PMID- 30032523
OWN - NLM
STAT- MEDLINE
DCOM- 20181030
LR  - 20181030
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 98
IP  - 27
DP  - 2018 Jul 17
TI  - [Correlation of CT small airway measurement with clinical and inflammation 
      factors in asthma patients].
PG  - 2184-2188
LID - 10.3760/cma.j.issn.0376-2491.2018.27.012 [doi]
AB  - Objective: To evaluate the correlation of CT small airway measurement with 
      clinical and inflammatory factors in asthma patients. Methods: From November 2014 
      to December 2015, a total of 20 patients with asthma were recruited in outpatient 
      department of Peking University Third Hospital. All underwent asthma control test 
      (ACT), CT and pulmonary function test. Serum leptin, immunoglobulin E(IgE) and 
      transforming growth factor-beta1(TGF-beta1), induced sputum eosinophil percentage(Eos%) 
      and matrix metalloproteinase(MMP-9) results were collected.Using GE airway 
      analysis software and adjusted by body surface area, luminal 
      diameter(LD(adjusted)), luminal area(Ai(adjusted)), wall thickness(WT(adjusted)) 
      and wall area%(WA%)at the end of 6th generation airway were recorded. Results: In 
      asthma patients with smoking history, both LD(adjusted) and Ai(adjusted) were 
      significantly lower than patients without smoking history(LD(adjutsed) 
      (1.19+/-0.14)vs(1.34+/-0.11) mm, Ai(adjusted) (1.13+/-0.32) vs (1.43+/-0.24) mm(2,) 
      t=-2.459, -2.267, all P<0.05); in asthma patients with induced sputum Eos%>/=3%, 
      both LD(adjusted) and Ai(adjusted) were significantly lower but WA% significantly 
      higher than patients with induced sputum Eos%<3% (LD(adjutsed) (1.26+/-0.05) vs 
      (1.44+/-0.09) mm, Ai(adjusted)(1.27+/-0.11) vs (1.66+/-0.17) mm(2,) WA%(83.96%+/-1.26%) 
      vs (81.20%+/-2.26%), t=-3.935, -4.492, 2.448, all P<0.05). LD(adjutsed) and 
      Ai(adjusted) had negative correlation with course of disease and induced sputum 
      Eos%(LD(adjutsed) r=-0.512, -0.841, Ai(adjusted) r=-0.489, -0.841, all P<0.05), 
      and positive correlation with FEV(1)/FVC and serum leptin(LD(adjutsed) r=0.669, 
      0.533, Ai(adjusted) r=0.681, 0.552, all P<0.05). Ai(adjusted) also showed 
      positive correlation with FEV(1)%(r=0.452, P<0.05). WT(adjusted) and WA% were 
      significantly negative correlated with FEV(1)/FVC and FEV(1)%(WT(adjusted) 
      r=-0.621, -0.483, WA% r=-0.729, -0.548, all P<0.05). WA% also showed positive 
      correlation with serum IgE and induced sputum MMP-9(r=0.509, 0.636, all P<0.05). 
      CT airway indexes showed no significantly correlation with age, ACT scores and 
      serum TGF-beta1. Conclusions: CT airway indexes are found partially associated with 
      course of disease, smoking history, serum leptin and IgE, induced sputum Eos% and 
      MMP-9. CT airway indexes show correlation with FEV(1)/FVC and FEV(1)%.
FAU - Li, M J
AU  - Li MJ
AD  - Department of Radiology, Peking University Third Hospital, Beijing 100191, China.
FAU - Chang, C
AU  - Chang C
FAU - Wang, X H
AU  - Wang XH
FAU - Wang, J
AU  - Wang J
FAU - Liang, Y
AU  - Liang Y
FAU - Zhu, Q
AU  - Zhu Q
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Transforming Growth Factor beta1)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - *Asthma
MH  - Eosinophils
MH  - Humans
MH  - Inflammation
MH  - Matrix Metalloproteinase 9
MH  - Respiratory Function Tests
MH  - Software
MH  - Sputum
MH  - *Tomography, X-Ray Computed
MH  - Transforming Growth Factor beta1
OTO - NOTNLM
OT  - Asthma
OT  - Bronchi
OT  - Cicatrix, hypertrophic
EDAT- 2018/07/24 06:00
MHDA- 2018/10/31 06:00
CRDT- 2018/07/23 06:00
PHST- 2018/07/23 06:00 [entrez]
PHST- 2018/07/24 06:00 [pubmed]
PHST- 2018/10/31 06:00 [medline]
AID - 10.3760/cma.j.issn.0376-2491.2018.27.012 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2018 Jul 17;98(27):2184-2188. doi: 
      10.3760/cma.j.issn.0376-2491.2018.27.012.