PMID- 30033478 OWN - NLM STAT- MEDLINE DCOM- 20200505 LR - 20200505 IS - 1573-7322 (Electronic) IS - 1382-4147 (Linking) VI - 24 IP - 1 DP - 2019 Jan TI - Diagnostic and prognostic role of cardiac magnetic resonance in acute myocarditis. PG - 81-90 LID - 10.1007/s10741-018-9724-x [doi] AB - Acute myocarditis (AM) is commonly found in everyday clinical practice. Differential diagnosis between various causes of myocardial damage with non-obstructive coronary arteries can be cumbersome for clinician. Moreover, AM may be provoked by a number of different causes and clinical presentation can be heterogeneous with potential overlap going from asymptomatic or subclinical to severe heart failure, arrhythmias, and death. Cardiac magnetic resonance (CMR) over the last decades has proven to be the diagnostic technique of choice since it allows identifying AM with excellent diagnostic accuracy. Latest technological advancement with parametric imaging such as T1 and T2 mapping further increases sensitivity and provides additional help towards a correct diagnosis. CMR however is no longer to be considered as a mere diagnostic tool but also as a powerful source of prognostic information. Scientific evidence has corroborated CMR's role beyond diagnosis demonstrating how late gadolinium enhancement (LGE) presence is a powerful predictor of cardiac events and how the presence of septal LGE is to be considered of worst prognosis regardless of LGE extension even in patients with preserved global systolic function. CMR should be routinely performed in all patients with AM suspicion since its diagnostic and prognostic role is of paramount important and could modify therapeutic strategy and subsequent clinical decisions. FAU - Grigoratos, Chrysanthos AU - Grigoratos C AD - Fondazione Gabriele Monasterio CNR/Regione Toscana, via Giuseppe Moruzzi, 1, 56124, Pisa, Italy. cgrigoratos@ftgm.it. AD - Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy. cgrigoratos@ftgm.it. FAU - Di Bella, Gianluca AU - Di Bella G AD - Clinical and Experimental Department of Medicine and Pharmacology, University of Messina, Messina, Italy. FAU - Aquaro, Giovanni Donato AU - Aquaro GD AD - Fondazione Gabriele Monasterio CNR/Regione Toscana, via Giuseppe Moruzzi, 1, 56124, Pisa, Italy. LA - eng PT - Journal Article PT - Review PL - United States TA - Heart Fail Rev JT - Heart failure reviews JID - 9612481 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Acute Disease MH - Clinical Decision-Making/methods MH - Contrast Media/metabolism MH - Data Accuracy MH - Diagnosis, Differential MH - Female MH - Gadolinium/metabolism MH - Humans MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Myocarditis/*diagnostic imaging MH - Prognosis MH - Septum of Brain/metabolism OTO - NOTNLM OT - Cardiac magnetic resonance OT - Late gadolinium enhancement OT - Myocardial fibrosis OT - Myocardial oedema OT - Myocarditis OT - Prognosis EDAT- 2018/07/24 06:00 MHDA- 2020/05/06 06:00 CRDT- 2018/07/24 06:00 PHST- 2018/07/24 06:00 [pubmed] PHST- 2020/05/06 06:00 [medline] PHST- 2018/07/24 06:00 [entrez] AID - 10.1007/s10741-018-9724-x [pii] AID - 10.1007/s10741-018-9724-x [doi] PST - ppublish SO - Heart Fail Rev. 2019 Jan;24(1):81-90. doi: 10.1007/s10741-018-9724-x.