PMID- 30026088
OWN - NLM
STAT- MEDLINE
DCOM- 20181024
LR  - 20181024
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 120
DP  - 2018 Oct
TI  - Antioxidant, anti-inflammatory and synergistic anti-hyperglycemic effects of 
      Malaysian propolis and metformin in streptozotocin-induced diabetic rats.
PG  - 305-320
LID - S0278-6915(18)30473-3 [pii]
LID - 10.1016/j.fct.2018.07.028 [doi]
AB  - Diabetes mellitus is characterized by hyperglycemia which causes oxidative 
      stress. Propolis has been reported to have antihyperglycemic and antioxidant 
      potentials. The present study therefore examined the anti-hyperglycemic, 
      antioxidant and anti-inflammatory activities of Malaysian propolis (MP) using 
      streptozotocin-induced diabetic rats. Ethanol extract of MP showed in vitro 
      antioxidant (DPPH, FRAP and H2O2 radical scavenging) and alpha-glucosidase inhibition 
      activities. Male Sprague Dawley rats were either treated with distilled water 
      (normal control and diabetic control), MP (300 mg/kg b. w.), metformin (Met) 
      (300 mg/kg b. w.) or both. After four weeks, fasting blood glucose decreased, 
      while body weight change and serum insulin level increased significantly in MP, 
      Met and MP + Met treated diabetic groups compared to diabetic control (DC) group. 
      Furthermore, pancreatic antioxidant enzymes, total antioxidant capacity, 
      interleukin (IL)-10 and proliferating cell nuclear antigen increased, while 
      malondialdehyde, nuclear factor-kappa B (p65), tumor necrosis factor alpha, IL-1beta 
      and cleaved caspase-3 decreased significantly in the treated diabetic groups 
      compared to DC group. Histopathology of the pancreas showed increased islet area 
      and number of beta cells in the treated groups, compared to DC group, with 
      D + MP + Met group comparable to normal control. We conclude that MP has 
      anti-hyperglycemic, antioxidant, anti-inflammatory and antiapoptotic potentials, 
      and exhibits synergistic effect with metformin.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Nna, Victor Udo
AU  - Nna VU
AD  - Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 
      16150, Kelantan, Malaysia; Department of Physiology, Faculty of Basic Medical 
      Sciences, College of Medical Sciences, University of Calabar, P.M.B. 1115, 
      Calabar, Cross River State, Nigeria.
FAU - Abu Bakar, Ainul Bahiyah
AU  - Abu Bakar AB
AD  - Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 
      16150, Kelantan, Malaysia.
FAU - Md Lazin, Md Rizman Md Lazim
AU  - Md Lazin MRML
AD  - Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 
      16150, Kelantan, Malaysia.
FAU - Mohamed, Mahaneem
AU  - Mohamed M
AD  - Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 
      16150, Kelantan, Malaysia; Unit of Integrative Medicine, School of Medical 
      Sciences, Universiti Sains Malaysia, 16150, Kelantan, Malaysia. Electronic 
      address: mahaneem@usm.my.
LA  - eng
PT  - Journal Article
DEP - 20180717
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycoside Hydrolase Inhibitors)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-1)
RN  - 0 (NF-kappa B)
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 5W494URQ81 (Streptozocin)
RN  - 9009-62-5 (Propolis)
RN  - 9100L32L2N (Metformin)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Antioxidants/*therapeutic use
MH  - Blood Glucose/metabolism
MH  - Caspase 3/metabolism
MH  - Diabetes Mellitus, Experimental/*drug therapy/physiopathology
MH  - Drug Synergism
MH  - Glycoside Hydrolase Inhibitors/pharmacology
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Insulin/blood
MH  - Interleukin-1/metabolism
MH  - Islets of Langerhans/enzymology/physiopathology
MH  - Malaysia
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Metformin/*therapeutic use
MH  - NF-kappa B/metabolism
MH  - Proliferating Cell Nuclear Antigen/metabolism
MH  - *Propolis
MH  - Rats, Sprague-Dawley
MH  - Streptozocin
OTO - NOTNLM
OT  - Antioxidant
OT  - Diabetes
OT  - Inflammation
OT  - Malaysian propolis
OT  - Metformin
EDAT- 2018/07/22 06:00
MHDA- 2018/10/26 06:00
CRDT- 2018/07/21 06:00
PHST- 2018/05/30 00:00 [received]
PHST- 2018/06/23 00:00 [revised]
PHST- 2018/07/15 00:00 [accepted]
PHST- 2018/07/22 06:00 [pubmed]
PHST- 2018/10/26 06:00 [medline]
PHST- 2018/07/21 06:00 [entrez]
AID - S0278-6915(18)30473-3 [pii]
AID - 10.1016/j.fct.2018.07.028 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2018 Oct;120:305-320. doi: 10.1016/j.fct.2018.07.028. Epub 
      2018 Jul 17.