PMID- 30031945
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20190114
IS  - 1532-9488 (Electronic)
IS  - 1043-0679 (Linking)
VI  - 30
IP  - 3
DP  - 2018 Autumn
TI  - Surgical Treatment of Pulmonary Complications in Behcet's Syndrome.
PG  - 369-378
LID - S1043-0679(18)30118-7 [pii]
LID - 10.1053/j.semtcvs.2018.07.008 [doi]
AB  - We described disease characteristics, management and outcome of a group of 
      Behcet's syndrome (BS) patients who underwent pulmonary lobectomy, segmentectomy 
      or various pleura interventions for complications due to pulmonary artery or 
      descending aorta involvement. There were 9 patients with BS (8 M/1 F; mean age: 
      24.8 +/- 7.5 and mean disease duration: 4.3 +/- 3.8 years) who underwent lung surgery 
      from 2000 to 2017. Their medical files including operation details and 
      radiological and pathological studies were reviewed retrospectively. Lobectomy 
      was done in 6 patients, decortications and pleura interventions in the remaining 
      3. The reason for the surgical procedures were giant pulmonary arterial aneurysms 
      refractory to the medical treatment (n = 4), pneumothorax due to large cavities 
      (n = 2), pleural effusions refractory to the medical treatment (n = 1), a 
      bronchopleural fistula after embolization (n = 1) and bronchiectasis (n = 1). All 
      patients received medical treatment with cyclophosphamide and corticosteroids 
      before the surgical interventions. The histological examination in patients with 
      pseudo-aneurysms showed destruction of medial elastic fibers, inflammatory cell 
      infiltration of adventitial tissues and penetration into the adjacent bronchi 
      with adherent thrombi. Two patients died: one due to Budd-Chiari syndrome 1 year 
      after the surgery, another because of a massive hemoptysis 3 months after 
      lobectomy. The remaining 7 patients are still alive with a median follow-up of 8 
      years (inter-quartile range [IQR]: 4-11). Lobectomies in BS patients with giant 
      pulmonary aneurysms refractory to medical treatment can be done with favorable 
      outcome. Also, complications such as large cavities causing pneumothorax, 
      refractory pleural effusions, bronchiectasis, and embolization complications can 
      be managed effectively with surgical interventions.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Tuzun, Hasan
AU  - Tuzun H
AD  - Department of Cardiovascular Surgery, Cerrahpasa Medical Faculty, University of 
      Istanbul, Istanbul, Turkey. Electronic address: hasantuzun@superonline.com.
FAU - Seyahi, Emire
AU  - Seyahi E
AD  - Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, 
      University of Istanbul, Istanbul, Turkey.
FAU - Guzelant, Gul
AU  - Guzelant G
AD  - Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, 
      University of Istanbul, Istanbul, Turkey.
FAU - Oz, Buge
AU  - Oz B
AD  - Department of Pathology, Cerrahpasa Medical Faculty, University of Istanbul, 
      Istanbul, Turkey.
FAU - Batur, Sebnem
AU  - Batur S
AD  - Department of Pathology, Cerrahpasa Medical Faculty, University of Istanbul, 
      Istanbul, Turkey.
FAU - Demirhan, Ozkan
AU  - Demirhan O
AD  - Department of Cardiothoracic Surgery, Istanbul Bilim University, Turkey.
FAU - Hamuryudan, Vedat
AU  - Hamuryudan V
AD  - Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, 
      University of Istanbul, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20180719
PL  - United States
TA  - Semin Thorac Cardiovasc Surg
JT  - Seminars in thoracic and cardiovascular surgery
JID - 8917640
RN  - 0 (Immunosuppressive Agents)
SB  - IM
CIN - Semin Thorac Cardiovasc Surg. 2018 Autumn;30(3):379-380. PMID: 30236452
MH  - Adolescent
MH  - Adult
MH  - Aneurysm/diagnosis/etiology/mortality/*surgery
MH  - Behcet Syndrome/*complications/diagnosis/drug therapy/mortality
MH  - Biopsy
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Lung Diseases/diagnosis/etiology/mortality/*surgery
MH  - Male
MH  - *Pneumonectomy/adverse effects/mortality
MH  - Pulmonary Artery/pathology/*surgery
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Time Factors
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Behcet's syndrome
OT  - Pulmonary
OT  - surgical treatments
EDAT- 2018/07/23 06:00
MHDA- 2019/01/15 06:00
CRDT- 2018/07/23 06:00
PHST- 2018/05/12 00:00 [received]
PHST- 2018/07/11 00:00 [accepted]
PHST- 2018/07/23 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
PHST- 2018/07/23 06:00 [entrez]
AID - S1043-0679(18)30118-7 [pii]
AID - 10.1053/j.semtcvs.2018.07.008 [doi]
PST - ppublish
SO  - Semin Thorac Cardiovasc Surg. 2018 Autumn;30(3):369-378. doi: 
      10.1053/j.semtcvs.2018.07.008. Epub 2018 Jul 19.