PMID- 30038557
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230926
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 12
DP  - 2018
TI  - Decreased Connection Between Reward Systems and Paralimbic Cortex in Depressive 
      Patients.
PG  - 462
LID - 10.3389/fnins.2018.00462 [doi]
LID - 462
AB  - Despite decades of research on depression, the underlying pathophysiology of 
      depression remains incompletely understood. Emerging evidence from task-based 
      studies suggests that the abnormal reward-related processing contribute to the 
      development of depression. It is unclear about the function pattern of 
      reward-related circuit during resting state in depressive patients. In present 
      study, seed-based functional connectivity was used to evaluate the functional 
      pattern of reward-related circuit during resting state. Selected seeds were two 
      key nodes in reward processing, medial orbitofrontal cortex (mOFC) and nucleus 
      accumbens (NAcc). Fifty depressive patients and 57 healthy participants were 
      included in present study. Clinical severity of participants was assessed with 
      Hamilton depression scale and Hamilton anxiety scale. We found that compared with 
      healthy participants, depressive patients showed decreased connectivity of right 
      mOFC with left temporal pole (TP_L), right insula extending to superior temporal 
      gyrus (INS_R/STG) and increased connectivity of right mOFC with left precuneus. 
      Similarly, decreased connectivity of left mOFC with TP_L and increased 
      connectivity with cuneus were found in depressive patients. There is also 
      decreased connectivity of right NAcc with bilateral temporal pole, as well as 
      decreased connectivity of left NAcc with INS_R/STG. In addition, the functional 
      connectivity of right nucleus accumbens with right temporal pole (TP_R) was 
      negatively correlated with clinical severity. Our results emphasize the role of 
      communication deficits between reward systems and paralimbic cortex in the 
      pathophysiology of depression.
FAU - Bai, Tongjian
AU  - Bai T
AD  - Department of Neurology, The First Affiliated Hospital, Anhui Medical University, 
      Hefei, China.
FAU - Zu, Meidan
AU  - Zu M
AD  - Department of Neurology, The First Affiliated Hospital, Anhui Medical University, 
      Hefei, China.
FAU - Chen, Yang
AU  - Chen Y
AD  - Anhui Mental Health Center, Hefei, China.
FAU - Xie, Wen
AU  - Xie W
AD  - Anhui Mental Health Center, Hefei, China.
FAU - Cai, Chunlan
AU  - Cai C
AD  - Anhui Mental Health Center, Hefei, China.
FAU - Wei, Qiang
AU  - Wei Q
AD  - Department of Neurology, The First Affiliated Hospital, Anhui Medical University, 
      Hefei, China.
FAU - Ji, Gong-Jun
AU  - Ji GJ
AD  - Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, 
      China.
AD  - Department of Medical Psychology, The First Affiliated Hospital, Anhui Medical 
      University, Hefei, China.
FAU - Tian, Yanghua
AU  - Tian Y
AD  - Department of Neurology, The First Affiliated Hospital, Anhui Medical University, 
      Hefei, China.
AD  - Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, 
      China.
AD  - Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, 
      Hefei, China.
FAU - Wang, Kai
AU  - Wang K
AD  - Department of Neurology, The First Affiliated Hospital, Anhui Medical University, 
      Hefei, China.
AD  - Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, 
      China.
AD  - Department of Medical Psychology, The First Affiliated Hospital, Anhui Medical 
      University, Hefei, China.
AD  - Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, 
      Hefei, China.
LA  - eng
PT  - Journal Article
DEP - 20180709
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC6046444
OTO - NOTNLM
OT  - depression
OT  - nucleus accumbens
OT  - orbitofrontal cortex
OT  - reward system
OT  - temporal pole
EDAT- 2018/07/25 06:00
MHDA- 2018/07/25 06:01
PMCR- 2018/01/01
CRDT- 2018/07/25 06:00
PHST- 2018/05/15 00:00 [received]
PHST- 2018/06/18 00:00 [accepted]
PHST- 2018/07/25 06:00 [entrez]
PHST- 2018/07/25 06:00 [pubmed]
PHST- 2018/07/25 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2018.00462 [doi]
PST - epublish
SO  - Front Neurosci. 2018 Jul 9;12:462. doi: 10.3389/fnins.2018.00462. eCollection 
      2018.