PMID- 30036109
OWN - NLM
STAT- MEDLINE
DCOM- 20190122
LR  - 20190122
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 21
IP  - 11
DP  - 2018 Nov
TI  - Anti-Helicobacter pylori Potential of Three Edible Plants Known as Quelites in 
      Mexico.
PG  - 1150-1157
LID - 10.1089/jmf.2017.0137 [doi]
AB  - "Quelites" are edible plants that are part of the traditional agro-ecosystems in 
      Mexico. These plants, despite their already known nutritional properties, are now 
      considered neglected and underutilized species. With the objective of promoting 
      their reinsertion in the markets and mainly, in daily diets, efforts have been 
      made to study them from multidisciplinary approaches to demonstrate their 
      beneficial properties. To generate evidence of an added health-promoting value 
      that would encourage quelites consumption, in the present work, the 
      anti-Helicobacter pylori activity of three representative quelite species, Anoda 
      cristata (Alache), Cnidoscolus aconitifolius (Chaya), and Crotalaria pumila 
      (Chepil), was tested. H. pylori is considered the etiological agent of gastritis, 
      ulcer, and gastric cancer, and represents a public health problem in Mexico and 
      worldwide. Aqueous (AQ) and dichloromethane-methanol (DM) extracts were obtained 
      from the three species of quelites to investigate their effect on H. pylori 
      growth and on two of its colonization factors (adherence and urease activity). DM 
      extracts from Chaya, Chepil, and Alache exert the best inhibitory effect on 
      bacterial growth, with minimum inhibitory concentrations of 62.5, 125, and 
      250 mug/mL, respectively. AQ and DM extracts inhibit bacterial adhesion by 30% to 
      50%. None of them has an effect on urease activity. The two flavonoids present in 
      A. cristata, acacetin and diosmetin, inhibit H. pylori growth by  approximately 90% with 
      3.9 mug/mL. These results provide new information about the anti-H. pylori 
      potential of three edible quelites, and give an added value, since their routine 
      consumption may impact on the prevention and/or control of H. pylori-associated 
      diseases.
FAU - Gomez-Chang, Erika
AU  - Gomez-Chang E
AD  - 1 Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autonoma 
      de Mexico , Ciudad Universitaria, Cd. Mx., Mexico.
FAU - Uribe-Estanislao, Guadalupe Vanessa
AU  - Uribe-Estanislao GV
AD  - 1 Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autonoma 
      de Mexico , Ciudad Universitaria, Cd. Mx., Mexico.
FAU - Martinez-Martinez, Maricruz
AU  - Martinez-Martinez M
AD  - 1 Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autonoma 
      de Mexico , Ciudad Universitaria, Cd. Mx., Mexico.
FAU - Galvez-Mariscal, Amanda
AU  - Galvez-Mariscal A
AD  - 2 Department of Food and Biotechnology, Faculty of Chemistry, Universidad 
      Nacional Autonoma de Mexico , Ciudad Universitaria, Cd. Mx., Mexico.
FAU - Romero, Irma
AU  - Romero I
AD  - 1 Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autonoma 
      de Mexico , Ciudad Universitaria, Cd. Mx., Mexico.
LA  - eng
PT  - Journal Article
DEP - 20180723
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Flavones)
RN  - 0 (Flavonoids)
RN  - 0 (Plant Extracts)
RN  - KWI7J0A2CC (acacetin)
RN  - TWZ37241OT (diosmetin)
SB  - IM
MH  - Anti-Bacterial Agents/chemistry/isolation & purification/*pharmacology
MH  - Crotalaria/*chemistry
MH  - Euphorbiaceae/*chemistry
MH  - Flavones/analysis/pharmacology
MH  - Flavonoids/pharmacology
MH  - Helicobacter Infections/*microbiology
MH  - Helicobacter pylori/*drug effects/growth & development
MH  - Humans
MH  - Malvaceae/*chemistry
MH  - Mexico
MH  - Microbial Sensitivity Tests
MH  - Plant Extracts/chemistry/isolation & purification/*pharmacology
MH  - Plants, Edible/chemistry
OTO - NOTNLM
OT  - Anoda cristata
OT  - Cnidoscolus aconitifolius
OT  - Crotalaria pumila
OT  - Helicobacter pylori
OT  - acacetin
OT  - antiadherent
OT  - antibacterial
OT  - diosmetin
OT  - urease
EDAT- 2018/07/24 06:00
MHDA- 2019/01/23 06:00
CRDT- 2018/07/24 06:00
PHST- 2018/07/24 06:00 [pubmed]
PHST- 2019/01/23 06:00 [medline]
PHST- 2018/07/24 06:00 [entrez]
AID - 10.1089/jmf.2017.0137 [doi]
PST - ppublish
SO  - J Med Food. 2018 Nov;21(11):1150-1157. doi: 10.1089/jmf.2017.0137. Epub 2018 Jul 
      23.