PMID- 30039528
OWN - NLM
STAT- MEDLINE
DCOM- 20191216
LR  - 20200728
IS  - 1541-0420 (Electronic)
IS  - 0006-341X (Print)
IS  - 0006-341X (Linking)
VI  - 75
IP  - 1
DP  - 2019 Mar
TI  - Personalized schedules for surveillance of low-risk prostate cancer patients.
PG  - 153-162
LID - 10.1111/biom.12940 [doi]
AB  - Low-risk prostate cancer patients enrolled in active surveillance (AS) programs 
      commonly undergo biopsies on a frequent basis for examination of cancer 
      progression. AS programs employ a fixed schedule of biopsies for all patients. 
      Such fixed and frequent schedules may schedule unnecessary biopsies. Since 
      biopsies are burdensome, patients do not always comply with the schedule, which 
      increases the risk of delayed detection of cancer progression. Motivated by the 
      world's largest AS program, Prostate Cancer Research International Active 
      Surveillance (PRIAS), we present personalized schedules for biopsies to counter 
      these problems. Using joint models for time-to-event and longitudinal data, our 
      methods combine information from historical prostate-specific antigen levels and 
      repeat biopsy results of a patient, to schedule the next biopsy. We also present 
      methods to compare personalized schedules with existing biopsy schedules.
CI  - (c) 2018 The Authors. Biometrics published by Wiley Periodicals, Inc. on behalf of 
      International Biometric Society.
FAU - Tomer, Anirudh
AU  - Tomer A
AUID- ORCID: 0000-0002-6058-6715
AD  - Department of Biostatistics, Erasmus University Medical Center, The Netherlands.
FAU - Nieboer, Daan
AU  - Nieboer D
AD  - Department of Public Health, Erasmus University Medical Center, The Netherlands.
FAU - Roobol, Monique J
AU  - Roobol MJ
AD  - Department of Urology, Erasmus University Medical Center, The Netherlands.
FAU - Steyerberg, Ewout W
AU  - Steyerberg EW
AD  - Department of Public Health, Erasmus University Medical Center, The Netherlands.
AD  - Department of Medical Statistics and Bioinformatics, Leiden University Medical 
      Center, The Netherlands.
FAU - Rizopoulos, Dimitris
AU  - Rizopoulos D
AD  - Department of Biostatistics, Erasmus University Medical Center, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180723
PL  - England
TA  - Biometrics
JT  - Biometrics
JID - 0370625
SB  - IM
MH  - Algorithms
MH  - *Appointments and Schedules
MH  - Biopsy/*statistics & numerical data
MH  - Chronic Disease Indicators
MH  - Computer Simulation
MH  - Disease Progression
MH  - Humans
MH  - Male
MH  - Precision Medicine/*methods
MH  - Prostatic Neoplasms/*pathology
MH  - Risk Assessment
PMC - PMC7380003
OTO - NOTNLM
OT  - Active surveillance
OT  - Biopsy
OT  - Joint models
OT  - Personalized medicine
OT  - Prostate cancer
EDAT- 2018/07/25 06:00
MHDA- 2019/12/18 06:00
PMCR- 2020/07/24
CRDT- 2018/07/25 06:00
PHST- 2017/11/01 00:00 [received]
PHST- 2018/06/01 00:00 [revised]
PHST- 2018/06/01 00:00 [accepted]
PHST- 2018/07/25 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2018/07/25 06:00 [entrez]
PHST- 2020/07/24 00:00 [pmc-release]
AID - BIOM12940 [pii]
AID - 10.1111/biom.12940 [doi]
PST - ppublish
SO  - Biometrics. 2019 Mar;75(1):153-162. doi: 10.1111/biom.12940. Epub 2018 Jul 23.