PMID- 30034929
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2156-7514 (Print)
IS  - 2156-5597 (Electronic)
IS  - 2156-5597 (Linking)
VI  - 8
DP  - 2018
TI  - Normalized Subtraction of Serial Brain Magnetic Resonance Images and 
      Fludeoxyglucose-Positron Emission Tomography Images for Tumor Treatment 
      Monitoring: Case Report and Method Description.
PG  - 25
LID - 10.4103/jcis.JCIS_14_18 [doi]
LID - 25
AB  - A 60-year-old Caucasian male with a long history of cigarette smoking was 
      diagnosed with epidermal growth factor receptor-mutation negative lung 
      adenocarcinoma. The single cerebral metastasis in the right frontal lobe was 
      treated with stereotactic radiosurgery and systemic chemotherapies. Normalized 
      subtraction (NS) method was used to evaluate the serial brain magnetic resonance 
      (MR) and fludeoxyglucose-positron emission tomography (FDG-PET) findings 
      retrospectively, and the potential benefit of concurrent NS of serial MR images 
      (MRIs) and PET images was demonstrated. MIM 4.1 (MIM Software Inc., Cleveland, 
      OH) was used to co-register MRI with PET data and to perform NS on the serial MRI 
      and PET data. MIM 4.1 provides fully automated alignment of imaging data by 
      maximization of mutual information. Cortical regions distant from the brain 
      lesion were used to adjust for the intensity differences between scans, so the 
      voxel differences in normal brain regions were near zero in the NS images. A 
      difference of 15% or greater in voxel densities was used for both MRI and PET, 
      above or below which a change in MR signal intensity and FDG avidity was 
      considered significant. The use of NS, in this case, allowed for an enhanced 
      correlation of morphologic and functional information, which may have added value 
      in the early treatment monitoring of brain tumors and help distinguish recurrent 
      tumor from postradiation changes.
FAU - Nguyen, Nghi C
AU  - Nguyen NC
AD  - Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, 
      Pennsylvania.
FAU - Osman, Medhat M
AU  - Osman MM
AD  - Department of Radiology, Saint Louis University, Saint Louis, Missouri, United 
      States.
LA  - eng
PT  - Case Reports
DEP - 20180628
PL  - United States
TA  - J Clin Imaging Sci
JT  - Journal of clinical imaging science
JID - 101564708
PMC - PMC6034356
OTO - NOTNLM
OT  - Brain tumor
OT  - fludeoxyglucose positron emission tomography
OT  - magnetic resonance imaging
OT  - normalized subtraction
OT  - treatment monitoring
COIS- There are no conflicts of interest.
EDAT- 2018/07/24 06:00
MHDA- 2018/07/24 06:01
PMCR- 2018/06/28
CRDT- 2018/07/24 06:00
PHST- 2018/03/06 00:00 [received]
PHST- 2018/04/20 00:00 [accepted]
PHST- 2018/07/24 06:00 [entrez]
PHST- 2018/07/24 06:00 [pubmed]
PHST- 2018/07/24 06:01 [medline]
PHST- 2018/06/28 00:00 [pmc-release]
AID - JCIS-8-25 [pii]
AID - 10.4103/jcis.JCIS_14_18 [doi]
PST - epublish
SO  - J Clin Imaging Sci. 2018 Jun 28;8:25. doi: 10.4103/jcis.JCIS_14_18. eCollection 
      2018.