PMID- 30035118
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20220318
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2018
DP  - 2018
TI  - Cardiac Magnetic Resonance in Stable Coronary Artery Disease: Added Prognostic 
      Value to Conventional Risk Profiling.
PG  - 2806148
LID - 10.1155/2018/2806148 [doi]
LID - 2806148
AB  - AIMS: Cardiovascular magnetic resonance (CMR) permits a comprehensive evaluation 
      of stable coronary artery disease (CAD). We sought to assess whether, in a large 
      contemporaneous population receiving optimal medical therapy, CMR independently 
      predicts prognosis beyond conventional cardiovascular risk factors (RF). METHODS: 
      We performed a single centre, observational prospective study that enrolled 465 
      CAD patients (80% males; 63+/-11 years), optimally treated with ACE-inhibitors/ARB, 
      aspirin, and statins (76-85%). Assessments included conventional evaluation 
      (clinical history, atherosclerosis RF, electrocardiography, and echocardiography) 
      and a comprehensive CMR with LV dimensions/function, late gadolinium enhancement 
      (LGE), and stress perfusion CMR (SPCMR). RESULTS: During a median follow-up of 62 
      months (IQR 23-74) there were 50 deaths and 92 major adverse cardiovascular 
      events (MACE). CMR variables improved multivariate model prediction power of 
      mortality and MACE over traditional RF alone (F-test p<0.05 and p<0.001, 
      respectively). LGE was an independent prognostic factor of mortality (hazard 
      ratio [95% CI]: 3.4 [1.3-8.8]); moreover, LGE (3.3 [1.7-6.3]) and SPCMR (2.1 
      [1.4-3.2]) were the best predictors of MACE. CONCLUSION: LGE is an independent 
      noninvasive marker of mortality in the long term in patients with stable CAD and 
      optimized medical therapy. Furthermore, LGE and SPCMR independently predict MACE 
      beyond conventional risk stratification.
FAU - Catalano, Oronzo
AU  - Catalano O
AUID- ORCID: 0000-0003-0826-6113
AD  - Division of Cardiology, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
FAU - Moro, Guido
AU  - Moro G
AD  - Division of Radiology, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
FAU - Mori, Alessia
AU  - Mori A
AD  - Occupational Medicine Unit, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
FAU - Perotti, Mariarosa
AU  - Perotti M
AD  - Division of Cardiology, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
FAU - Gualco, Alessandra
AU  - Gualco A
AD  - Division of Cardiology, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
FAU - Frascaroli, Mauro
AU  - Frascaroli M
AD  - Division of Radiology, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
FAU - Pesarin, Clara
AU  - Pesarin C
AD  - Division of Radiology, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
FAU - Napolitano, Carlo
AU  - Napolitano C
AD  - Molecular Cardiology, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
FAU - Ntusi, Ntobeko A B
AU  - Ntusi NAB
AD  - Department of Medicine, Cape Universities Body Imaging Centre, University of Cape 
      Town and Groote Schuur Hospital, Cape Town, South Africa.
FAU - Priori, Silvia G
AU  - Priori SG
AD  - Division of Cardiology, Molecular Cardiology, Istituti Clinici Scientifici 
      Maugeri, Pavia, Italy.
AD  - University of Pavia, Pavia, Italy.
LA  - eng
GR  - MC_PC_16096/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20180621
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aged
MH  - Contrast Media
MH  - Coronary Artery Disease/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
PMC - PMC6032669
EDAT- 2018/07/24 06:00
MHDA- 2019/01/15 06:00
PMCR- 2018/06/21
CRDT- 2018/07/24 06:00
PHST- 2018/02/16 00:00 [received]
PHST- 2018/05/22 00:00 [accepted]
PHST- 2018/07/24 06:00 [entrez]
PHST- 2018/07/24 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
PHST- 2018/06/21 00:00 [pmc-release]
AID - 10.1155/2018/2806148 [doi]
PST - epublish
SO  - Biomed Res Int. 2018 Jun 21;2018:2806148. doi: 10.1155/2018/2806148. eCollection 
      2018.