PMID- 30030575
OWN - NLM
STAT- MEDLINE
DCOM- 20190812
LR  - 20190812
IS  - 1433-0407 (Electronic)
IS  - 0028-2804 (Linking)
VI  - 89
IP  - 8
DP  - 2018 Aug
TI  - [MRI alterations in immunomodulation].
PG  - 945-957
LID - 10.1007/s00115-018-0565-6 [doi]
AB  - In this review article, typical imaging findings of diseases elicited by 
      immunomodulatory drugs are presented. Progressive multifocal leucoencephalopathy 
      (PML), a subacute infection due to reactivation of the JC virus, has a typical 
      magnetic resonance imaging (MRI) pattern, which must be considered in the 
      framework of immunomodulatory multiple sclerosis (MS) treatment with natalizumab, 
      fingolimod, rituximab and fumarate and also in lymphoproliferative diseases or 
      other forms of immunosuppression. Restoration of the immune system may result in 
      an overlapping and overwhelming immune response in terms of an immune 
      reconstitution inflammatory syndrome (IRIS). Further conditions with typical MRI 
      patterns comprise methotrexate-associated leucoencephalopathy and posterior 
      reversible encephalopathy syndrome (PRES). In immunotherapy with activation of 
      T‑lymphocytes, attention should always be paid to the fact that the T‑lymphocytes 
      activated by different processes not only target the diseased tissue but also 
      normal brain tissue.
FAU - Guggenberger, K
AU  - Guggenberger K
FAU - Urbach, H
AU  - Urbach H
AUID- ORCID: 0000-0001-7264-4807
AD  - Klinik fur Neuroradiologie, Universitatsklinikum Freiburg, Medizinische Fakultat, 
      Albert-Ludwigs-Universitat Freiburg, Freiburg, Deutschland. 
      horst.urbach@uniklinik-freiburg.de.
LA  - ger
PT  - Journal Article
PT  - Review
TT  - MRT-Veranderungen bei Immunmodulation.
PL  - Germany
TA  - Nervenarzt
JT  - Der Nervenarzt
JID - 0400773
RN  - 0 (Immunologic Factors)
MH  - Brain/diagnostic imaging/drug effects
MH  - Diagnosis, Differential
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/diagnosis
MH  - *Immunologic Factors/adverse effects/pharmacology/therapeutic use
MH  - *Immunomodulation
MH  - *Leukoencephalopathy, Progressive Multifocal/diagnostic imaging
MH  - Multiple Sclerosis/drug therapy
MH  - *Posterior Leukoencephalopathy Syndrome/diagnostic imaging
OTO - NOTNLM
OT  - Hypophysitis
OT  - Inflammatory immune reconstitution syndrome
OT  - Organ transplantation
OT  - Progressive multifocal leucencephalopathy
OT  - Stem cell transplantation
EDAT- 2018/07/22 06:00
MHDA- 2019/08/14 06:00
CRDT- 2018/07/22 06:00
PHST- 2018/07/22 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2018/07/22 06:00 [entrez]
AID - 10.1007/s00115-018-0565-6 [pii]
AID - 10.1007/s00115-018-0565-6 [doi]
PST - ppublish
SO  - Nervenarzt. 2018 Aug;89(8):945-957. doi: 10.1007/s00115-018-0565-6.