PMID- 30037343 OWN - NLM STAT- MEDLINE DCOM- 20190314 LR - 20240117 IS - 1532-429X (Electronic) IS - 1097-6647 (Print) IS - 1097-6647 (Linking) VI - 20 IP - 1 DP - 2018 Jul 23 TI - Relationship between CMR-derived parameters of ischemia/reperfusion injury and the timing of CMR after reperfused ST-segment elevation myocardial infarction. PG - 50 LID - 10.1186/s12968-018-0474-7 [doi] LID - 50 AB - BACKGROUND: To investigate the influence of cardiovascular magnetic resonance (CMR) timing after reperfusion on CMR-derived parameters of ischemia/reperfusion (I/R) injury in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: The study included 163 reperfused STEMI patients undergoing CMR during the index hospitalization. Patients were divided according to the time between revascularization and CMR (T(revasc-CMR): Tertile-1 93 h). T2-mapping derived area-at-risk (AAR) and intramyocardial-hemorrhage (IMH), and late gadolinium enhancement (LGE)-derived infarct size (IS) and microvascular obstruction (MVO) were quantified. T1-mapping was performed before and > 15 min after Gd-based contrast-agent administration yielding extracellular volume (ECV) of infarct. RESULTS: Main factors influencing I/R injury were homogenously balanced across T(revasc-CMR) tertiles. T2 values of infarct and remote regions increased with increasing T(revasc-CMR) tertiles (infarct: 60.0 +/- 4.9 vs 63.5 +/- 5.6 vs 64.8 +/- 7.5 ms; P < 0.001; remote: 44.3 +/- 2.8 vs 46.1 +/- 2.8 vs +/- 46.1 +/- 3.0; P = 0.001). However, T2 value of infarct largely and significantly exceeded that of remote myocardium in each tertile yielding comparable T2-mapping-derived AAR extent throughout T(revasc-CMR) tertiles (17 +/- 9% vs 19 +/- 9% vs 18 +/- 8% of LV, respectively, P = 0.385). Similarly, T2-mapping-based IMH detection and quantification were independent of T(revasc-CMR). LGE-derived IS and MVO were not influenced by T(revasc-CMR) (IS: 12 +/- 9% vs 12 +/- 9% vs 14 +/- 9% of LV, respectively, P = 0.646). In 68 patients without MVO, T1-mapping based ECV of infarct region was comparable across T(revasc-CMR) tertiles (P = 0.470). CONCLUSION: In STEMI patients, T2 values of infarct and remote myocardium increase with increasing CMR time after revascularization. However, these changes do not give rise to substantial variation of T2-mapping-derived AAR size nor of other CMR-based parameters of I/R. TRIAL REGISTRATION: ISRCTN03522116 . Registered 30.4.2018 (retrospectively registered). FAU - Masci, Pier-Giorgio AU - Masci PG AUID- ORCID: 0000-0001-5196-9530 AD - Centre of Cardiac Magnetic Resonance, University Hospital Lausanne-CHUV, Lausanne, Switzerland. pier-giorgio.masci@chuv.ch. AD - Cardiology Division, Heart & Vessels Department, Lausanne University Hospital-CHUV, BH-09-792 Rue de Bugnon 46, CH-1011, Lausanne, Vaud, Switzerland. pier-giorgio.masci@chuv.ch. FAU - Pavon, Anna Giulia AU - Pavon AG AD - Centre of Cardiac Magnetic Resonance, University Hospital Lausanne-CHUV, Lausanne, Switzerland. AD - Cardio-Thoracic-Vascular Department, San Raffaele's Scientific Institute, Milan, Italy. FAU - Muller, Olivier AU - Muller O AD - Cardiology Division, Heart & Vessels Department, Lausanne University Hospital-CHUV, BH-09-792 Rue de Bugnon 46, CH-1011, Lausanne, Vaud, Switzerland. FAU - Iglesias, Juan-Fernando AU - Iglesias JF AD - Cardiology Division, Heart & Vessels Department, Lausanne University Hospital-CHUV, BH-09-792 Rue de Bugnon 46, CH-1011, Lausanne, Vaud, Switzerland. FAU - Vincenti, Gabriella AU - Vincenti G AD - Centre of Cardiac Magnetic Resonance, University Hospital Lausanne-CHUV, Lausanne, Switzerland. AD - Cardiology Division, Heart & Vessels Department, Lausanne University Hospital-CHUV, BH-09-792 Rue de Bugnon 46, CH-1011, Lausanne, Vaud, Switzerland. FAU - Monney, Pierre AU - Monney P AD - Centre of Cardiac Magnetic Resonance, University Hospital Lausanne-CHUV, Lausanne, Switzerland. AD - Cardiology Division, Heart & Vessels Department, Lausanne University Hospital-CHUV, BH-09-792 Rue de Bugnon 46, CH-1011, Lausanne, Vaud, Switzerland. FAU - Harbaoui, Brahim AU - Harbaoui B AD - Cardiology Division, Heart & Vessels Department, Lausanne University Hospital-CHUV, BH-09-792 Rue de Bugnon 46, CH-1011, Lausanne, Vaud, Switzerland. FAU - Eeckhout, Eric AU - Eeckhout E AD - Cardiology Division, Heart & Vessels Department, Lausanne University Hospital-CHUV, BH-09-792 Rue de Bugnon 46, CH-1011, Lausanne, Vaud, Switzerland. FAU - Schwitter, Juerg AU - Schwitter J AD - Centre of Cardiac Magnetic Resonance, University Hospital Lausanne-CHUV, Lausanne, Switzerland. AD - Cardiology Division, Heart & Vessels Department, Lausanne University Hospital-CHUV, BH-09-792 Rue de Bugnon 46, CH-1011, Lausanne, Vaud, Switzerland. LA - eng SI - ISRCTN/ISRCTN03522116 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180723 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 1BJ477IO2L (gadobutrol) SB - IM MH - Adult MH - Aged MH - Contrast Media/administration & dosage MH - Edema, Cardiac/*diagnostic imaging/etiology/physiopathology MH - Female MH - Humans MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Myocardial Reperfusion/*adverse effects MH - Myocardial Reperfusion Injury/*diagnostic imaging/etiology/physiopathology MH - Organometallic Compounds/administration & dosage MH - Predictive Value of Tests MH - Registries MH - ST Elevation Myocardial Infarction/diagnostic imaging/physiopathology/*surgery MH - Time Factors MH - Treatment Outcome PMC - PMC6055335 OTO - NOTNLM OT - Cardiovascular magnetic resonance OT - Extracellular volume OT - Myocardial edema OT - Myocardial infarction OT - T1-mapping OT - T2-mapping COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Ethic Commission of the Canton Vaud - Switzerland (PB_2016-02583) approved the study and patients provided written consent form for study participation CONSENT FOR PUBLICATION: Not applicable COMPETING INTERESTS: 1. Juerg Schwitter received grants or speaker fees from Bayer Healthcare, Germany 2. Juan Fernando Iglesias received grants or speaker fees from Biotronik AG, Astra Zeneca AG, Terumo Corp The other authors declare that they do not have competing interests PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2018/07/25 06:00 MHDA- 2019/03/15 06:00 PMCR- 2018/07/23 CRDT- 2018/07/25 06:00 PHST- 2018/02/20 00:00 [received] PHST- 2018/06/26 00:00 [accepted] PHST- 2018/07/25 06:00 [entrez] PHST- 2018/07/25 06:00 [pubmed] PHST- 2019/03/15 06:00 [medline] PHST- 2018/07/23 00:00 [pmc-release] AID - S1097-6647(23)00587-2 [pii] AID - 474 [pii] AID - 10.1186/s12968-018-0474-7 [doi] PST - epublish SO - J Cardiovasc Magn Reson. 2018 Jul 23;20(1):50. doi: 10.1186/s12968-018-0474-7.