PMID- 30033685
OWN - NLM
STAT- MEDLINE
DCOM- 20190902
LR  - 20230926
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 6
IP  - 14
DP  - 2018 Jul
TI  - Neurovascular coupling response to cognitive examination in healthy controls: a 
      multivariate analysis.
PG  - e13803
LID - 10.14814/phy2.13803 [doi]
LID - e13803
AB  - Cognitive testing with transcranial Doppler ultrasonography (TCD) has been used 
      to assess neurovascular coupling (NVC), but few studies address its multiple 
      contributions. Subcomponent analysis considers the relative myogenic (resistance 
      area product, RAP) and metabolic (critical closing pressure (CrCP)) contributors. 
      The aim of this study was to investigate the changes in subcomponents that occur 
      with cognitive stimulation with the Addenbrooke's Cognitive Examination (ACE-III) 
      in healthy controls. Healthy volunteers underwent continuous recording of 
      bilateral TCD, heart rate (HR, three-lead ECG), end-tidal CO(2) (ETCO(2) , 
      capnography), and mean arterial pressure (MAP, Finometer). The study comprised a 
      5-min baseline recording, followed by all 20 paradigms from the ACE-III. The 
      cerebral blood flow velocity (CBFv) response was decomposed into the relative 
      contributions (subcomponents); V(BP) (MAP), V(CrCP) (CrCP), and V(RAP) (RAP). 
      Data are presented as peak population normalized mean changes from baseline, and 
      median area under the curve (AUC). Forty bilateral datasets were obtained (27 
      female, 37 right hand dominant). V(BP) increased at task initiation in all 
      paradigms but differed between tasks (range (SD): 4.06 (8.92)-16.04 (12.23) %, 
      P < 0.05). HR, but not ETCO(2) , also differed significantly (P < 0.05). Changes 
      in V(RAP) reflected changes in MAP, but in some paradigms atypical responses were 
      seen. V(CrCP) AUC varied significantly within paradigm sections (range [SD]: 18.4 
      [24.17] to 244.21 [243.21] %*s, P < 0.05). All paradigms demonstrated changes in 
      subcomponents with cognitive stimulation, and can be ranked based on their 
      relative presumed metabolic demand. The integrity of NVC requires further 
      investigation in patient populations.
CI  - (c) 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on 
      behalf of The Physiological Society and the American Physiological Society.
FAU - Beishon, Lucy
AU  - Beishon L
AD  - Department of Cardiovascular Sciences, University of Leicester, Leicester, United 
      Kingdom.
FAU - Williams, Claire A L
AU  - Williams CAL
AD  - Department of Cardiovascular Sciences, University of Leicester, Leicester, United 
      Kingdom.
FAU - Robinson, Thompson G
AU  - Robinson TG
AD  - Department of Cardiovascular Sciences, University of Leicester, Leicester, United 
      Kingdom.
AD  - NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, 
      United Kingdom.
FAU - Haunton, Victoria J
AU  - Haunton VJ
AD  - Department of Cardiovascular Sciences, University of Leicester, Leicester, United 
      Kingdom.
AD  - NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, 
      United Kingdom.
FAU - Panerai, Ronney B
AU  - Panerai RB
AD  - Department of Cardiovascular Sciences, University of Leicester, Leicester, United 
      Kingdom.
AD  - NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, 
      United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
SB  - IM
MH  - Adult
MH  - Brain/blood supply/diagnostic imaging/*physiology
MH  - *Cerebrovascular Circulation
MH  - *Cognition
MH  - Female
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Multivariate Analysis
MH  - Neuropsychological Tests
MH  - Ultrasonography, Doppler, Transcranial
PMC - PMC6055030
OTO - NOTNLM
OT  - Addenbrooke's cognitive examination
OT  - cerebral blood flow
OT  - cognitive tasks
OT  - neurovascular coupling
OT  - transcranial doppler ultrasonography
EDAT- 2018/07/24 06:00
MHDA- 2019/09/03 06:00
PMCR- 2018/07/23
CRDT- 2018/07/24 06:00
PHST- 2018/04/24 00:00 [received]
PHST- 2018/06/24 00:00 [accepted]
PHST- 2018/07/24 06:00 [entrez]
PHST- 2018/07/24 06:00 [pubmed]
PHST- 2019/09/03 06:00 [medline]
PHST- 2018/07/23 00:00 [pmc-release]
AID - PHY213803 [pii]
AID - 10.14814/phy2.13803 [doi]
PST - ppublish
SO  - Physiol Rep. 2018 Jul;6(14):e13803. doi: 10.14814/phy2.13803.