PMID- 30031155
OWN - NLM
STAT- MEDLINE
DCOM- 20191021
LR  - 20220408
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Linking)
VI  - 286
DP  - 2018 Sep 28
TI  - Graphene-based nanomaterials and their potentials in advanced drug delivery and 
      cancer therapy.
PG  - 64-73
LID - S0168-3659(18)30428-0 [pii]
LID - 10.1016/j.jconrel.2018.07.034 [doi]
AB  - The continuing increase of cancer morbidity and death rate requires efficient 
      therapeutic strategies. The traditional chemotherapy usually fails to treat 
      cancer or prolong survival rate due to its toxicity to normal cells, side effects 
      and lack of targeting capacity. In recent years, nanomaterials have shown great 
      potentials to treat various cancers efficiently. Graphene-based nanomaterials, 
      especially graphene oxide (GO) and reduced GO (rGO), have arisen as promising 
      candidates for cancer therapy. Due to their unique physicochemical and optical 
      properties including the extremely large surface area, modifiable active groups, 
      great biocompatibility and strong photothermal effect, they can act either as 
      tunable carriers or active agents for advanced chemotherapeutics delivery and 
      cancer therapy. Therefore, combing the photothermal therapy, targeted drug 
      delivery and chemotherapy would have great potentials for efficient cancer 
      therapy. Herein, the comprehensive understandings of the physicochemical 
      properties and various anti-cancer applications of GO and rGO as drug delivery 
      systems or photothermal agents are described. Also, the concerns in using GO and 
      rGO, such as the nano-protein interaction, and possible solutions are discussed.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Liu, Jinzhao
AU  - Liu J
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, 
      China.
FAU - Dong, Jia
AU  - Dong J
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, 
      China.
FAU - Zhang, Ting
AU  - Zhang T
AD  - Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, 
      China.
FAU - Peng, Qiang
AU  - Peng Q
AD  - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral 
      Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, 
      China. Electronic address: qiangpengzz@scu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180718
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (graphene oxide)
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/administration & dosage/therapeutic use
MH  - Drug Carriers/chemistry/therapeutic use
MH  - Drug Delivery Systems/*methods
MH  - Graphite/*chemistry/*therapeutic use
MH  - Humans
MH  - Hyperthermia, Induced/methods
MH  - Nanomedicine/methods
MH  - Nanostructures/*chemistry/*therapeutic use
MH  - Neoplasms/drug therapy/*therapy
MH  - Phototherapy/methods
OTO - NOTNLM
OT  - Carbon
OT  - Covalent bonding
OT  - Near-infrared light
OT  - Oncology
OT  - Physisorption
OT  - Toxicity
EDAT- 2018/07/22 06:00
MHDA- 2019/10/23 06:00
CRDT- 2018/07/22 06:00
PHST- 2018/05/20 00:00 [received]
PHST- 2018/07/16 00:00 [revised]
PHST- 2018/07/17 00:00 [accepted]
PHST- 2018/07/22 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
PHST- 2018/07/22 06:00 [entrez]
AID - S0168-3659(18)30428-0 [pii]
AID - 10.1016/j.jconrel.2018.07.034 [doi]
PST - ppublish
SO  - J Control Release. 2018 Sep 28;286:64-73. doi: 10.1016/j.jconrel.2018.07.034. 
      Epub 2018 Jul 18.