PMID- 3002957
OWN - NLM
STAT- MEDLINE
DCOM- 19860305
LR  - 20190722
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 72
IP  - 1
DP  - 1986 Jan
TI  - Mothers of children with Down syndrome have higher herpes simplex virus type 2 
      (HSV-2) antibody levels.
PG  - 9-14
AB  - The antibody response to herpes simplex virus (HSV) was studied in 53 mothers of 
      children with Down syndrome (Ds) and compared with that in 154 controls, using 
      sera sampled during pregnancy or at delivery. Conventional analysis of HSV 
      complement fixing antibodies showed the same frequency of positivity for the two 
      groups (70%). When the levels of IgG antibodies to an HSV-1 and an HSV-2 antigen 
      preparation were determined by an enzyme-linked immunosorbent assay (ELISA) 
      technique, it was found that the Ds and control mothers had similar levels of IgG 
      antibodies to HSV-1, whereas the level of IgG antibodies to HSV-2 was 
      significantly (P less than 0.001) higher in Ds mothers. The ratio of HSV-2 to 
      HSV-1 ELISA IgG was calculated for each mother and the distribution of these 
      ratios also differed significantly between the control and Ds mothers. The 
      differences found were not due to differences in age distribution in the control 
      and Ds groups. For comparison a third procedure, measurement of thymidine kinase 
      blocking antibody (TK ab), was used. With this procedure the mothers were divided 
      into groups estimated to be positive for HSV-1, HSV-2, or both. Statistical 
      analyses showed a good correlation between the type found in TK ab analyses and 
      the ratio found in the ELISA HSV test. The results clearly demonstrated an 
      overrepresentation of HSV-2 antibody positivity among Ds mothers, though not of 
      sufficient magnitude to imply that HSV-2 can be the major cause of Ds. It is 
      discussed whether HSV-2 might be related to the recently increased birthrate of 
      children with Ds among young mothers in Sweden or to localized geographical 
      clustering of Ds births, or whether the increased HSV-2 antibody positivity 
      merely indicates that factors following the same epidemiological pattern are 
      involved in the aetiology of Ds.
FAU - Anneren, G
AU  - Anneren G
FAU - Gronowitz, J S
AU  - Gronowitz JS
FAU - Kallander, C F
AU  - Kallander CF
FAU - Sundqvist, V A
AU  - Sundqvist VA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Viral/*analysis
MH  - Down Syndrome/*etiology/microbiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Herpes Simplex/genetics
MH  - Humans
MH  - Maternal Age
MH  - *Mothers
MH  - *Nondisjunction, Genetic
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/genetics
MH  - Simplexvirus/*immunology
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1007/BF00278809 [doi]
PST - ppublish
SO  - Hum Genet. 1986 Jan;72(1):9-14. doi: 10.1007/BF00278809.