significantly higher mRNA levels of the hippocampal 
      pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) mRNA and 
      monocyte-chemoattractant protein-1 (MCP-1), both of which correlated with degree 
      of behavioral change. Maternal exposure to HFD increased the offspring's levels 
      of hippocampal, corticosteroid releasing hormone receptor 2 (CRHR2) and 
      kynurenine mono oxygenase (KMO) mRNA, whereas kynurenine aminotransferase I 
      (KAT1) mRNA levels were decreased. The present results suggest that 
      neuroinflammatory and stress axis pathways in the hippocampus may contribute to 
      anxiogenic effects of maternal HFD in offspring.
CI  - Copyright (c) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Winther, Gudrun
AU  - Winther G
AD  - Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus 
      University, Risskov DK-8240, Denmark. Electronic address: 
      gudrun.winther@clin.au.dk.
FAU - Elfving, Betina
AU  - Elfving B
AD  - Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus 
      University, Risskov DK-8240, Denmark. Electronic address: 
      betina.elfving@clin.au.dk.
FAU - Muller, Heidi Kaastrup
AU  - Muller HK
AD  - Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus 
      University, Risskov DK-8240, Denmark. Electronic address: 
      heidi.muller@clin.au.dk.
FAU - Lund, Sten
AU  - Lund S
AD  - Department of Endocrinology and Internal Medicine Medical Research Laboratory, 
      Aarhus University Hospital, DK-8000, Denmark. Electronic address: 
      sten.lund@clin.au.dk.
FAU - Wegener, Gregers
AU  - Wegener G
AD  - Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus 
      University, Risskov DK-8240, Denmark; Department of Clinical Medicine, AUGUST 
      Centre, Aarhus University, Risskov DK-8240, Denmark; Center of Excellence for 
      Pharmaceutical Sciences, North-West University (Potchefstroom Campus), Hoffman 
      Street, Potchefstroom 2520, South Africa. Electronic address: wegener@clin.au.dk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180717
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Cytokines)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - *Anxiety/metabolism
MH  - *Behavior, Animal/physiology
MH  - Cytokines/metabolism
MH  - Diet, High-Fat/*adverse effects
MH  - *Emotions/physiology
MH  - Female
MH  - Gene Expression Regulation
MH  - Hippocampus/metabolism
MH  - Male
MH  - *Maternal Nutritional Physiological Phenomena
MH  - Neuroimmunomodulation/physiology
MH  - RNA, Messenger/metabolism
MH  - Random Allocation
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - anxiety
OT  - depression
OT  - maternal obesity
OT  - pregnancy
OT  - prenatal programing
EDAT- 2018/07/22 06:00
MHDA- 2019/03/30 06:00
CRDT- 2018/07/21 06:00
PHST- 2018/01/31 00:00 [received]
PHST- 2018/07/01 00:00 [revised]
PHST- 2018/07/06 00:00 [accepted]
PHST- 2018/07/22 06:00 [pubmed]
PHST- 2019/03/30 06:00 [medline]
PHST- 2018/07/21 06:00 [entrez]
AID - S0306-4522(18)30489-5 [pii]
AID - 10.1016/j.neuroscience.2018.07.014 [doi]
PST - ppublish
SO  - Neuroscience. 2018 Sep 15;388:87-101. doi: 10.1016/j.neuroscience.2018.07.014. 
      Epub 2018 Jul 17.