PMID- 30031008
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 175
DP  - 2018 Oct
TI  - Stem cell rejuvenation and the role of autophagy in age retardation by caloric 
      restriction: An update.
PG  - 46-54
LID - S0047-6374(18)30029-0 [pii]
LID - 10.1016/j.mad.2018.07.005 [doi]
AB  - Stem cells being pluripotent in nature can differentiate into a wide array of 
      specific cells and asymmetrically divide to produce new ones but may undergo 
      aging by themselves. Aging has both quantitative and qualitative effects on stem 
      cells, and could eventually restrain them from replenishing into progenitor 
      cells. Reactive oxygen species (ROS) accumulated in the aging cells could not 
      only block the cell cycle but also affect autophagy by damaging the mitochondria. 
      Autophagy could eliminate redundant production of ROS in aging stem cells and 
      helps to maintain the proliferation capacity by restraining the expression of 
      p16(INK4a). Current studies showed that improving autophagy could restore the 
      regenerative ability of aging stem cells. Therefore, it is important for an 
      organism to maintain the appropriate autophagy. Caloric restriction (CR) was 
      shown to retard the stem cell aging by a certain basic level of autophagy, 
      suggesting that CR was an effective way to extend longevity in mammals. However, 
      little is known about the underlying mechanisms. In this review, we tried to 
      explore the molecular mechanisms on how CR induces appropriate autophagy to 
      restore aging stem cell regenerative ability.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Bi, Shanrong
AU  - Bi S
AD  - The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Wang, Hanyu
AU  - Wang H
AD  - The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Kuang, Weihong
AU  - Kuang W
AD  - The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 
      Guangzhou, China. Electronic address: kwh@gzucm.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180718
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Age Factors
MH  - Aging/*metabolism/pathology
MH  - Animals
MH  - *Autophagy
MH  - *Caloric Restriction
MH  - *Cell Proliferation
MH  - *Cell Self Renewal
MH  - *Energy Metabolism
MH  - Humans
MH  - Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
MH  - Rejuvenation
MH  - Signal Transduction
MH  - Stem Cells/*metabolism/pathology
OTO - NOTNLM
OT  - Age retardation
OT  - Autophagy
OT  - Caloric restriction
OT  - ROS
OT  - Stem cell aging
EDAT- 2018/07/22 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/07/22 06:00
PHST- 2018/02/10 00:00 [received]
PHST- 2018/07/17 00:00 [revised]
PHST- 2018/07/17 00:00 [accepted]
PHST- 2018/07/22 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/07/22 06:00 [entrez]
AID - S0047-6374(18)30029-0 [pii]
AID - 10.1016/j.mad.2018.07.005 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2018 Oct;175:46-54. doi: 10.1016/j.mad.2018.07.005. Epub 2018 
      Jul 18.