PMID- 30035005
OWN - NLM
STAT- MEDLINE
DCOM- 20190130
LR  - 20240330
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 19
DP  - 2018
TI  - Decoding moral emotions in obsessive-compulsive disorder.
PG  - 82-89
LID - S2213-1582(18)30110-4 [pii]
LID - 10.1016/j.nicl.2018.04.002 [doi]
AB  - BACKGROUND: Patients with obsessive-compulsive disorder (OCD) exhibit abnormal 
      neural responses when they experience particular emotions or when they evaluate 
      stimuli with emotional value. Whether these brain responses are sufficiently 
      distinctive to discriminate between OCD patients and healthy controls is unknown. 
      The present study is the first to investigate the discriminative power of 
      multivariate pattern analysis of regional fMRI responses to moral and non-moral 
      emotions. METHOD: To accomplish this goal, we performed a searchlight-based 
      multivariate pattern analysis to unveil brain regions that could discriminate 18 
      OCD patients from 18 matched healthy controls during provoked guilt, disgust, 
      compassion, and anger. We also investigated the existence of distinctive neural 
      patterns while combining those four emotions (herein termed multiemotion 
      analysis). RESULTS: We found that different frontostriatal regions discriminated 
      OCD patients from controls based on individual emotional experiences. Most 
      notably, the left nucleus accumbens (NAcc) discriminated OCD patients from 
      controls during both disgust and the multiemotion analysis. Among other regions, 
      the angular gyrus responses to anger and the lingual and the middle temporal gyri 
      in the multi-emotion analysis were highly discriminant between samples. 
      Additional BOLD analyses supported the directionality of these findings. 
      CONCLUSIONS: In line with previous studies, differential activity in regions 
      beyond the frontostriatal circuitry differentiates OCD from healthy volunteers. 
      The finding that the response of the left NAcc to different basic and moral 
      emotions is highly discriminative for a diagnosis of OCD confirms current 
      pathophysiological models and points to new venues of research.
FAU - Fontenelle, Leonardo F
AU  - Fontenelle LF
AD  - D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil; Brain & 
      Mental Health Laboratory, Monash Institute of Cognitive and Clinical 
      Neurosciences, Monash University, Victoria, Australia; Obsessive, Compulsive, and 
      Anxiety Spectrum Research Program, Institute of Psychiatry, Federal University of 
      Rio de Janeiro, Brazil. Electronic address: lfontenelle@gmail.com.
FAU - Frydman, Ilana
AU  - Frydman I
AD  - D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil; 
      Obsessive, Compulsive, and Anxiety Spectrum Research Program, Institute of 
      Psychiatry, Federal University of Rio de Janeiro, Brazil.
FAU - Hoefle, Sebastian
AU  - Hoefle S
AD  - D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
FAU - Oliveira-Souza, Ricardo
AU  - Oliveira-Souza R
AD  - D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
FAU - Vigne, Paula
AU  - Vigne P
AD  - D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil; 
      Obsessive, Compulsive, and Anxiety Spectrum Research Program, Institute of 
      Psychiatry, Federal University of Rio de Janeiro, Brazil.
FAU - Bortolini, Tiago S
AU  - Bortolini TS
AD  - D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
FAU - Suo, Chao
AU  - Suo C
AD  - Brain & Mental Health Laboratory, Monash Institute of Cognitive and Clinical 
      Neurosciences, Monash University, Victoria, Australia.
FAU - Yucel, Murat
AU  - Yucel M
AD  - Brain & Mental Health Laboratory, Monash Institute of Cognitive and Clinical 
      Neurosciences, Monash University, Victoria, Australia.
FAU - Mattos, Paulo
AU  - Mattos P
AD  - D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
FAU - Moll, Jorge
AU  - Moll J
AD  - D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180404
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Behavior/physiology
MH  - Brain/physiology/physiopathology
MH  - Emotions/*physiology
MH  - Empathy/physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - *Morals
MH  - Motivation/*physiology
MH  - Multivariate Analysis
MH  - Obsessive-Compulsive Disorder/*psychology
MH  - Young Adult
PMC - PMC6051311
OTO - NOTNLM
OT  - Moral emotion
OT  - Obsessive-compulsive disorder
OT  - Sentiment
OT  - fMRI
EDAT- 2018/07/24 06:00
MHDA- 2019/01/31 06:00
PMCR- 2018/04/04
CRDT- 2018/07/24 06:00
PHST- 2017/12/08 00:00 [received]
PHST- 2018/03/07 00:00 [revised]
PHST- 2018/04/01 00:00 [accepted]
PHST- 2018/07/24 06:00 [entrez]
PHST- 2018/07/24 06:00 [pubmed]
PHST- 2019/01/31 06:00 [medline]
PHST- 2018/04/04 00:00 [pmc-release]
AID - S2213-1582(18)30110-4 [pii]
AID - 10.1016/j.nicl.2018.04.002 [doi]
PST - epublish
SO  - Neuroimage Clin. 2018 Apr 4;19:82-89. doi: 10.1016/j.nicl.2018.04.002. 
      eCollection 2018.