PMID- 30026692
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 10
DP  - 2018
TI  - The Moderating Role of COMT and BDNF Polymorphisms on Transfer Effects Following 
      Multi- and Single-Domain Cognitive Training Among Community-Dwelling Shanghainese 
      Older Adults.
PG  - 198
LID - 10.3389/fnagi.2018.00198 [doi]
LID - 198
AB  - Given the increase in research suggesting benefit following cognitive training in 
      older adults, researchers have started to investigate the potential moderating 
      role of genetic polymorphisms on transfer effects. The objective of this study 
      was to evaluate the moderating effect of catechol-O-methyltransferase (COMT) and 
      brain-derived neurotrophic factor (BDNF) polymorphisms on transfer effects 
      following a single-domain or multi-domain training intervention in healthy 
      community-dwelling older adults. A total of 104 men and women living in Shanghai 
      were randomized to a multi-domain or a single-domain cognitive training (SDCT) 
      group. COMT rs4818 SNP and the BDNF rs6265 SNP were analyzed from blood. At 
      pre-intervention, post-intervention and at 6-month follow-up, participants 
      completed the Repeatable Battery for the Assessment of Neuropsychological Status 
      (RBANS), the Color-Word Stroop Test (CWST), the Trails Making Test (TMT) and the 
      Visual Reasoning Test (VRT). COMT was found to moderate immediate memory transfer 
      effects following single-domain training only, with G/- carriers displaying 
      greater benefits than C/C carriers. BDNF was found to moderate attention and 
      inhibition independent of the training, with Met/- carriers displaying better 
      performance than Val/Val carriers. Overall, individualizing training methods with 
      full consideration of genetic polymorphisms may promote the maximization of 
      cognitive training benefits.
FAU - Jiang, Jiangling
AU  - Jiang J
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center 
      (SMHC), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Fiocco, Alexandra J
AU  - Fiocco AJ
AD  - Department of Psychology, Institute for Stress and Wellbeing Research, Ryerson 
      University, Toronto, ON, Canada.
FAU - Cao, Xinyi
AU  - Cao X
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center 
      (SMHC), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Jiang, Lijuan
AU  - Jiang L
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center 
      (SMHC), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Feng, Wei
AU  - Feng W
AD  - Department of Psychiatry, Tongji Hospital of Tongji University, Shanghai, China.
FAU - Shen, Yuan
AU  - Shen Y
AD  - Department of Psychiatry, Shanghai Tenth People's Hospital of Tongji University, 
      Shanghai, China.
FAU - Li, Ting
AU  - Li T
AD  - Shanghai Changning Mental Health Center, Shanghai, China.
FAU - Li, Chunbo
AU  - Li C
AD  - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center 
      (SMHC), Shanghai Jiao Tong University School of Medicine, Shanghai, China.
AD  - Brain Science and Technology Research Center, Shanghai Jiao Tong University, 
      Shanghai, China.
AD  - Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), 
      Chinese Academy of Sciences, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20180705
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC6041383
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - catechol-O-methyltransferase
OT  - cognitive training
OT  - single nucleotide polymorphism
OT  - successful aging
EDAT- 2018/07/22 06:00
MHDA- 2018/07/22 06:01
PMCR- 2018/01/01
CRDT- 2018/07/21 06:00
PHST- 2018/03/24 00:00 [received]
PHST- 2018/06/11 00:00 [accepted]
PHST- 2018/07/21 06:00 [entrez]
PHST- 2018/07/22 06:00 [pubmed]
PHST- 2018/07/22 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2018.00198 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2018 Jul 5;10:198. doi: 10.3389/fnagi.2018.00198. 
      eCollection 2018.