PMID- 3003785
OWN - NLM
STAT- MEDLINE
DCOM- 19860221
LR  - 20080229
IS  - 0485-8611 (Print)
IS  - 0485-8611 (Linking)
VI  - 8
DP  - 1985
TI  - Proton therapy in Japan.
PG  - S235-43
AB  - There are two facilities for clinical trials with protons in Japan: the National 
      Institute of Radiological Sciences (NIRS), Chiba, and the Particle Radiation 
      Medical Science Center (PARMS), University of Tsukuba. At the National Institute 
      of Radiological Sciences, patient treatment with the 70 MeV proton beam began in 
      November 1979, and 29 patients were treated through December 1984. Of 11 patients 
      who received protons only, 9 have had local control of the tumor. Two of the 9 
      patients, suffering from recurrent tumor after radical photon beam irradiation, 
      developed complications after proton treatment. In the patients treated with 
      photons or neutrons followed by proton boost, tumors were controlled in 12 of 18 
      patients (66.6%), and no complications were observed in this series. Malignant 
      melanoma could not be controlled with the proton beam. A spot-beam-scanning 
      system for protons has been effectively used in the clinical trials to minimize 
      the dose to the normal tissues and to concentrate the dose in the target volume. 
      At the Particle Radiation Medical Science Center, University of Tsukuba, 
      treatment with a vertical 250 MeV proton beam was begun in April 1983, and 22 
      patients were treated through February 1984. Local control of the tumor was 
      observed in 14 of 22 patients (63.6%), whereas there was no local control in the 
      treatment of glioblastoma multiforme. There have been no severe complications in 
      patients treated at PARMS. The results suggest that local control of tumors will 
      be better with proton beams than with photon beams, whereas additional modalities 
      are required to manage radioresistant tumors.
FAU - Tsunemoto, H
AU  - Tsunemoto H
FAU - Morita, S
AU  - Morita S
FAU - Ishikawa, T
AU  - Ishikawa T
FAU - Furukawa, S
AU  - Furukawa S
FAU - Kawachi, K
AU  - Kawachi K
FAU - Kanai, T
AU  - Kanai T
FAU - Ohara, H
AU  - Ohara H
FAU - Kitagawa, T
AU  - Kitagawa T
FAU - Inada, T
AU  - Inada T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Radiat Res Suppl
JT  - Radiation research. Supplement
JID - 0401246
RN  - 0 (Protons)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Clinical Trials as Topic
MH  - Female
MH  - Gamma Rays
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/mortality/*radiotherapy
MH  - *Protons
MH  - Radiodermatitis/etiology
MH  - Radiotherapy Dosage
MH  - Radiotherapy, High-Energy/adverse effects
MH  - Relative Biological Effectiveness
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
PST - ppublish
SO  - Radiat Res Suppl. 1985;8:S235-43.