PMID- 30030585 OWN - NLM STAT- MEDLINE DCOM- 20190128 LR - 20210715 IS - 1433-2965 (Electronic) IS - 0937-941X (Linking) VI - 29 IP - 11 DP - 2018 Nov TI - Assessment using serum insulin-like growth factor-I and bone mineral density is useful for detecting prevalent vertebral fractures in patients with type 2 diabetes mellitus. PG - 2527-2535 LID - 10.1007/s00198-018-4638-y [doi] AB - Bone mineral density (BMD) is less useful for evaluating fracture risk in type 2 diabetes. This study showed for the first time that combined evaluation by serum insulin-like growth factor-I and BMD is useful to assess the risk of vertebral fracture in postmenopausal women and men with type 2 diabetes. INTRODUCTION: BMD is less useful for evaluating fracture risk in type 2 diabetes mellitus (T2DM). We aimed to examine the usefulness of combined evaluation by BMD and serum insulin-like growth factor-I (IGF-I) to assess the risk of vertebral fracture (VF) in T2DM. METHODS: In this cross-sectional study, 412 postmenopausal women and 582 men with T2DM, whose BMD, bone turnover markers, and serum IGF-I were measured, were enrolled. The association of BMD alone, serum IGF-I alone, and combined assessment by BMD and IGF-I with the presence of VF was examined. RESULTS: Multiple logistic regression analyses showed that IGF-I as well as BMD T-score at lumbar (L) and femoral neck (FN) were significantly associated with VF except for IGF-I in men, respectively. Receiver operating characteristic curves showed that the cutoff values of IGF-I, L T-score and FN T-score were 127 ng/mL, - 1.78, and - 2.02 in postmenopausal women and 127 ng/mL, - 1.67, and - 1.24 in men. Based on the cutoff vales, the subjects were divided into four categories. The category of lower IGF-I and lower T-scores had a significant increased risk of VF compared to higher IGF-I and higher T-scores both in postmenopausal women and in men. The sensitivity and specificity of the combined assessment to detect VF were better compared to using BMD alone or IGF-I alone. CONCLUSIONS: This is the first study to show that in addition to BMD measurement, the assessment using serum IGF-I is useful to estimate the prevalence of VF in patients with T2DM. FAU - Kanazawa, I AU - Kanazawa I AUID- ORCID: 0000-0001-9001-5609 AD - Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, 693-8501, Japan. ippei.k@med.shimane-u.ac.jp. FAU - Notsu, M AU - Notsu M AD - Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, 693-8501, Japan. FAU - Miyake, H AU - Miyake H AD - Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, 693-8501, Japan. FAU - Tanaka, K AU - Tanaka K AD - Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, 693-8501, Japan. FAU - Sugimoto, T AU - Sugimoto T AD - Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, 693-8501, Japan. LA - eng PT - Journal Article DEP - 20180720 PL - England TA - Osteoporos Int JT - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JID - 9100105 RN - 0 (Biomarkers) RN - 0 (IGF1 protein, human) RN - 67763-96-6 (Insulin-Like Growth Factor I) SB - IM MH - Aged MH - Aged, 80 and over MH - Biomarkers/blood MH - Bone Density/*physiology MH - Bone Remodeling/physiology MH - Diabetes Mellitus, Type 2/*complications/physiopathology MH - Female MH - Femur Neck/physiopathology MH - Humans MH - Insulin-Like Growth Factor I/*analysis MH - Lumbar Vertebrae/diagnostic imaging/physiopathology MH - Male MH - Middle Aged MH - Osteoporotic Fractures/*diagnosis/etiology/physiopathology MH - Radiography MH - Spinal Fractures/*diagnosis/etiology/physiopathology MH - Thoracic Vertebrae/diagnostic imaging OTO - NOTNLM OT - Bone mineral density OT - Insulin-like growth factor-I OT - Type 2 diabetes mellitus OT - Vertebral fracture EDAT- 2018/07/22 06:00 MHDA- 2019/01/29 06:00 CRDT- 2018/07/22 06:00 PHST- 2018/03/27 00:00 [received] PHST- 2018/07/09 00:00 [accepted] PHST- 2018/07/22 06:00 [pubmed] PHST- 2019/01/29 06:00 [medline] PHST- 2018/07/22 06:00 [entrez] AID - 10.1007/s00198-018-4638-y [pii] AID - 10.1007/s00198-018-4638-y [doi] PST - ppublish SO - Osteoporos Int. 2018 Nov;29(11):2527-2535. doi: 10.1007/s00198-018-4638-y. Epub 2018 Jul 20.