PMID- 30032068
OWN - NLM
STAT- MEDLINE
DCOM- 20190221
LR  - 20200307
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 267
DP  - 2018 Sep
TI  - Test-retest reliability of short-interval intracortical inhibition and 
      intracortical facilitation in patients with schizophrenia.
PG  - 575-581
LID - S0165-1781(17)32069-3 [pii]
LID - 10.1016/j.psychres.2018.06.014 [doi]
AB  - Impaired short-interval intracortical inhibition (SICI) elicited by paired-pulse 
      TMS (ppTMS) has emerged as one of the most consistent TMS findings in patients 
      with schizophrenia. Reduction of SICI has been reproducibly found, suggesting 
      that SICI may be a new biomarker indexing the inhibitory dysfunction in 
      schizophrenia. This study evaluated whether SICI has the test-retest reliability 
      suitable for clinical trial and research applications. SICIs, intracortical 
      facilitation (ICF), and other ppTMS effects were obtained using inter-stimulus 
      intervals (ISIs) from 1 to 500 ms, on 2 occasions about 3-4 weeks apart in 
      patients with schizophrenia and healthy individuals. Acceptable test-retest 
      reliabilities were found for SICI (at 1 and 3 ms ISIs) in both patients and 
      controls (all intraclass correlation coefficients r > 0.6). However, test-retest 
      reliability in longer ISIs and in ICF were modest or poor. To our knowledge, this 
      is the first study demonstrated the acceptable reliability of SICI measure in 
      patients with schizophrenia. The data support SICI as a reliable biomarker for 
      schizophrenia.
CI  - Published by Elsevier B.V.
FAU - Du, Xiaoming
AU  - Du X
AD  - Maryland Psychiatric Research Center, Department of Psychiatry, University of 
      Maryland School of Medicine, P.O. Box 21247, Baltimore, MD 21228, USA. Electronic 
      address: xdu@mprc.umaryland.edu.
FAU - Hong, L Elliot
AU  - Hong LE
AD  - Maryland Psychiatric Research Center, Department of Psychiatry, University of 
      Maryland School of Medicine, P.O. Box 21247, Baltimore, MD 21228, USA.
LA  - eng
GR  - R01 MH116948/MH/NIMH NIH HHS/United States
GR  - U01 MH108148/MH/NIMH NIH HHS/United States
GR  - T32 MH067533/MH/NIMH NIH HHS/United States
GR  - P50 MH103222/MH/NIMH NIH HHS/United States
GR  - R01 MH112180/MH/NIMH NIH HHS/United States
GR  - R01 MH085646/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180619
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adult
MH  - Electromyography/methods/psychology/standards
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - Neural Inhibition/*physiology
MH  - Reproducibility of Results
MH  - Schizophrenia/physiopathology/*therapy
MH  - *Schizophrenic Psychology
MH  - Transcranial Magnetic Stimulation/*methods/standards
MH  - Young Adult
PMC - PMC6131061
MID - NIHMS1500579
OTO - NOTNLM
OT  - Intersession
OT  - Reliability
OT  - SICI
OT  - Schizophrenia
OT  - TMS
EDAT- 2018/07/23 06:00
MHDA- 2019/02/23 06:00
PMCR- 2019/09/01
CRDT- 2018/07/23 06:00
PHST- 2017/11/09 00:00 [received]
PHST- 2018/05/29 00:00 [revised]
PHST- 2018/06/07 00:00 [accepted]
PHST- 2018/07/23 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2018/07/23 06:00 [entrez]
PHST- 2019/09/01 00:00 [pmc-release]
AID - S0165-1781(17)32069-3 [pii]
AID - 10.1016/j.psychres.2018.06.014 [doi]
PST - ppublish
SO  - Psychiatry Res. 2018 Sep;267:575-581. doi: 10.1016/j.psychres.2018.06.014. Epub 
      2018 Jun 19.